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Applied Biopharmaceutics Pharmacokinetics Seventh Edition

Author: Leon Shargel
Publisher: McGraw Hill Professional
ISBN: 0071829644
Size: 42.52 MB
Format: PDF, Mobi
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The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics—now fully updated. Explains how to detect clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Helps you critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Chapters have been revised to reflect the latest clinical perspectives on drug performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy The field’s leading text for more than three decades, Applied Biopharmaceutics & Pharmacokinetics gets you up to speed on the basics of the discipline like no other resource. Practical problems and clinical examples with discussions are integrated within each chapter to help you apply principles to patient care and drug consultation situations. In addition, outstanding pedagogy, including chapter objectives, chapter summaries, and FAQs, plus additional application questions, identify and focus on key concepts. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics shows you how to use raw data and formulate the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination. The book also helps you work with pharmacokinetic and biopharmaceutic parameters to design and evaluate dosage regimens of drugs. In the seventh edition of this must-have interactive learning tool, most of the chapters are updated to reflect our current understanding of complex issues associated with safe and efficacious drug therapy.

Applied Biopharmaceutics Pharmacokinetics Sixth Edition

Author: Leon Shargel
Publisher: McGraw Hill Professional
ISBN: 0071603948
Size: 22.49 MB
Format: PDF, ePub, Docs
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A comprehensive textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics The field’s leading text for more than three decades Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to: Understand the basic concepts in biopharmaceutics and pharmacokinetics. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

Applied Clinical Pharmacokinetics 3 E

Author: Larry Bauer
Publisher: McGraw Hill Professional
ISBN: 007179459X
Size: 51.16 MB
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The most current, hands-on book in the field, Applied Clinical Pharmacokinetics The perfect textbook for pharmacy students learning the clinical application of pharmacokinetics, which is the mathematical tools for modifying doages. Students like that each chapter includes sample problems throughout the chapter, with a ton of practice problems at the end. Answers for the practice problems are in the back, but not detailed like the sample problems) *Changes in the 3/e includes: *All chapters updated and revised, as needed, including critical new references *Antibiotic individualization and monitoring sections increases use of pharmacodynamic parameters (Cmax/MIC, AUC24/MIC, Time above MIC) in addition to pharmacokinetic parameters to adjust dosages *Anticonvulsants section includes 5 new agents (Fosphenytoin, Lamotrigine, Levetiracetam, Oxcarbazepine, Eslicarbazepine) *Immunosuppressants section includes 1 new agent (Sirolimus), About the Book Text focuses on the latest standardized techniques and approaches to patient-specific dosing and provides up-to-date information on more recently moniotored drugs. Features Clear, useful coverage of drug dosing and drug monitoring Clear and concise summary of pharmacokinetic and pharmacodynamic concepts Practical help with calculations and equations Focus on the latest standardized techniques and approaches to patient-specific dosing Up-to-date information on more recently monitored drugs Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and congestive heart failure All the information practitioners need on drug categories such as antibiotics, cardiovascular agents, anticonvulsants, and immunosuppressants Full coverage of drugs such as Aminoglycosides, Vancomycin, Digoxin, Phenytoin, Carbamazepine, Theophylline, Cyclosporine, Tacrolimus, and Lithium Student friendly approach to teaching pharmacokinetics--sample problems embedded into the text to allow for students to apply what they are learing. .

Ansel S Pharmaceutical Dosage Forms And Drug Delivery Systems

Author: Loyd Allen
Publisher: Lippincott Williams & Wilkins
ISBN: 1469871947
Size: 69.85 MB
Format: PDF
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Long established as a trusted core text for pharmaceutics courses, this gold standard book is the most comprehensive source on pharmaceutical dosage forms and drug delivery systems available today. Reflecting the CAPE, APhA, and NAPLEX® competencies, Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems covers physical pharmacy, pharmacy practice, pharmaceutics, compounding, and dosage forms, as well as the clinical application of the various dosing forms in patient care. This Tenth Edition has been fully updated to reflect new USP standards and features a dynamic new full color design, new coverage of prescription flavoring, and increased coverage of expiration dates.

Concepts In Clinical Pharmacokinetics

Author: William Spruill
Publisher: ASHP
ISBN: 1585283894
Size: 10.47 MB
Format: PDF, Docs
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Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpu Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpufConcepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin “cheat sheet” to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides. - See more at: http://store.ashp.org/Store/ProductListing/ProductDetails.aspx?productId=153117615#sthash.58RrToYW.dpuf

Basic Pharmacokinetics And Pharmacodynamics

Author: Sara E. Rosenbaum
Publisher: John Wiley & Sons
ISBN: 1119143160
Size: 78.19 MB
Format: PDF, Docs
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Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Pharmacokinetic And Pharmacodynamic Data Analysis Concepts And Applications Third Edition

Author: Johan Gabrielsson
Publisher: CRC Press
ISBN: 9789186274924
Size: 75.11 MB
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This is a revised and very expanded version of the previous second edition of the book. "Pharmacokinetic and Pharmacodynamic Data Analysis" provides an introduction into pharmacokinetic and pharmacodynamic concepts using simple illustrations and reasoning. It describes ways in which pharmacodynamic and pharmacodynamic theory may be used to give insight into modeling questions and how these questions can in turn lead to new knowledge. This book differentiates itself from other texts in this area in that it bridges the gap between relevant theory and the actual application of the theory to real life situations. The book is divided into two parts; the first introduces fundamental principles of PK and PD concepts, and principles of mathematical modeling, while the second provides case studies obtained from drug industry and academia. Topics included in the first part include a discussion of the statistical principles of model fitting, including how to assess the adequacy of the fit of a model, as well as strategies for selection of time points to be included in the design of a study. The first part also introduces basic pharmacokinetic and pharmacodynamic concepts, including an excellent discussion of effect compartment (link) models as well as indirect response models. The second part of the text includes over 70 modeling case studies. These include a discussion of the selection of the model, derivation of initial parameter estimates and interpretation of the corresponding output. Finally, the authors discuss a number of pharmacodynamic modeling situations including receptor binding models, synergy, and tolerance models (feedback and precursor models). This book will be of interest to researchers, to graduate students and advanced undergraduate students in the PK/PD area who wish to learn how to analyze biological data and build models and to become familiar with new areas of application. In addition, the text will be of interest to toxicologists interested in learning about determinants of exposure and performing toxicokinetic modeling. The inclusion of the numerous exercises and models makes it an excellent primary or adjutant text for traditional PK courses taught in pharmacy and medical schools. A diskette is included with the text that includes all of the exercises and solutions using WinNonlin.

Casebook In Clinical Pharmacokinetics And Drug Dosing

Author: Henry Cohen
Publisher: McGraw Hill Professional
ISBN: 0071832769
Size: 46.13 MB
Format: PDF, ePub, Mobi
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A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.

Handbook Of Basic Pharmacokinetics Including Clinical Applications

Author: Wolfgang A. Ritschel
Publisher: Amer Pharmacists Assn
ISBN: 9781582121260
Size: 62.55 MB
Format: PDF, ePub, Mobi
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First published in 1976, the Handbook of Basic Pharmacokinetics … including Clinical Applications, 7th edition remains a user-friendly consolidation of principles and techniques for practitioners, researchers, and students involved in the various applications of pharmacokinetics. The book is current, accurate, and presented in a manner that fosters clinical application. Ten of the previous edition’s 39 chapters have been substantially updated: “Absorption/Transport Mechanisms,” “Physicochemical Factors Altering Biological Performance of Drugs,” “Drug Biotransformation,” “Excretion and Clearance of Drugs,” “Pediatric Pharmacokinetics,” “First Dose Size in Man,” “Correlation of Clinical Response with Drug Disposition,” “Bioavailability and Bioequivalence,” “Extracorporeal Methods of Drug Removal,” and “Pharmacogenetics and Pharmacogenomics.” Pharmacokinetic data profiles on an additional 150 drugs have been added to the Appendix, which now provides accessible information on more than 790 drugs. Key Features: 39 chapters, 10 of which were substantially revised with new, relevant information and current reference citations More than 225 illustrations and tables Glossary Appendix comprises pharmacokinetic data on more than 790 drugs—more than 150 new to this edition—a highly useful resource for clinical practitioners