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Analysis Of Longitudinal Data

Author: Peter Diggle
Publisher: OUP Oxford
ISBN: 0191664332
Size: 60.57 MB
Format: PDF, Kindle
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The first edition of Analysis for Longitudinal Data has become a classic. Describing the statistical models and methods for the analysis of longitudinal data, it covers both the underlying statistical theory of each method, and its application to a range of examples from the agricultural and biomedical sciences. The main topics discussed are design issues, exploratory methods of analysis, linear models for continuous data, general linear models for discrete data, and models and methods for handling data and missing values. Under each heading, worked examples are presented in parallel with the methodological development, and sufficient detail is given to enable the reader to reproduce the author's results using the data-sets as an appendix. This second edition, published for the first time in paperback, provides a thorough and expanded revision of this important text. It includes two new chapters; the first discusses fully parametric models for discrete repeated measures data, and the second explores statistical models for time-dependent predictors.

Multivariate Time Series Analysis And Applications

Author: William W. S. Wei
Publisher: John Wiley & Sons
ISBN: 1119502942
Size: 71.62 MB
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An essential guide on high dimensional multivariate time series including all the latest topics from one of the leading experts in the field Following the highly successful and much lauded book, Time Series Analysis—Univariate and Multivariate Methods, this new work by William W.S. Wei focuses on high dimensional multivariate time series, and is illustrated with numerous high dimensional empirical time series. Beginning with the fundamentalconcepts and issues of multivariate time series analysis,this book covers many topics that are not found in general multivariate time series books. Some of these are repeated measurements, space-time series modelling, and dimension reduction. The book also looks at vector time series models, multivariate time series regression models, and principle component analysis of multivariate time series. Additionally, it provides readers with information on factor analysis of multivariate time series, multivariate GARCH models, and multivariate spectral analysis of time series. With the development of computers and the internet, we have increased potential for data exploration. In the next few years, dimension will become a more serious problem. Multivariate Time Series Analysis and its Applications provides some initial solutions, which may encourage the development of related software needed for the high dimensional multivariate time series analysis. Written by bestselling author and leading expert in the field Covers topics not yet explored in current multivariate books Features classroom tested material Written specifically for time series courses Multivariate Time Series Analysis and its Applications is designed for an advanced time series analysis course. It is a must-have for anyone studying time series analysis and is also relevant for students in economics, biostatistics, and engineering.

Unified Methods For Censored Longitudinal Data And Causality

Author: Mark J. van der Laan
Publisher: Springer Science & Business Media
ISBN: 0387217002
Size: 41.64 MB
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A fundamental statistical framework for the analysis of complex longitudinal data is provided in this book. It provides the first comprehensive description of optimal estimation techniques based on time-dependent data structures. The techniques go beyond standard statistical approaches and can be used to teach masters and Ph.D. students. The text is ideally suitable for researchers in statistics with a strong interest in the analysis of complex longitudinal data.

Clinical Trials

Author: Steven Piantadosi
Publisher: John Wiley & Sons
ISBN: 1118959213
Size: 73.17 MB
Format: PDF, Kindle
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Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.

Nonparametric Analysis Of Longitudinal Data In Factorial Experiments

Author: Edgar Brunner
Publisher: Wiley-Interscience
Size: 20.36 MB
Format: PDF, Kindle
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The authoritative reference on nonparametric methods for evaluating longitudinal data in factorial designs Broadening the range of techniques that can be used to evaluate longitudinal data, Nonparametric Analysis of Longitudinal Data in Factorial Experiments presents nonparametric methods of evaluation that supplement the generalized linear models approach. Emphasizing the practical application of these methods in statistical procedures, this book provides a unified approach for the analysis of factorial designs involving longitudinal data that is appropriate for metric data, count data, ordered categorical data, and dichotomous data. Topics covered include nonparametric models, effects and hypotheses in experimental design, estimators for relative effects, experiments for one and several groups of subjects, multifactorial experiments, dependent replications, and experiments with numerous time points. The basic mathematical principles for the methods introduced here are described in theory, consistent with the book's minimal math requirements. Simple approximations for small data sets are provided, as well as ample chapter exercises to test skills, an appendix that includes original data for the examples used throughout the book, and downloadable SAS-IML macros for implementing the more extensive calculations. All applications are designed to be useful in many fields. Generously supplemented with more than 110 graphs and tables, Nonparametric Analysis of Longitudinal Data in Factorial Experiments is an essential reference for statisticians and biometricians, researchers in clinical trials, psychological studies, and in the fields of forestry, agriculture, sociology, ecology, and biology, as well as graduate students in statistics and biostatistics.

Symbolic Computation For Statistical Inference

Author: David F. Andrews
Publisher: Oxford University Press on Demand
ISBN: 9780198507055
Size: 13.91 MB
Format: PDF, Docs
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The development of statistical computing has had a huge impact on the subject, freeing statisticians from the need to perform tedious calculations and allowing researchers to perform progressively more complex operations. This book gives a coherent presentation of the theory underlying the computations, and provides a framework where computer algorithms are used to do much of the calculation inherent in statistics. Beginning with an outline of algorithms to cover much of an undergraduate course in probability and statistics, it then goes on to discuss various common distributions, likelihood, bootstrap and sampling.