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Channels Carriers And Pumps

Author: Wilfred D. Stein
Publisher: Academic Pr
ISBN:
Size: 17.87 MB
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For students as well as researchers this book describes the exciting new advances in the molecular biology of transport proteins and integrates this information with transport kinetics, function, and regulation. Experimental data are linked with theory. Key Features * Provides an introduction to the properties of transport proteins: channels, carriers, and pumps * Presents up-to-date information on the structure of transport proteins and on their function and regulation * Includes introductions to transport kinetics and to the cloning of genes that code transport proteins * Furnishes a link between the experimental basis of the subject and theoretical model building.

Channels Carriers And Pumps

Author: Wilfred D. Stein
Publisher: Elsevier
ISBN: 0124165834
Size: 44.48 MB
Format: PDF
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An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered. Provides an introduction to the properties of transport proteins: channels, carriers, and pumps Presents up-to-date information on the structure of transport proteins and on their function and regulation Includes introductions to transport kinetics and to the cloning of genes that code transport proteins Furnishes a link between the experimental basis of the subject and theoretical model building

Neurotransmitter Transporters

Author: Susan G. Amara
Publisher: Gulf Professional Publishing
ISBN: 9780121821975
Size: 37.30 MB
Format: PDF, Mobi
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General Description of the Series: Neurotransmitter Transporters focuses on biochemical, electrophysiological, pharmacological, molecular, and cell biological approaches used to study neurotransmitter transport systems. The articles provide detailed descriptions of procedures that should enable the reader to understand how they are accomplished and to repeat or adapt them for their own experimental needs. This book is the first to focus on methods that have been the basis for the rapid development of this area. General Description of the Series: The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Key Features * The transport of CNS neurotransmitter transporters * Electrophysiological, biochemical, molecular, cellular biological, pharmacological, neurochemical, and structural approaches * Both plasma and vesicular carriers

Molekularbiologie Der Zelle

Author: Bruce Alberts
Publisher: John Wiley & Sons
ISBN: 3527323848
Size: 49.24 MB
Format: PDF
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Seit einem Vierteljahrhundert ist 'Molekularbiologie der Zelle' das führende Lehrbuch im Bereich Zellbiologie. Diese erfolgreiche Tradition wird nun mit der fünften Auflage fortgesetzt, die vollständig überarbeitet und aktualisiert wurde. Mit zahlreichen inhaltlichen Neuerungen stellt sie unser aktuelles, sich rasch weiterentwickelndes Wissens zum zentralen Gegenstand der Biologie dar - der Zelle.

More Landmarks In Biochemistry

Author: L.A. Stocken
Publisher: Elsevier
ISBN: 9780080531915
Size: 46.86 MB
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This fourth volume in the series on biochemistry looks at foundations in modern biochemistry. Topics covered include: the genetic solution; the genetic basis of development; DNA repair; evolution in an RNA world; nitrogen fixation; solute channels; viruses; biochemistry in retrospect and propspect.

Stryer Biochemie

Author: Jeremy M. Berg
Publisher: Springer-Verlag
ISBN: 3827429897
Size: 69.85 MB
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Der Klassiker unter den Biochemie-Lehrbüchern – seit Jahrzehnten international bewährt, von Lehrenden und Lernenden hoch geschätzt und jetzt wieder auf dem neuesten Stand Diese vollständig überarbeitete Neuauflage weist all die innovativen konzeptionell-didaktischen und herausragenden gestalterischen Eigenschaften auf, die schon die früheren Auflagen zu Bestsellern gemacht haben – die außerordentlich klare und präzise Art der Darstellung, die Aktualität, die ausgefeilte Didaktik, die Verständlichkeit. In gewohnt verständlicher Form greift das Buch auch jüngste Fortschritte auf dem Gebiet der Biochemie auf. Es veranschaulicht den „Kern“ der Biochemie – die Schlüsselkonzepte und Grundprinzipien –, schlägt Brücken zwischen verschiedenen Befunden und Untersuchungsansätzen und offenbart damit letztlich sowohl die molekulare Logik des Lebendigen als auch die Bedeutung der Biochemie für die Medizin. Studierende und Lehrende werden unter anderem folgende Neuerungen und Verbesserungen in der 7. Auflage zu schätzen wissen: - erweiterte Darstellung der Genregulation bei Prokaryoten (Kapitel 31) und Eukaryoten (Kapitel 32) mit zahlreichen neuen Abschnitten, etwa zum quorum sensing, zur Induktion pluripotenter Stammzellen und zur Funktion der Mikro-RNAs - Integration neuer Forschungsergebnisse zum Zusammenhang zwischen Stoffwechsel, Ernährung und Fettleibigkeit sowie zur Bedeutung der Leptine - Berücksichtigung zahlreicher wissenschaftlicher Fortschritte zu DNA-Sequenzierung, Myosin, Glykomik, Vogelgrippe, Endocytose, Cholesterin, Helikasen,, Riboswitches u. v. m. - erweiterte Darstellung wichtiger Labormethoden - neue Beispiele für medizinische Zusammenhänge und klinische Anwendungen - deutlich mehr Übungsaufgaben an den Kapitelenden - zusätzliche Informationen, Materialien und Lernhilfen, etwa interaktive Molekülmodelle und Animationen, im Internet (englischsprachig) - die Abbildungen des Buches in elektronischer Form für den Einsatz in der Lehre

Transport And Diffusion Across Cell Membranes

Author: Wilfred Stein
Publisher: Elsevier
ISBN: 0323143202
Size: 44.67 MB
Format: PDF, Kindle
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Transport and Diffusion across Cell Membranes is a comprehensive treatment of the transport and diffusion of molecules and ions across cell membranes. This book shows that the same kinetic equations (with appropriate modification) can describe all the specialized membrane transport systems: the pores, the carriers, and the two classes of pumps. The kinetic formalism is developed step by step and the features that make a system effective in carrying out its biological role are highlighted. This book is organized into six chapters and begins with an introduction to the structure and dynamics of cell membranes, followed by a discussion on how the membrane acts as a barrier to the transmembrane diffusion of molecules and ions. The following chapters focus on the role of the membrane's protein components in facilitating transmembrane diffusion of specific molecules and ions, measurements of diffusion through pores and the kinetics of diffusion, and the structure of such pores and their biological regulation. This book methodically introduces the reader to the carriers of cell membranes, the kinetics of facilitated diffusion, and cotransport systems. The primary active transport systems are considered, emphasizing the pumping of an ion (sodium, potassium, calcium, or proton) against its electrochemical gradient during the coupled progress of a chemical reaction while a conformational change of the pump enzyme takes place. This book is of interest to advanced undergraduate students, as well as to graduate students and researchers in biochemistry, physiology, pharmacology, and biophysics.