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Channels Carriers And Pumps

Author: Wilfred D. Stein
Publisher: Elsevier
ISBN: 0124165834
Size: 37.22 MB
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An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. Provides an introduction to the properties of transport proteins: channels, carriers, and pumps Presents up-to-date information on the structure of transport proteins and on their function and regulation Includes introductions to transport kinetics and to the cloning of genes that code transport proteins Furnishes a link between the experimental basis of the subject and theoretical model building

Channels Carriers And Pumps

Author: Wilfred D. Stein
Publisher: Elsevier
ISBN: 0323138152
Size: 43.89 MB
Format: PDF, Mobi
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For students as well as researchers this book describes the exciting new advances in the molecular biology of transport proteins and integrates this information with transport kinetics, function, and regulation. Experimental data are linked with theory. Provides an introduction to the properties of transport proteins: channels, carriers, and pumps Presents up-to-date information on the structure of transport proteins and on their function and regulation Includes introductions to transport kinetics and to the cloning of genes that code transport proteins Furnishes a link between the experimental basis of the subject and theoretical model building

Channels Carriers And Pumps An Introduction To Membrane Transport

Author: Wilfred D. Stein
Publisher: Academic Press
ISBN: 9780128102923
Size: 30.44 MB
Format: PDF, ePub
View: 7572
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An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships.The regulation of transporters and their role in health and disease are also considered. Provides an introduction to the properties of transport proteins: channels, carriers, and pumpsPresents up-to-date information on the structure of transport proteins and on their function and regulationIncludes introductions to transport kinetics and to the cloning of genes that code transport proteinsFurnishes a link between the experimental basis of the subject and theoretical model building "

Transport And Diffusion Across Cell Membranes

Author: Wilfred Stein
Publisher: Elsevier
ISBN: 0323143202
Size: 55.58 MB
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Transport and Diffusion across Cell Membranes is a comprehensive treatment of the transport and diffusion of molecules and ions across cell membranes. This book shows that the same kinetic equations (with appropriate modification) can describe all the specialized membrane transport systems: the pores, the carriers, and the two classes of pumps. The kinetic formalism is developed step by step and the features that make a system effective in carrying out its biological role are highlighted. This book is organized into six chapters and begins with an introduction to the structure and dynamics of cell membranes, followed by a discussion on how the membrane acts as a barrier to the transmembrane diffusion of molecules and ions. The following chapters focus on the role of the membrane's protein components in facilitating transmembrane diffusion of specific molecules and ions, measurements of diffusion through pores and the kinetics of diffusion, and the structure of such pores and their biological regulation. This book methodically introduces the reader to the carriers of cell membranes, the kinetics of facilitated diffusion, and cotransport systems. The primary active transport systems are considered, emphasizing the pumping of an ion (sodium, potassium, calcium, or proton) against its electrochemical gradient during the coupled progress of a chemical reaction while a conformational change of the pump enzyme takes place. This book is of interest to advanced undergraduate students, as well as to graduate students and researchers in biochemistry, physiology, pharmacology, and biophysics.

Neurotransmitter Transporters

Author: Susan Gaye Amara
Publisher: Gulf Professional Publishing
ISBN: 9780121821975
Size: 13.37 MB
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General Description of the Series: Neurotransmitter Transporters focuses on biochemical, electrophysiological, pharmacological, molecular, and cell biological approaches used to study neurotransmitter transport systems. The articles provide detailed descriptions of procedures that should enable the reader to understand how they are accomplished and to repeat or adapt them for their own experimental needs. This book is the first to focus on methods that have been the basis for the rapid development of this area. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * The transport of CNS neurotransmitter transporters * Electrophysiological, biochemical, molecular, cellular biological, pharmacological, neurochemical, and structural approaches * Both plasma and vesicular carriers

Exploring The Cell Membrane Conceptual Developments

Author: A. Kleinzeller
Publisher: Newnes
ISBN: 0444598197
Size: 54.87 MB
Format: PDF, Docs
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The suggestion for this collection of essays originated in part from a course given to graduate students at the University of Pennsylvania School of Medicine. In sections of this course, the conceptual developments in the fields of membrane transport and cellular respiration were traced to illustrate general aspects of the development of ideas in a scientific field. Discussions with peers on the topic also greatly enhanced the development of the project as it is reflected in this book. The volume reflects the breadth and scope of this rapidly developing field, and is an excellent treatise of a historical evaluation of how this field has developed.

Transport In Biological Media

Author: Sid Becker
Publisher: Newnes
ISBN: 0123978491
Size: 20.56 MB
Format: PDF, Kindle
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Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. Provides detailed mathematical model development to interpret experiments and provides current modeling practices Provides a wide range of biological and clinical applications Includes physiological descriptions of models

The Structural Basis Of Membrane Function

Author: Youssef Hatafi
Publisher: Academic Press
ISBN: 0323148026
Size: 19.69 MB
Format: PDF
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The Structural Basis of Membrane Function is a documentation of an international symposium of the same title. This book serves as a collection of the significant articles pertaining to the field of membrane research. It is composed of seven parts, where the first and last parts are articles contributed by scientific authorities. The book generally discusses the membrane research and this study’s relevance to the society. Then, the book specifically looks into membrane features, including its structure, processes in it, functions, and types. Some of the specific topics included in the discussion of each part are phospholipases and monolayers used in studies of membrane structure; molecular aspects of active transport; and electron-transfer in energy-transducing membranes. The book also explains the two functions in common of biological membranes; synaptic receptor proteins; and liver microsomal membranes. The scope of this book is broad and helpful to many fields of scienec. It will be of great benefit to students, teachers, scientists, and researchers in the field of biochemistry, biology, molecular biology, chemistry, pharmacology, and cellular biology among others.

Red Cell Membrane Transport In Health And Disease

Author: Ingolf Bernhardt
Publisher: Springer Science & Business Media
ISBN: 3662051818
Size: 80.12 MB
Format: PDF, Mobi
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51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Concepts In Biochemistry

Author: Rodney F. Boyer
Publisher: Wiley
ISBN: 9780471661795
Size: 26.27 MB
Format: PDF, ePub
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The third edition of Concepts in Biochemistry makes the most applied and accessible biochemistry text on the market. Students are more successful with Boyer because it isn't intimidating and it makes clear the relevance of the material to their future careers. Like the first two editions, Boyer is written for students who need an introduction to the fundamental principles of biochemistry and are preparing for a career in the allied health sciences, the biological sciences, and the environmental sciences. (The text is also appropriate for use in one-semester courses developed for chemistry majors as a result of the new American Chemical Society requirements for three-credit hours of biochemistry coursework.) The modern, student-friendly organization sets the book apart from the competition because the early placement of nucleic acids enhances the traditional coverage of protein structure and function, and metabolism. As an example, it is now possible to present metabolism in a more contemporary fashion, emphasizing gene regulation and integration. Rod Boyer is a recently retired Professor of Chemistry and Biochemistry at Hope College in Holland, Michigan. He has a PhD from Colorado State and recently spent a sabbatical year at Nobel Prize winner Tom Cech's lab at the University of Colorado. He is on the Editorial Board for the journal, Biochemistry and Molecular Biology Education and has been very active in education affairs for the American Society for Biochemistry and Molecular Biology.