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Bioreactors For Tissue Engineering

Author: Julian Chaudhuri
Publisher: Springer Science & Business Media
ISBN: 1402037414
Size: 34.52 MB
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For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Bioreactor Systems For Tissue Engineering

Author: Cornelia Kasper
Publisher: Springer Science & Business Media
ISBN: 3540693564
Size: 41.89 MB
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The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed.

Bioreactors In Tissue Engineering

Author: S. Partap
Publisher:
ISBN: 9789533070797
Size: 65.44 MB
Format: PDF
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Funding for the salaries of Sonia Partap and Niamh Plunkett was provided by Science Foundation Ireland (President of Ireland Young Researcher Award, 04/Yl1/B531) and the Irish Research Council for Science, Engineering and Technology (RS/2005/173) respectively.

Bioreactor Systems For Tissue Engineering Ii

Author: Cornelia Kasper
Publisher: Springer Science & Business Media
ISBN: 3642160506
Size: 23.15 MB
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Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; * Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; * Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; * Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; * Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; * Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; * Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; * Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; * Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geißler, C. Gittel, H. Jülke, W. Brehm; * Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; * Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi

Introduction To Tissue Engineering

Author: Ravi Birla
Publisher: John Wiley & Sons
ISBN: 1118629698
Size: 38.57 MB
Format: PDF, Kindle
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A comprehensive reference and teaching aid on tissueengineering—covering everything from the basics ofregenerative medicine to more advanced and forward thinking topicssuch as the artificial liver, bladder, and trachea Regenerative medicine/tissue engineering is the process ofreplacing or regenerating human cells, tissues, or organs torestore or establish normal function. It is an incrediblyprogressive field of medicine that may, in the near future, helpwith the shortage of life-saving organs available through donationfor transplantation. Introduction to Tissue Engineering: Applications andChallenges makes tissue engineering more accessible toundergraduate and graduate students alike. It provides a systematicand logical eight-step process for tissue fabrication. Specificchapters have been dedicated to provide in-depth principles formany of the supporting and enabling technologies during the tissuefabrication process and include biomaterial development andsynthesis, bioreactor design, and tissue vascularization. Thetissue fabrication process is further illustrated with specificexamples for liver, bladder, and trachea. Section-coverage includesan overall introduction of tissue engineering; enabling andsupporting technologies; clinical applications; and case studiesand future challenges. Introduction to Tissue Engineering: Presents medical applications of stem cells in tissueengineering Deals with the effects of chemical stimulation (growthfactors and hormones) Covers current disease pathologies and treatment options(pacemakers, prosthesis) Explains bioengineering, design and fabrication, andcritical challenges during tissue fabrication Offers PowerPoint slides for instructors Features case studies and a section on future directions andchallenges As pioneering individuals look ahead to the possibility ofgenerating entire organ systems, students may turn to this text fora comprehensive understanding and preparation for the future ofregenerative medicine.

Computational Modeling In Tissue Engineering

Author: Liesbet Geris
Publisher: Springer Science & Business Media
ISBN: 3642325637
Size: 80.54 MB
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One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

Bioreactor Based Bone Tissue Engineering Influence Of Wall Collision On Osteoblast Cultured On Polymeric Microcarrier Scaffolds In Rotating Bioreactors

Author: Xiaojun Yu
Publisher:
ISBN:
Size: 55.14 MB
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Rotating bioreactors have been used to overcome the limitations of passive nutrient diffusion in three-dimensional (3D) constructs for tissue engineering of bone. It is hypothesized that conventional scaffolds undergo repeated wall collisions in rotating bioreactors, which may disrupt bone tissue formation. In this study, we investigated the effects of wall collision on osteoblastic cells cultured on a microsphere based scaffold of varying densities in comparison to water. The conventional heavier than water (HTW; density> 1 g/cm3) scaffolds were fabricated by sintering HTW microspheres of 85:15 poly (lactide-co-glycolide) (PLAGA), and mixed scaffolds were designed by mixing lighter than water (LTW;density

Tissue Engineering For Artificial Organs

Author: Anwarul Hasan
Publisher: John Wiley & Sons
ISBN: 3527338632
Size: 32.74 MB
Format: PDF
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A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

Multiscale Mechanobiology In Tissue Engineering

Author: Damien Lacroix
Publisher: Springer
ISBN: 9811080755
Size: 35.97 MB
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This book focuses on the mechanobiological principles in tissue engineering with a particular emphasis on the multiscale aspects of the translation of mechanical forces from bioreactors down to the cellular level. The book contributes to a better understanding of the design and use of bioreactors for tissue engineering and the use of mechanical loading to optimize in vitro cell culture conditions. It covers experimental and computational approaches and the combination of both to show the benefits that computational modelling can bring to experimentalists when studying in vitro cell culture within a scaffold. With topics from multidisciplinary fields of the life sciences, medicine, and engineering, this work provides a novel approach to the use of engineering tools for the optimization of biological processes and its application to regenerative medicine. The volume is a valuable resource for researchers and graduate students studying mechanobiology and tissue engineering. For undergraduate students it also provides deep insight into tissue engineering and its use in the design of bioreactors. The book is supplemented with extensive references for all chapters to help the reader to progress through the study of each topic.