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Author: Elizabeth Kutter
Publisher: CRC Press
ISBN: 9780203491751
Size: 34.26 MB
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In response to the emergence of pathogenic bacteria that cannot be treated with current antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight multidrug-resistant bacteria. Bacteriophages: Biology and Applications provides unparalleled, comprehensive information on bacteriophages and their applications, such as phage therapy. It offers techniques, media, and methodology involved in isolating and working with therapeutic phages. Photographs, line drawings, and electron micrographs of phages are also included. With its broad approach, this book is a useful reference for microbiologists, hematologists, and infectious disease researchers.

The Bacteriophages

Author: Richard Calendar
Publisher: Oxford University Press on Demand
ISBN: 0195148509
Size: 59.82 MB
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This book describes the fundamental biology and applications of the bacteriophages, viruses that infect bacteria. It provides a current guide to each major phage family, highlights interesting topics, and provides a description of the kinds of phages that are associated with the major classes of eubacteria and archaea.


Author: Clark Denton
Publisher: Nova Science Pub Incorporated
ISBN: 9781626185135
Size: 71.31 MB
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Bacteriophages are obligate parasites that require bacterial hosts to replicate. Phages initiate infections by first attaching to the surface of bacteria and injecting their genomes into host cells. Virulent phages then hijack the host's cellular machinery to direct the production of phage virons that burst from the cell leading to bacterial lysis. In this book, the authors discuss the biology, applications and role in health and disease of bacteriophages. Topics include the varied potential roles of bacteriophages in the production of food from animal sources; phage therapy, biocontrol and commercial microbiology; abortive infection as a killer bacteriophage resistance strategy; bacteriophages as biocontrol tools of pathogens in meat and dairy products; bacteriophages as probiotics and decontaminating agents for food products; use of bacteriophages as surrogate indicators of viruses in water; promoter sequences for bacteriophage RNA polymerases; the use of bacteriophages in bacterial food pathogen regulation; and the interaction between bacteriophage and its bacterial host receptor, LamB.

Phage And The Origins Of Molecular Biology

Author: John Cairns
Publisher: CSHL Press
ISBN: 0879698004
Size: 32.38 MB
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First published in 1966 as a 60th birthday tribute to Max Delbrck, this influential work is republished as "The Centennial Edition." The book was hailed as "[introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle ("Journal of History of Biology").

Molecular Biology Of Bacteriophage

Author: Jim D. Karam
Publisher: Amer Society for Microbiology
Size: 77.74 MB
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Molecular Biology of Bacteriophage T4 highlights the value of this biological system as a research and teaching tool. The book is a sequel to the 1983 edition and is organized into six major sections: DNA metabolism, regulation of gene expression, phage morphogenesis, structure and function of selected proteins, host-phage interactions, and experiments in T4 molecular genetics. This last section presents research protocols while the other sections provide major reviews covering all aspects of T4 molecular biology. Researchers and students alike will particularly benefit from the overview chapters that introduce each section and from clearly outlined laboratory procedures that emphasize concepts in microbial molecular genetics. Since T4 has played a central role in the development of molecular biology as an academic discipline, the themes and experiments presented in this book provide an excellent framework for designing graduate and undergraduate courses in prokaryotic genetics and biochemistry. The Appendixes include detailed information on the T4 genomic map and gene products as well as guidelines for accessing important DNA sequence and literature databases. A comprehensive bibliography (over 3,400 entries) provides the most thorough and up-to-date compilation of T4 literature available in print.


Author: Stephen Mc Grath
Publisher: Horizon Scientific Press
ISBN: 190445514X
Size: 25.89 MB
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Bacteriophages (viruses that infect bacteria) are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host - for example, converting a non-pathogenic strain into a pathogen - and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously, from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. While infection of bacteria used in the fermentation industry can be very problematic and result in financial losses, in other scenarios, phage infection of bacteria can be exploited for industrial and/or medical applications. Interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections. Written by eminent international researchers actively involved in the disparate areas of bacteriophage research, this book focuses on the current rapid developments in this exciting field. The book opens with an excellent chapter that provides a broad overview of the topics and also highlights the multifaceted nature of bacteriophage research. This is followed by a series of reviews that focus on the current, most cutting-edge topics including bioinformatics and genomics, phage in the environment, bacteriophage in medicine, transfer of phage DNA to the host, contribution to host phenotype, and much more. The book will be essential reading for all phage researchers and of interest to molecular biologists and microbiologists working on bacteria in academia, biotechnology, and pharmaceutical companies, as well as in the food industry.

Gram Positive Phages From Isolation To Application

Author: Jennifer Mahony
Publisher: Frontiers Media SA
ISBN: 2889194930
Size: 12.39 MB
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Phage biology is one of the most significant and fundamental aspects of biological research and is often used as a platform for model studies relating to more complex biological entities. For this reason, phage biology has enjoyed focused attention and significant advances have been made in the areas of phage genomics, transcriptomics and the development and characterisation of phage-resistance mechanisms. In recent years, considerable research has been performed to increase our understanding of the interactions of these phages with their hosts using genomic, biochemical and structural approaches. Such multidisciplinary approaches are core to developing a full understanding of the processes that govern phage infection, information that may be harnessed to develop anti-phage strategies that may be applied in food fermentations or applied in a positive sense in phage therapy applications. The co-evolutionary processes of these phages and their hosts have also been a considerable focus of research in recent years. Such data has promoted a deeper understanding of the means by which these phages attach to and infect their hosts and permitted the development of effective anti-phage strategies. Furthermore, the presence and activity of host-encoded phage-resistance systems that operate at various stages of the phage cycle and the potential for the application of such systems consolidates the value of research in this area. Conversely, phages and their components have been applied as therapeutic agents against a number of pathogens including, among others, Clostridium difficile, Lactococcus garviae, Mycobacterium spp., Listeria spp. and the possibilities and limitations of these systems will be explored in this topic. Additionally, phage therapeutic approaches have been applied to the prevention of development of food spoilage organisms in the brewing and beverage sectors and exhonorate the positive applications of phages in the industrial setting. This research topic is aimed to address the most current issues as well as the most recent advances in the research of phages infecting Gram-positive bacteria covering areas such as phages in food fermentations, their impact in industry, phage ecology, genomics, evolution, structural analysis, phage-host interactions and the application of phages and components thereof as therapeutic agents against human and animal pathogens.