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Analyzing Chromosomes

Author: Barbara H Czepulkowski
Publisher: Taylor & Francis
ISBN: 9781859961889
Size: 12.75 MB
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Analyzing Chromosomes is the user friendly guide to cytogenetic techniques. Basic theory is explained and linked with suggestions for suitable protocols. Techniques are provided in an easy-to-follow, step-by-step format with hints and tips to guide the novice. The book focuses on data interpretation, looks at possible errors and artifacts and provides trouble-shooting advice. Coverage includes: culture of human cells for chromosomal analysis; staining and banding of chromosome slides; types of abnormalities observed in chromosomes; constitutional chromosome abnormalities; acquired chromosome abnormalities in malignancy; new complimentary techniques. Analyzing Chromosomes is essential reading for trainees in cytogenetics new to the techniques, as a reference for more experienced workers and for those who make use of their cytogenetics service currently without a complete knowledge of the technology or its limitations.

Human Molecular Genetics 3

Author: T. Strachan
Publisher: Garland Science
ISBN: 9780815341840
Size: 26.97 MB
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Professors Tom Strachan & Andrew Read awarded the Education Award 2007 of the ESHG for their outstanding contribution to the dispersal of knowledge of modern human molecular genetics among students and professionals. Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics has been thoroughly revised. * Part One (Chapters 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory. * Part Two (Chapters 8-12) discusses the various genome sequencing projects and the insights they provide into the organisation, expression, variation and evolution of our genome. * Part Three (Chapters 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer. * Part Four (Chapters 19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy. There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of 'Ethics Boxes' to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics. Features: * Integration of Human Genome Project data throughout the book * Two new chapters 'Cells and Development' (Chapter 3) and 'Beyond the Genome Project: Functional Genomics, Proteomics and Bioinformatics' (Chapter 19) * Completely rewritten and reorganised coverage of complex disease genetics * Increased emphasis on gene function and on applications of genetic knowledge, including ethical issues * More prominence given to novel approaches to treating disease, such as cell-based therapies, pharmacogenomics, and personalised medicine * Special topic boxes that include detailed coverage of ethical, legal and social issues, including eugenics, genetic testing and discrimination, germ-line gene therapy and genetic enhancement, and human cloning * Contains two indices: a general index and one that contains names of diseases and disorders Supplements: Art of HMG3 (CD-ROM) 0-8153-4183-0: £34.00

Human Molecular Genetics

Author: Tom Strachan
Publisher: Garland Science
ISBN: 1136844066
Size: 17.39 MB
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Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject. The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

Success In Academic Surgery Basic Science

Author: Melina R. Kibbe
Publisher: Springer Science & Business Media
ISBN: 1447147367
Size: 41.16 MB
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Academic surgeons play an essential role in advancing the field and improving the care of patients with surgical disease. As the Association for Academic Surgery (AAS) Fall Courses (www.aasurg.org) and international courses continue to evolve to address the rapidly expanding scope and complexity of academic surgery, there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Basic Science is a unique and portable handbook that focuses on the basic and translational research. It includes new educational materials that are necessary to address not only the rapid evolution and rise of novel research methodologies in basic science and translational research, but also the changing environment for academic surgeons. Success in Academic Surgery: Basic Science is a valuable text for medical students, surgical residents, junior faculty and others considering a career in surgical research.

Molecular Genetics Of Cancer

Author: John Cowell
Publisher: Garland Science
ISBN: 1135323836
Size: 51.23 MB
Format: PDF
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Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.

Molecular Microbial Ecology

Author: Mark Osborn
Publisher: Garland Science
ISBN: 0203503392
Size: 21.25 MB
Format: PDF, ePub
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Microoganisms are distributed across every ecosystem, and microbial transformations are fundamental to the operation of the biosphere. Microbial ecology is the study of this interaction between microorganisms and their environment, and arguably represents one of the most important areas of biological research. Yet for many years our study of microbial flora was severely limited: the primary method of culturing microorganisms on media allowed us to study only between 0.1 and 10% of the total microbial flora in any given environment. Molecular Microbial Ecology gives a comprehensive guide to the recent revolution in the study of microorganisms in the environment. Details are given on molecular methods for isolating some of the previously uncultured and numerically dominant microbial groups. PCR-based approaches to studying prokaryotic systematics are described, including ribosomal RNA analysis and stable isotope probing. Later chapters cover DNA hybridisation techniques (including fluorescent in situ hybridisation), as well as genomic and metagenomic approaches to microbial ecology. Gathering together some of the world’s leading experts, this book provides an invaluable introduction to the modern theory and molecular methods used in studying microbial ecology.

Handbook Of Nature Inspired And Innovative Computing

Author: Albert Y. Zomaya
Publisher: Springer Science & Business Media
ISBN: 9780387277059
Size: 68.28 MB
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As computing devices proliferate, demand increases for an understanding of emerging computing paradigms and models based on natural phenomena. Neural networks, evolution-based models, quantum computing, and DNA-based computing and simulations are all a necessary part of modern computing analysis and systems development. Vast literature exists on these new paradigms and their implications for a wide array of applications. This comprehensive handbook, the first of its kind to address the connection between nature-inspired and traditional computational paradigms, is a repository of case studies dealing with different problems in computing and solutions to these problems based on nature-inspired paradigms. The "Handbook of Nature-Inspired and Innovative Computing: Integrating Classical Models with Emerging Technologies" is an essential compilation of models, methods, and algorithms for researchers, professionals, and advanced-level students working in all areas of computer science, IT, biocomputing, and network engineering.

Gentechnologie F R Einsteiger

Author: Terence A. Brown
Publisher: Springer
ISBN: 9783827413024
Size: 19.67 MB
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T. A. Browns "Gentechnologie fA1/4r Einsteiger" hat sich in mehreren Auflagen international als StandardeinfA1/4hrung in die Genklonierung und DNA-Analyse etabliert. Das Grundlagenlehrbuch setzt nur wenig Kenntnisse in Molekularbiologie und Genetik voraus und erlAutert in klarer Sprache sowohl die fundamentalen Prinzipien der wichtigsten gentechnologischen Methoden als auch die immer breiter werdende Palette ihrer Anwendungen. Die groAe Bedeutung der Gentechnologie fA1/4r die Grundlagenforschung und fA1/4r neue Entwicklungen in Biotechnologie und Medizin wird klar herausgearbeitet. Aoeber 250 zweifarbige Illustrationen erleichtern das VerstAndnis des Stoffes und machen die Konzepte und Arbeitstechniken der Gentechnologen anschaulich. Die neue Auflage ist vollstAndig A1/4berarbeitet und enthAlt zwei neue Kapitel. Eines prAsentiert die Methoden, mit denen man ganze Genome sequenziert, und beschreibt, was man aus den gewonnenen Sequenzinformationen ablesen kann. Das zweite widmet sich den Anwendungen der Gentechnologie in der Gerichtsmedizin - ein spannendes und aufschlussreiches Beispiel des Einsatzpotenzials der DNA-Analyse. Der groAen Bedeutung der Polymerasekettenreaktion (PCR) entsprechend wird diese Technik jetzt in einem frA1/4hen Abschnitt des Buches behandelt und durchgehend stArker berA1/4cksichtigt.

Molecular Biology Of The Cell

Author: Bruce Alberts
Publisher: Garland Science
ISBN: 1317563751
Size: 63.65 MB
Format: PDF, Kindle
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Sex Determination In Plants

Author: CC Ainsworth
Publisher: Garland Science
ISBN: 0203345991
Size: 56.99 MB
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Indispensable for all plant biologists, this is a fascinating and thorough examination of those factors which affect the sex determination of plant species, describing all of the main classes of plant with unisexual flowers hermaphrodite, monoecious and