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Cancer Stem Cells

Author: Huiping Liu
Publisher: Elsevier
ISBN: 0128039345
Size: 68.54 MB
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Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cells Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells Deepens a reader’s technical expertise in cancer stem cell biology

Chance Necessity Love

Author: Leonard M. Hummel
Publisher: Wipf and Stock Publishers
ISBN: 1498284531
Size: 33.65 MB
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What exactly is cancer? And where is God and what is love amidst the complex evolutionary development of all cancers? In Chance, Necessity, Love: An Evolutionary Theology of Cancer, Hummel and Woloschak address these questions that arise for many people with cancer and in all who grapple with making meaning of science about cancers. In order to do so, the authors first clarify new scientific findings about cancer and then offer faithful and wise theological perspectives on these discoveries. In doing so, they make plain what cannot and can be changed about cancer. And, in doing so, they show how cancer is an evolutionary disease that develops according to the same dynamics of chance (that is, random occurrences) and necessity (law-like regularities) at work in all other evolutionary phenomena. Therefore, they ask: where is God and what is love within the evolutionary chance and necessity operative throughout all aspects of cancer? They offer the readers thoughtful responses to this question and many others—life, death, hope, acceptance, and love—given the evolutionary nature of cancer.

The Food Revolution

Author: John Robbins
Publisher: Conari Press
ISBN: 9781609252922
Size: 69.55 MB
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In 1987, John Robbins published Diet for a New America, which was an early version of this book, and he started the food revolution. He continues to work tirelessly to promote conscious food choices more than 20 years later. First published in 2001, The Food Revolution is still one of the most frequently cited and talked about books of the food-politics revolution. It was one of the very first books to discuss the negative health effects of eating genetically modified foods and animal products of all kinds, to expose the dangers inherent in our factory farming system, and to advocate a complete plant-based diet. The bok garnered endorsements by everyone from Paul Hawken to Neal Donald Walsch, Marianne Williamson to Julia Butterfly Hill. After ten years in print, The Food Revolution is timelier than ever—and a very compelling read. The 10th anniversary edition has an updated, new contemporary look and a new introduction by the author.

Cancer Stem Cells

Author: Otmar D. Wiestler
Publisher: Springer Science & Business Media
ISBN: 3540708537
Size: 76.98 MB
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Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.

Stem Cells And Prostate Cancer

Author: Scott D. Cramer
Publisher: Springer Science & Business Media
ISBN: 1461464986
Size: 58.67 MB
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​​​​Recent evidence demonstrates that normal prostate tissue contains stem cells. There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells. Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer. The purpose of this book is to explore the role of stem cells in prostate cancer, which is becoming an increasingly hot trend in cancer research. ​

Cancer Targeted Drug Delivery

Author: You Han Bae
Publisher: Springer Science & Business Media
ISBN: 1461478766
Size: 43.76 MB
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This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.

Perspectives In Cancer Prevention Translational Cancer Research

Author: Perumana R. Sudhakaran
Publisher: Springer Science & Business Media
ISBN: 8132215338
Size: 74.77 MB
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Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer , morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention. A few contributions from this meeting are presented in this book, providing an in depth analysis of data on cancer prevention and therapeutics. These contributions are either critical reviews or research reports. The topics discussed include evidence-based nutritional recommendations for cancer patients and survivors, risk factors such as stress, enrichment of tumour stem cells by anticancer drug treatment contributing to tumour recurrence and the mechanism of anticancer effects of various natural products. Chemosensitizing effect of curcumin, anti-cancer effect of products from neem, action of sulforaphane and cytotoxic effect of a number of novel synthetic coordination complexes of trace metals have been discussed. Novel molecular targets of angiogenesis and molecular basis of the gender bias to thyroid cancer have also been discussed . This book provides useful information on translational cancer research to clinicians and biomedical scientists.

Systems Biology Of Cancer

Author: Sam Thiagalingam
Publisher: Cambridge University Press
ISBN: 0521493390
Size: 78.72 MB
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An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Cancer Stem Cells In Solid Tumors

Author: Alison L. Allan
Publisher: Springer Science & Business Media
ISBN: 1617792462
Size: 77.37 MB
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The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cell Cycle Inhibitors In Cancer Therapy

Author: Antonio Giordano
Publisher: Springer Science & Business Media
ISBN: 1592594018
Size: 40.33 MB
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Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease.