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Author: Elizabeth Kutter
Publisher: CRC Press
ISBN: 9780203491751
Size: 39.93 MB
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In response to the emergence of pathogenic bacteria that cannot be treated with current antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight multidrug-resistant bacteria. Bacteriophages: Biology and Applications provides unparalleled, comprehensive information on bacteriophages and their applications, such as phage therapy. It offers techniques, media, and methodology involved in isolating and working with therapeutic phages. Photographs, line drawings, and electron micrographs of phages are also included. With its broad approach, this book is a useful reference for microbiologists, hematologists, and infectious disease researchers.

The Bacteriophages

Author: Richard Calendar
Publisher: Oxford University Press on Demand
ISBN: 0195148509
Size: 12.52 MB
Format: PDF
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This book describes the fundamental biology and applications of the bacteriophages, viruses that infect bacteria. It provides a current guide to each major phage family, highlights interesting topics, and provides a description of the kinds of phages that are associated with the major classes of eubacteria and archaea.


Author: Clark Denton
Publisher: Nova Science Pub Incorporated
ISBN: 9781626185135
Size: 41.94 MB
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Bacteriophages are obligate parasites that require bacterial hosts to replicate. Phages initiate infections by first attaching to the surface of bacteria and injecting their genomes into host cells. Virulent phages then hijack the host's cellular machinery to direct the production of phage virons that burst from the cell leading to bacterial lysis. In this book, the authors discuss the biology, applications and role in health and disease of bacteriophages. Topics include the varied potential roles of bacteriophages in the production of food from animal sources; phage therapy, biocontrol and commercial microbiology; abortive infection as a killer bacteriophage resistance strategy; bacteriophages as biocontrol tools of pathogens in meat and dairy products; bacteriophages as probiotics and decontaminating agents for food products; use of bacteriophages as surrogate indicators of viruses in water; promoter sequences for bacteriophage RNA polymerases; the use of bacteriophages in bacterial food pathogen regulation; and the interaction between bacteriophage and its bacterial host receptor, LamB.

Bacteriophages Practical Applications For Nature S Biocontrol

Author: Sabah A.A. Jassim
Publisher: Springer
ISBN: 3319540513
Size: 78.39 MB
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Bacteriophages: Practical Applications for Nature's Biocontrol' presents the latest information on uses in healthcare settings as well as animal husbandry, management and care of farm animals by using enhanced phages to replace antibiotics for growth promotion in animal feed or to prevent, control and treat disease in animals. The book will provide an overview of the function of phages and what researchers need to know, from phage hunting to laboratory design, management, production and application using different tools and methods. These key aspects will be discussed through a series of dedicated chapters, with topics covering auditing, validation, data analysis, microbial identification, culture media, and contamination control, etc.

Phage Therapy

Author: Ryszard Miedzybrodzki Jan Borysowski
Publisher: Caister Academic Press
ISBN: 1908230746
Size: 41.56 MB
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The emergence of bacteria resistant to multiple antibiotics has become a serious threat to public health and is considered one of the greatest challenges for contemporary medicine. Phage therapy, the use of bacteriophages as anti-bacterial agents, may offer an alternative treatment for bacterial infections. Phages have many potential applications in human medicine as well as dentistry, veterinary science, agriculture and food protection.Written by internationally recognized experts from leading world centres involved in phage research and phage therapy, this book provides comprehensive coverage of the topic with a focus on current research and emerging applications. The book opens with chapters covering the general characteristics of bacteriophages and the basic concepts of phage therapy. Further topics include the pharmacology of phage therapy, bacterial resistance, non-bactericidal effects of phages, main applications of bacteriophages in clinical medicine, plant pathosystems, animal production, food protection, and biofilm control, as well as regulatory and intellectual property aspects of phage therapy. Although the book focuses on applications of virulent bacteriophages, it also discusses genetically-engineered phages, phages as delivery vehicles for other antimicrobials, as well as phage lysins. This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection.

Phage And The Origins Of Molecular Biology

Author: John Cairns
Publisher: CSHL Press
ISBN: 0879698004
Size: 11.73 MB
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First published in 1966 as a 60th birthday tribute to Max Delbrck, this influential work is republished as "The Centennial Edition." The book was hailed as "[introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle ("Journal of History of Biology").

Molecular Biology Of Bacteriophage

Author: Jim D. Karam
Publisher: Amer Society for Microbiology
Size: 26.85 MB
Format: PDF
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Molecular Biology of Bacteriophage T4 highlights the value of this biological system as a research and teaching tool. The book is a sequel to the 1983 edition and is organized into six major sections: DNA metabolism, regulation of gene expression, phage morphogenesis, structure and function of selected proteins, host-phage interactions, and experiments in T4 molecular genetics. This last section presents research protocols while the other sections provide major reviews covering all aspects of T4 molecular biology. Researchers and students alike will particularly benefit from the overview chapters that introduce each section and from clearly outlined laboratory procedures that emphasize concepts in microbial molecular genetics. Since T4 has played a central role in the development of molecular biology as an academic discipline, the themes and experiments presented in this book provide an excellent framework for designing graduate and undergraduate courses in prokaryotic genetics and biochemistry. The Appendixes include detailed information on the T4 genomic map and gene products as well as guidelines for accessing important DNA sequence and literature databases. A comprehensive bibliography (over 3,400 entries) provides the most thorough and up-to-date compilation of T4 literature available in print.


Author: Stephen Mc Grath
Publisher: Horizon Scientific Press
ISBN: 190445514X
Size: 76.28 MB
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Bacteriophages (viruses that infect bacteria) are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host - for example, converting a non-pathogenic strain into a pathogen - and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously, from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. While infection of bacteria used in the fermentation industry can be very problematic and result in financial losses, in other scenarios, phage infection of bacteria can be exploited for industrial and/or medical applications. Interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections. Written by eminent international researchers actively involved in the disparate areas of bacteriophage research, this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current, most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype, and much more. The book will be essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology, and pharmaceutical companies, as well as in the food industry.