Download a practical guide to assay development and high throughput screening in drug discovery critical reviews in combinatorial chemistry in pdf or read a practical guide to assay development and high throughput screening in drug discovery critical reviews in combinatorial chemistry in pdf online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get a practical guide to assay development and high throughput screening in drug discovery critical reviews in combinatorial chemistry in pdf book now. This site is like a library, Use search box in the widget to get ebook that you want.



A Practical Guide To Assay Development And High Throughput Screening In Drug Discovery

Author: Taosheng Chen
Publisher: CRC Press
ISBN: 9781420070514
Size: 18.71 MB
Format: PDF, Kindle
View: 4037
Download and Read
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations. The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics. Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.

Analytical Methods In Combinatorial Chemistry Second Edition

Author: Bing Yan
Publisher: CRC Press
ISBN: 1420003526
Size: 31.50 MB
Format: PDF, Docs
View: 142
Download and Read
Since the publication of the benchmark first edition of this book, chemical library and combinatorial chemistry methods have developed into mature technologies. There have also been significant shifts in emphasis in combinatorial synthesis. Reflecting the growth in the field and the heightened focus on select areas, Analytical Methods in Combinatorial Chemistry, Second Edition updates a classic text and captures the current state of these technologies. Written by leaders in the field, this second edition includes several enhancements. A chapter on high-throughput analytical methods and informatics reflects the demand for quality control of library members. A new chapter focuses on high-throughput purification methods. All chapters have been updated with new data. Topics discussed in this second edition include: Properties of solid-phase samples, analytical studies targeted to understand these properties, and resin swelling Fourier Transform Infrared techniques On-support mass spectrometry and nuclear magnetic resonance methods used in the reaction optimization stage Combinatorial library analysis using spectrophotometric, fluorometric, and other methods Quality control of combinatorial libraries High-throughput purification methods Future directions and analytical challenges The coming decade is sure to usher in a new wave of progress in this critical field. This volume provides not only an analysis of the recent developments in analytical methods, technologies and applications; it also provides a window on future possibilities.

Combinatorial Chemistry

Author: Stephen R. Wilson
Publisher: John Wiley & Sons
ISBN: 9780471126874
Size: 38.63 MB
Format: PDF, ePub
View: 1595
Download and Read
Explores a new approach to drug discovery, covers a selection of organic chemistry technologies now available, and explains how the new techniques allows chemical compounds to be synthesized much more quickly

Comprehensive Toxicology

Author:
Publisher: Newnes
ISBN: 0080468845
Size: 61.53 MB
Format: PDF, ePub, Docs
View: 4255
Download and Read
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version

Issues In Pharmacology Pharmacy Drug Research And Drug Innovation 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464963444
Size: 16.74 MB
Format: PDF, Kindle
View: 3185
Download and Read
Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Chemistry And General Chemical Research 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464963290
Size: 26.83 MB
Format: PDF, Docs
View: 376
Download and Read
Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemistry and General Chemical Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemistry and General Chemical Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.