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Beta Lactams

Author: Bimal K. Banik
Publisher: Springer
ISBN: 3319556215
Size: 18.55 MB
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This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.

The Chemistry Of Lactams

Author: M.I. Page
Publisher: Springer Science & Business Media
ISBN: 9401129282
Size: 17.45 MB
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It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)

Beta Lactams Advances In Research And Application 2013 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1481681273
Size: 16.65 MB
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beta-Lactams—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Carbapenems. The editors have built beta-Lactams—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Carbapenems in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of beta-Lactams—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pharmacotherapeutics For Advanced Practice

Author: Virginia Poole Arcangelo
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781757843
Size: 16.89 MB
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This advanced pharmacotherapeutics text for nurse practitioners and physician assistants offers guidelines on prescribing drugs for over 50 common diseases and disorders. The book is organized by disorder rather than drug class and includes algorithms and case studies that illustrate critical thinking aspects of prescribing, such as drug selection, lifespan considerations, therapeutic drug monitoring, adverse reactions, unexpected outcomes, and when to change therapy. This Second Edition has new chapters on oncologic disorders and complementary and alternative medicines. Improved case studies reflect more realistic practice issues in decision-making. Additional areas addressed include food-drug interactions, dietary considerations, and concerns regarding geriatric patients.

Lactams Unique Structures Of Distinction For Novel Molecules

Author: Bimal K. Banik
Publisher: Springer
ISBN: 3642331882
Size: 76.53 MB
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I. Ojima • E. S. Zuniga • J. D. Seitz: Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests.- I. Fernández • Miguel A. Sierra: β -Lactams from Fischer Carbene Complexes: Scope, Limitations, and Reaction Mechanism.- Bablee Mandal • Basudeb Basu: Synthesis of β-Lactams Through Alkyne–Nitrone Cycloadditions.- T. T. Tidwell: Preparation of Bis-β-Lactams by Ketene–Imine Cycloadditions.- Edward Turos: The Chemistry and Biology of N-Thiolated β-Lactams.- Indrani Banik • Bimal K. Banik: Synthesis of β-Lactams and Their Chemical Manipulations Via Microwave-Induced Reactions.

Synthesis Of Biotinylated And C4 N1 Substituted Beta Lactams

Author: Rostislav Kuskovsky
Publisher:
ISBN: 9781124624082
Size: 70.92 MB
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The spread of antibiotic resistance inexorably diminishes effective treatments available against bacterial infections. beta-lactam antibiotics inhibit bacterial cell wall synthesis, pathways unique to bacteria, and thus are generally safe and effective. Monocyclic beta-lactam antibiotics with aryl-thio moieties at C4 were shown to be effective against Moraxella catharralis (M. cat) and Mycobacterium tuberculosis (Mtb), bacteria traditionally resistant to beta-lactams. A set of monocylic beta-lactams with trifluoromethyl-substituted thiophenol moieties were synthesized and then carbamoylated. Their activity against M.cat. and Mtb. is reported. The mechanism and cellular target of these beta-lactams is currently unknown. To that end, we have developed a novel synthesis to tag a derivative of these monocyclic beta-lactams with Biotin (Vitamin H). The design, synthesis and evaluation of antimicrobial activity are described.

Lactams Advances In Research And Application 2013 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1481689274
Size: 75.90 MB
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Lactams—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Caprolactam. The editors have built Lactams—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Caprolactam in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lactams—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Molecular Biotechnology Of Fungal Beta Lactam Antibiotics And Related Peptide Synthetases

Author: Axel A. Brakhage
Publisher: Springer Science & Business Media
ISBN: 9783540220329
Size: 74.13 MB
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In this important addition to the Old Testament Library, renowned scholar Brevard Childs writes on the Old Testament's most important theological book. He furnishes a fresh translation from the Hebrew and discusses questions of text, philology, historical background, and literary architecture, and then proceeds with a critically informed, theological interpretation of the text. The Old Testament Library provides fresh and authoritative treatments of important aspects of Old Testament study through commentaries and general surveys. The contributors are scholars of international standing.

Synthesis Of Lactam Antibiotics

Author: Alle Bruggink
Publisher: Springer Science & Business Media
ISBN: 9401008507
Size: 25.38 MB
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Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.