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Adenosine Receptors In Health And Disease

Author: Constance N. Wilson
Publisher: Springer Science & Business Media
ISBN: 9783540896159
Size: 74.26 MB
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Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

Methylxanthines

Author: Bertil B. Fredholm
Publisher: Springer Science & Business Media
ISBN: 9783642134432
Size: 53.49 MB
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In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Pharmacology Of Purine And Pyrimidine Receptors

Author:
Publisher: Academic Press
ISBN: 0123855330
Size: 43.81 MB
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This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development

Adenosine Receptors In Neurology And Psychiatry

Author:
Publisher: Academic Press
ISBN: 0128013184
Size: 60.63 MB
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This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume concentrates on adenosine receptor science, providing insights useful for actual drug discovery/development in neurology and psychiatry areas. Expertise of contributors Subject including practical drug development from basic science, as translational research taste Structure of contents focusing on two CNS areas for diseases (neurology and psychiatry)