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Advances In Cancer Stem Cell Biology

Author: Roberto Scatena
Publisher: Springer Science & Business Media
ISBN: 9781461408093
Size: 34.24 MB
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In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Neurodynamics An Exploration In Mesoscopic Brain Dynamics

Author: Walter Freeman
Publisher: Springer Science & Business Media
ISBN: 1447103718
Size: 39.68 MB
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Cortical evoked potentials are of interest primarily as tests of changing neuronal excitabilities accompanying normal brain function. The first three steps in the anal ysis of these complex waveforms are proper placement of electrodes for recording, the proper choice of electrical or sensory stimulus parameters, and the establish ment of behavioral control. The fourth is development of techniques for reliable measurement. Measurement consists of comparison of an unknown entity with a set of standard scales or dimensions having numerical attributes in preassigned degree. A physical object can be described by the dimensions of size, mass, density, etc. In addition there are dimensions such as location, velocity, weight, hardness, etc. Some of these dimensions can be complex (e. g. size depends on three or more subsidiary coordi nates), and some can be interdependent or nonorthogonal (e. g. specification of size and mass may determine density). In each dimension the unit is defined with refer ence to a standard physical entity, e. g. a unit of mass or length, and the result of measurement is expressed as an equivalence between the unknown and the sum of a specified number of units of that entity. The dimensions of a complex waveform are elementary waveforms from which that waveform can be built by simple addition. Any finite single-valued function of time is admissible. They are called basis functions (lO, 15), and they can be expressed in numeric as well as geometric form.

The Sucker S Kiss

Author: Alan Parker
Publisher: Macmillan
ISBN: 1466862866
Size: 19.33 MB
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During the San Francisco earthquake of 1906, seven-year-old Thomas Moran finds himself accidentally embarking on a career in pickpocketing. In the following years he becomes a master of his dubious craft and grows to manhood traveling from state to state across America. His picaresque journey takes him through Prohibition and the Depression; into the desperate highs of the Hootchy-Kootchy and the dying vineyards of California, accompanied by an array of richly drawn characters frantically clutching at the crumbling American dream. Italian and Chinese gangsters, con artists, corrupt clergy, and speakeasy bootleggers all have a part to play in Tommy's destiny, but it is Effie, the great love of his life, who offers him the chance to change his future, and tries to save him from himself. Colorfully written, engaging, and richly evocative of an extraordinary period in American history, The Sucker's Kiss marks the literary debut of master storyteller Alan Parker.

Contract With An Angel

Author: Andrew M. Greeley
Publisher: Macmillan
ISBN: 9781429997027
Size: 53.34 MB
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Millionaire media mogul Raymond Neenan can't believe his ears--or his eyes. the seat next to him, empty for the whole flight, now barely contains a huge man who looks a lot like Chicago Bulls superstar Michael Jordan. In fact, the "man" is the Archangel Michael ("Not Mike, not Mikey, but Michael. you got a problem with that?), and he's looking to make a deal for Neenan's immortal soul. Neenan isn't interested in his soul or anyone else's unless there is money in it, but a little well-timed turbulence that sends the plane hurtling earthward caused him to reconsider. If he doesn't believe in it, what could it hurt to sign? But for a man like Neenan,making amends is no easy task. Though he never knew it, he's damaged a lot of lives, including his own. He's hated or feared by his parents, his ex-wife, his children, and practically everyone he's ever met. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

Regulating Dispute Resolution

Author: Felix Steffek
Publisher: Bloomsbury Publishing
ISBN: 1782253572
Size: 50.25 MB
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This book proposes a principled approach to the regulation of dispute resolution. It covers dispute resolution mechanisms in all their varieties, including negotiation, mediation, conciliation, expert opinion, mini-trial, ombud procedures, arbitration and court adjudication. The authors present a transnational Guide for Regulating Dispute Resolution (GRDR). The regulatory principles contained in this Guide are based on a functional taxonomy of dispute resolution mechanisms, an open normative framework and a modular structure of regulatory topics. The Guide for Regulating Dispute Resolution is formulated and commented upon in a concise manner to assist legislators, policy-makers, professional associations, practitioners and academics in thinking about which solutions best suit local and regional circumstances. The aim of this book is to contribute to the understanding and development of the legal framework governing national and international dispute resolution. Theory, empirical research and regulatory models have been taken from the wealth of experience in 12 jurisdictions: Austria, Belgium, Denmark, England and Wales, France, Germany, Italy, Japan, the Netherlands, Norway, Switzerland and the United States of America. Experts with a background in academia, practice and law-making describe and analyse the regulatory framework and social reality of dispute resolution in these countries. On this basis the authors draw conclusions about policy choices, regulatory strategies and the practice of conflict resolution.

Enabling Innovation

Author: Jeschke Sabina
Publisher: Springer Science & Business Media
ISBN: 364224503X
Size: 38.87 MB
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The capability to innovate in an on-going manner is emerging as a decisive key factor in today's world of business and work. The ability to stay competitive is becoming identical with the ability to innovate. This book originated from the research and development project “International Monitoring” and outlines the topic of innovative capability from a practice-oriented angle. Contributions of German and international experts offer an enlightening glimpse behind the scenes of innovations. The central issue is not the description of features of successful innovation processes or how innovations can be efficiently controlled and managed, but under which conditions they can emerge in the first place. In what way can individuals, organizations, networks and societies be enabled to continuously induce innovations?

Friedrich List 1789 1846

Author: Eugen Wendler
Publisher: Springer-Verlag
ISBN: 3658026448
Size: 11.94 MB
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​In dieser ebenso unterhaltsamen wie informativen Biografie wird die Wirkungs- und Rezeptionsgeschichte der Theorien von Friedrich List auf der Basis seines außergewöhnlichen Lebenslaufes dargestellt. Der renommierte und mehrfach für seine Forschung ausgezeichnete List-Experte Eugen Wendler fasst hier die Ergebnisse seiner langjährigen Forschungsarbeit zusammen und ergänzt sie durch neueste Erkenntnisse und Quellen. So ist ein umfassendes und werthaltiges Werk entstanden, das zudem zahlreiche bislang noch unbekannte Abbildungen enthält.