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Antibiofilm Agents

Author: Kendra P. Rumbaugh
Publisher: Springer Science & Business Media
ISBN: 3642538339
Size: 37.64 MB
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This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

New Look To Phytomedicine

Author: Mohd Sajjad Ahmad Khan
Publisher: Academic Press
ISBN: 0128146206
Size: 78.64 MB
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New Look to Phytomedicine: Advancements in Herbal Products as Novel Drug Leads is a compilation of in-depth information on the phytopharmaceuticals used in modern medicine for the cure and management of difficult-to-treat and challenging diseases. Readers will find cutting-edge knowledge on the use of plant products with scientific validation, along with updates on advanced herbal medicine in pharmacokinetics and drug delivery. This authoritative book is a comprehensive collection of research based, scientific validations of bioactivities of plant products, such as anti-infective, anti-diabetic, anti-cancer, immune-modulatory and metabolic disorders presented by experts from across the globe. Step-by-step information is presented on chemistry, bioactivity and the functional aspects of biologically active compounds. In addition, the pharmacognosy of plant products with mechanistic descriptions of their actions, including pathogenicity is updated with information on the use of nanotechnology and molecular tools in relation to herbal drug research. Compiles up-to-date information on the chemotherapeutics used in the treatment of infective and metabolic disorders Presents advancements in the discovery of new drugs from plants using molecular and nanotechnology tools Examines detailed information on the use of herbals agents in cancer, HIV and other ailments, including diabetes, malaria and neurological disorders

The Therapeutic Use Of N Acetyl Cysteine In Medicine

Author: Richard Frye
Publisher: Springer
ISBN: 9811053111
Size: 69.26 MB
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Focusing on the practical use of N-Acetyl-Cysteine in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its positive benefits. Content includes examinations of its apparent therapeutic effects in various psychiatric and neurologic disorders, as well as other diseases involving inflammation. Explorations of its ability to act as a prophylactic for the prevention of iatrogenic toxicity, to improve neurotransmitter systems and neurogenesis in the brain, improve mitochondrial and redox metabolism, and positively modulate the immune system are also provided. N-Acetyl-Cysteine is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. Promise has been suggested in autism, Alzheimer’s disease, addiction, bipolar disorder, depression, trichotillomania, obsessive-compulsive disorder, schizophrenia, neuropathy and epilepsy, and, coupled with a positive safety profile, the potential of N-Acetyl-Cysteine appears considerable.

Culture Negative Orthopedic Biofilm Infections

Author: Garth D. Ehrlich
Publisher: Springer Science & Business Media
ISBN: 3642295541
Size: 68.64 MB
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During the recent transition between acute diseases caused by swarms of single planktonic bacteria, and chronic infections caused by bacteria growing in slime-enclosed biofilms, a general clinical consensus has emerged that pathologies with bacterial etiologies are frequently culture negative. Because biofilm infections now affect 17 million Americans per year (killing approximately 450,000), the suggestion that these common and lethal infections regularly go unnoticed by the only FDA-approved method for their detection and characterization is a matter of urgent concern. Biologically, we would expect that planktonic bacterial cells would colonize any new surface, including the surface of an agar plate, while the specialized sessile cells of a biofilm community would have no such proclivity. In the study of biofilm diseases ranging from otitis media to prostatitis, it was found that direct microscopy and DNA- and RNA-based molecular methods regularly document the presence of living bacteria in tissues and samples that are culture negative. The editors selected orthopedic biofilm infections as the subject of this book because these infections occur against a background of microbiological sterility in which modern molecular methods would be expected to find bacterial DNA, RNA-based microscopic methods would be expected to locate bacterial cells, and cultures would be negative. Moreover, in Orthopedics we find an already biofilm-adapted surgical group in which current strategies are based on the meticulous removal of compromised tissues, antibiotic options as based on high biofilm-killing local doses, and there are practical bedside strategies for dealing with biofilm infections. So here is where the new paradigm of biofilm infection meets the equally new paradigm of the culture negativity of biofilms, and this volume presents a conceptual synthesis that may soon combine the most effective molecular methods for the detection and identification of bacteria with a surgical discipline that is ready to help patients.

Perioperative Medical Management For Total Joint Arthroplasty

Author: Andrea Baldini
Publisher: Springer
ISBN: 331907203X
Size: 70.74 MB
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This volume describes the most recent medical guidelines for perioperative management in arthroplasty with the aim of facilitating excellent control of bleeding/thrombosis, pain and infection. For each area – hemostasis control, pain control and infection control – hot topics of key practical importance are discussed and contrasting perspectives are presented on controversial issues, covering the views of different practitioners and specialties. Using the information contained in this book, the practitioner will be in an excellent position to meet the principal goals of perioperative medical management. The information provided will assist in the choice of a multimodal guideline that minimizes the complication rate regarding bleeding and thromboembolism while not interfering with the patient’s recovery. Similarly, effective means of pain control and an optimized pain control protocol are discussed with a view to shortening hospital stay and achieving functional milestones that meet the patient’s expectations. Finally, host, wound and environmental factors relevant to infection and its prevention are explained, with discussion of the best means of prophylaxis, treatment and imaging. Surgeons, anesthesiologists and all medical practitioners and staff involved in the field of total hip and knee arthroplasty will find this book to be of value in their daily clinical practice. It will assist in the provision of enhanced medical management that ensures quicker recovery of the patient with fewer complications.

Antimicrobial Coatings And Modifications On Medical Devices

Author: Zheng Zhang
Publisher: Springer
ISBN: 3319574949
Size: 73.11 MB
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Based on a fundamental understanding of the interaction between bacteria and materials, this timely volume emphasizes the latest research in the antimicrobial interfacial design and provides an invaluable blueprint for improving antimicrobial performance on devices and products. Antimicrobial Coatings and Modifications targets reduction of microbial accumulation on biomedical and industrial materials through changing interfacial characteristics. Applying a viable antimicrobial coating or modification to resist alarming threats is a highly demanding requirement for many medical and engineering applications. Many contemporary books in the area of antimicrobial solution focus on applying antimicrobial agents or materials that can kill bacteria. The volume pays more attention to eliminating bacterial contamination and biofilm formation through surface characteristics with minimized bacterial resistance and environmental impact.

Angewandte Bioinformatik

Author: Paul M. Selzer
Publisher: Springer-Verlag
ISBN: 3662541351
Size: 18.44 MB
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Für Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einführung in die tägliche Anwendung der vielfältigen bioinformatischen Werkzeuge und gibt einen ersten Überblick über das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch Übungsbeispiele mit Lösungen gewährleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausführliches Sachverzeichnis runden das Buch ab. Für die 2. Auflage wurde das Werk umfassend aktualisiert.

Can Bacterial Interference Prevent Infection

Author: Manfred Beleut
Publisher: GRIN Verlag
ISBN: 3638131270
Size: 32.54 MB
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Referat (Handout) aus dem Jahr 2002 im Fachbereich Biologie - Mikrobiologie, Molekularbiologie, Note: gut, Friedrich-Alexander-Universität Erlangen-Nürnberg (Mikrobiologie), Veranstaltung: Mikrobiologisches Praktikum, Sprache: Deutsch, Abstract: Einleitung Brockhaus Infektion: ...das Eindringen von lebenden Keimen (z.B. Bakterien) in den Körper, in dem sie sich vermehren und so zur Erkrankung, einem Infekt, führen können... Kampf zwischen Mikro- und Makroorgansimus! [...]