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Cancer Stem Cells

Author: Huiping Liu
Publisher: Elsevier
ISBN: 0128039345
Size: 24.95 MB
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Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cells Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells Deepens a reader’s technical expertise in cancer stem cell biology

Pharmacology And Therapeutics For Dentistry

Author: Frank J. Dowd
Publisher: Elsevier Health Sciences
ISBN: 0323445950
Size: 25.29 MB
Format: PDF, Docs
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Gain a complete understanding of drugs affecting patient care! Pharmacology and Therapeutics for Dentistry, 7th Edition describes how to evaluate a patient’s health and optimize dental treatment by factoring in the drugs they take. It explores the basic principles of pharmacology, the ways that drugs affect the body, and the potential for adverse drug interactions. Developed by Frank Dowd, Barton Johnson, and Angelo Mariotti, with chapters from a team of expert contributors, this is the only book written by dental pharmacologists for the dental market. Whether you’re concerned about the drugs a patient is already taking or the drugs you prescribe for treatment, this book helps you reduce risk and provide effective dental care. Concise, comprehensive coverage helps you provide safe and effective dental care, exploring the fundamentals of pharmacology and clearly explaining actions of specific drug groups on systems in the human body in addition to covering special topics such as pain control, fear and anxiety, and oral complications of cancer therapy. An emphasis on the dental applications of pharmacology shows how to evaluate a patient’s health and optimize dental treatment by factoring in any medications the patient may be taking. Practical appendices provide easy access to essential information, summarizing topics such as drug interactions in clinical dentistry, antiseptics and disinfectants, herbs, controlled substances, protein biopharmaceuticals, drugs used to treat glaucoma, and abbreviations. Clinical Rationale for and Significance of Prescription Writing chapter and two appendices on drug prescribing cover both the medications that a patient may already be taking and drugs that a dentist may prescribe for treatment. Nearly 50 expert contributors represent a diverse, authoritative panel of authors from many of the major dental schools. NEW! Reorganized content is more concise, more relevant, and more visual, with a stronger focus on what you need to know for clinical practice. NEW! Case studies at the beginning of chapters and case discussions at the end help you connect pharmacologic concepts and principles with clinical practice. NEW summary tables and boxes provide quick reference to vital information, and include all-new tables on drug indications and mechanisms. NEW! Full-color design and illustrations are added to this edition, enhancing realism and visual learning. NEW companion website provides references linked to PubMed. NEW! Bullet points list key information at the beginning of each chapter, highlighting need-to-know concepts.

The Food Revolution

Author: John Robbins
Publisher: Conari Press
ISBN: 9781609252922
Size: 28.61 MB
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In 1987, John Robbins published Diet for a New America, which was an early version of this book, and he started the food revolution. He continues to work tirelessly to promote conscious food choices more than 20 years later. First published in 2001, The Food Revolution is still one of the most frequently cited and talked about books of the food-politics revolution. It was one of the very first books to discuss the negative health effects of eating genetically modified foods and animal products of all kinds, to expose the dangers inherent in our factory farming system, and to advocate a complete plant-based diet. The bok garnered endorsements by everyone from Paul Hawken to Neal Donald Walsch, Marianne Williamson to Julia Butterfly Hill. After ten years in print, The Food Revolution is timelier than ever—and a very compelling read. The 10th anniversary edition has an updated, new contemporary look and a new introduction by the author.

Bone Cancer

Author: Dominique Heymann
Publisher: Academic Press
ISBN: 9780080953885
Size: 15.53 MB
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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Inflammation And Metastasis

Author: Yoshiro Maru
Publisher: Springer
ISBN: 4431560246
Size: 61.74 MB
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This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.

Stem Cells

Author: Ariff Bongso
Publisher: World Scientific
ISBN: 9814289388
Size: 27.46 MB
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Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.

Stem Cell Biology In Health And Disease

Author: Thomas Dittmar
Publisher: Springer Science & Business Media
ISBN: 9789048130405
Size: 43.95 MB
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Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Resistance To Targeted Therapies In Breast Cancer

Author: Jenifer R. Prosperi
Publisher: Springer
ISBN: 3319701428
Size: 11.48 MB
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We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). We have also provided an overview of standard of care as an introduction into the importance of targeted therapy. It is our hope that this volume gives an insight into the landscape of breast cancer treatment, the challenges of targeted therapy, and a glimpse into the future of breast cancer therapy.

Stem Cells Current Challenges And New Directions

Author: Kursad Turksen
Publisher: Springer Science & Business Media
ISBN: 1461480663
Size: 43.54 MB
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This volume looks at the state-of-the-science in stem cells, discusses the current challenges, and examines the new directions the field is taking. Dr. Turksen, editor-in-chief of the journal "Stem Cell Reviews and Reports," has assembled a volume of internationally-known scientists who cover topics that are both clinically and research-oriented. The contents range from sources of stem cells through their physiological role in health and disease, therapeutic applications in regenerative medicine, and ethics and society. An initial overview and a final summary bookend the contents into a cohesive and invaluable volume.

Lung Cancer Metastasis

Author: Venkateshwar Keshamouni
Publisher: Springer Science & Business Media
ISBN: 1441907726
Size: 52.28 MB
Format: PDF, Kindle
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Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery.