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Central Nervous System Diseases And Inflammation

Author: Thomas E. Lane
Publisher: Springer Science & Business Media
ISBN: 9780387738949
Size: 80.45 MB
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Edited and authored by top names in the field, this book provides a succinct reference on inflammatory central nervous system disease. It focuses on current areas of investigation in the fields of neuroimmunology, virology, pharmacology, and disease. Sections focus on specific categories of diseases, examining the pharmacological, virological, and immunological effects of and on the disease. This book’s unique organization provides a concise overview of inflammatory CNS disease.

Inflammatory Disorders Of The Nervous System

Author: Alireza Minagar
Publisher: Humana Press
ISBN: 331951220X
Size: 48.23 MB
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This thoroughly updated edition covers all clinical aspects of neuroinflammation. The latest developments in pathogenesis and advances in treatment are provided, along with an understanding of the immune system's role and interactions between the activated immune cells, cerebral endothelial cells, and other main components of the immune cascade. Cutting-edge and authoritative, this volume offers practitioners a valuable resource for research and clinical practice.

Inflammation In Central Nervous System Diseases

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Abstract: Inflammation is implicated in the pathogenesis of various central nervous system diseases. The brain is a sterile organ; therefore, inflammation is triggered by endogenous molecules. Pattern recognition receptors recognize specific endogenous molecules, and activate resident glial cells and peripheral immune cells. Inflammasome complex formation is also important for neuroinflammation in brain tissue injury, epilepsy and neurodegenerative diseases. Although inflammation exaggerates the pathology and neurological deficits in neurological disorders, triggering the pro‐resolution process and neuronal repair is a beneficial side of inflammation. We introduce recent accumulating evidence about the relationship between neuroinflammation by innate immunity and the process of pathogenesis in central nervous system diseases. Abstract : Inflammation is implicated in the pathogenesis of various central nervous system (CNS) diseases. Pattern recognition receptors recognize specific endogenous molecules and activate resident glial cells and peripheral immune cells. Inflammation exaggerates the pathology and neurological deficits in neurological disorders; while, triggering the pro‐resolution process and neuronal repair is a beneficial side of inflammation.

Immunological And Inflammatory Disorders Of The Central Nervous System

Author: Neil Scolding
Publisher: Butterworth-Heinemann Medical
Size: 69.55 MB
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A variety of diseases which are driven by immunological and inflammatory disturbances can affect the central nervous system; some are primary neurological conditions, e.g. multiple sclerosis, whilst other CNS diseases reflect an inflammatory disorder, e.g. vasculitis. The clinical features, immunological background and treatment of these primary and secondary disorders of the CNS are the subject of this book.

Induction Of Central Nervous System Disease By The Adaptive Immune Response

Author: Robert Weissert
Publisher: Frontiers Media SA
ISBN: 2889453472
Size: 58.43 MB
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Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.

Inflammatory Diseases Of The Central Nervous System

Author: Trevor Kilpatrick
Publisher: Cambridge University Press
ISBN: 9780521888745
Size: 62.35 MB
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Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists.

Neuroinflammation And Cns Disorders

Author: Nicola Woodroofe
Publisher: John Wiley & Sons
ISBN: 1118406540
Size: 73.62 MB
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The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has opened up new avenues for therapeutic approaches to treatment of CNS inflammatory and neurodegenerative disorders. Neuroinflammation and CNS Disorders brings together the very latest information on the interactions between the immune system and central nervous system. The first section of the book highlights the basic concepts in the field whilst the second section, the main body of the book, covers the role of the immune response in specific disorders of the central nervous system. Neuroinflammation and CNS Disorders will provide an invaluable guide for both researchers and clinicians working in this complex and dynamic field.


Author: Nejat Duzgunes
Publisher: Academic Press
ISBN: 012391860X
Size: 64.54 MB
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This volume comprehensively covers cancer, cardiovascular and the central nervous system of nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as diabetes and nanotechnology as potential therapy, and nanomedicines for inflammatory diseases.

Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases

Author: Jean-Louis Junien
Publisher: IOS Press
ISBN: 1586038575
Size: 55.96 MB
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Focuses on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders. This book also focuses on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders, and on the aspects of drug finding.

Inflammatory And Autoimmune Disorders Of The Nervous System In Children

Author: Russell C. Dale
Publisher: John Wiley & Sons
ISBN: 1898683662
Size: 76.37 MB
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Inflammatory disorders of the nervous system, although individually uncommon, collectively make up 10-20% of acute paediatric neurology presentations and many are potentially treatable. Research into them is lagging behind adult research, but better diagnosis and often simple treatments could lead to substantial clinical benefit and reduction in long-term disability. This book provides a detailed and comprehensive summary of the childhood diseases that are, or are likely to be, caused by the immune system. The authors not only describe these disorders and their treatments comprehensively, helping pediatricians and pediatric neurologists to improve their understanding and recognition of the conditions, but also highlight recent and exciting developments that will be of considerable importance in the future.