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Bone Cancer

Author: Dominique Heymann
Publisher: Elsevier
ISBN: 0124167284
Size: 51.15 MB
Format: PDF
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Bone Cancer, Second Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases – from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays

Bone Cancer

Author: Dominique Heymann
Publisher: Academic Press
ISBN: 9780080953885
Size: 12.57 MB
Format: PDF, ePub, Docs
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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Imaging Of Bone Tumors And Tumor Like Lesions

Author: A. Mark Davies
Publisher: Springer Science & Business Media
ISBN: 3540779841
Size: 29.39 MB
Format: PDF
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Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.

Bone Tumors

Author: Jim S. Wu
Publisher: Springer Science & Business Media
ISBN: 1441908080
Size: 16.30 MB
Format: PDF, ePub
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Bone Tumors: A Practical Guide to Imaging is a concise guide to common tumors encountered by physicians in daily practice. The authors make use of high-yield facts, differential diagnoses, and extensive radiological images to introduce a wide range of bone tumors, focusing on their classic appearance and location in order to provide readers with a solid foundation of knowledge for tumor recognition and evaluation. The book includes explanations of methods for properly evaluating bone lesions, common imaging modalities used for diagnosis, and individual chapters covering different classes of benign and malignant tumors, including cartilage, osseous, fibrous, miscellaneous, and bone metastases. The book concludes with a comprehensive selection of 75 unknown cases, including brief clinical history, description of imaging findings, best differential diagnoses, and short discussion revealing the most likely diagnosis. Bone Tumors is an ideal resource for practicing physicians and residents in radiology, orthopedic surgery, pathology, and primary care. About the Authors Jim S. Wu, MD, is Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School. Mary G. Hochman, MD, is Chief of the Section of Musculoskeletal Imaging and Assistant Professor of Radiology at Beth Israel Deaconess Medical Center, Harvard Medical School.

Fna Cytology Of Soft Tissue And Bone Tumors

Author: H.A. Domanski
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318060771
Size: 75.74 MB
Format: PDF
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Fine-needle aspiration cytology (FNAC) has been commonly used to follow up on previously treated sarcomas or to confirm soft tissue and bone metastases of carcinomas, melanomas or lymphomas. Its role as the first-line approach in the diagnosis of primary soft tissue and bone tumors has increased due to progress of less invasive diagnostic procedures and the growing availability of diagnostic ancillary tests. This comprehensive and richly-illustrated volume presents cytomorphology of all common neoplastic soft tissue and bone lesions but also of rare tumors largely described in case reports. Key points for cytological features, differential diagnosis, and the use of ancillary tests are discussed and illustrated in order to facilitate the diagnostic work-up in FNA samples. The volume is organized on the basis of the most recent WHO classification used in surgical pathology in order to provide a practical guide for modern cytologic diagnosis of surgical soft tissue and bone pathology. It is aimed mainly at surgical pathologists and cytopathologists, but also at orthopedic surgeons and clinical oncologists.

Dorfman And Czerniak S Bone Tumors E Book

Author: Bogdan Czerniak
Publisher: Elsevier Health Sciences
ISBN: 0323091598
Size: 15.92 MB
Format: PDF, Docs
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The second edition of Dorfman and Czerniak's Bone Tumors brings together the latest data available on bone tumor pathology, making it the most comprehensive and encyclopedic reference on the epidemiology, clinical, pathologic, and molecular aspects of bone tumors. Now offered in full color and featuring updated imaging throughout, this one-of-a-kind resource provides a highly visual review of every disorder — from the common to the rare. Features comprehensive coverage of bone tumor pathology based on pathologic and clinical data on 11,500 benign and malignant bone tumors from patients treated at the MD Anderson Cancer Center. High-quality full-color images located throughout the text. Completely up-to-date molecular and genetic information is based on the most current genomic databases. Four brand-new chapters cover Radiographic Imaging of Bone Tumors; Hematopoetic Tumors; Neural Tumors; and Metastic Tumors of Bone. Includes information on molecular and genetic aspects of bone tumors from the UCSC Genome Browser, the Catologue of Somatic Mutations in Cancer, and the GeneCards Database of human genes. Features comprehensive data from nearly 30,000 benign and malignant primary bone tumors and tumor-like lesions from different sources, including over 8,400 malignant bone tumors from the National Cancer Institute’s Surveillance, Epidemiology and End Result project. Provides an enhanced visual understanding with updated radiographic imaging and new full-color, high-quality photomicrographs. Updated Molecular and Epidemiologic diagrams added to all new chapters.

Diagnostic Pathology Bone

Author: G. Petur Nielsen
Publisher: Elsevier Health Sciences
ISBN: 0323509274
Size: 54.59 MB
Format: PDF, ePub, Mobi
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Diagnostic Pathology: Bone was designed for practicing pathologists who need access to up-to-date, comprehensive, and concise bone pathology knowledge in one convenient place. It includes the latest diagnostic information in this challenging subspecialty, while its unique image collection serves as an exceptional educational aid. Authored and updated by experts in the field, Diagnostic Pathology: Bone will be an essential guide to understanding bone tumor pathology and diagnosis. Features quick-reference test data tables and diagnoses of various bone and cartilage tumor types Templated page layout, bulleted text, and a generous number of high-quality images for point-of-care clinical reference Stunning image collection includes gross pathology, histopathology, immunohistochemistry, FISH, and correlative radiologic imaging to serve as an exceptional educational aid Brand-new chapters covering Ewing-like sarcomas with specific translocations, other types of vascular tumors of bone (new entities), and tumors of the synovium Includes new molecular pathology diagnostic information for bone tumors and new immunohistochemical antigens to identify bone pathologies

Introduction To Cancer Metastasis

Author: Aamir Ahmad
Publisher: Academic Press
ISBN: 0128040335
Size: 32.27 MB
Format: PDF, ePub, Mobi
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Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe