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Chromosomal Translocations And Genome Rearrangements In Cancer

Author: Janet D. Rowley
Publisher: Springer
ISBN: 3319199838
Size: 12.41 MB
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This volume collates world experts’ insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible. The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics. Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours. Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.

Advances In Cancer Research

Author:
Publisher: Academic Press
ISBN: 0123978416
Size: 51.57 MB
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. 113th volume of Advances in Cancer Research Expert authors Chapters on topics including microRNA regulatory network, multifaceted oncoprotein tax, and underlying chromosomal translocations

Mechanisms Of Dna Recombination And Genome Rearrangements Intersection Between Homologous Recombination Dna Replication And Dna Repair

Author:
Publisher: Academic Press
ISBN: 0128139803
Size: 56.34 MB
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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability documents cutting edge methods

Chronic Myeloproliferative Disorders

Author: Barbara J. Bain
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805573073
Size: 61.56 MB
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This publication provides a comprehensive and up-to-date review of the significance of cytogenetic and molecular genetic abnormalities in the chronic myeloid leukaemias and other myeloproliferative disorders. This book will therefore be an important reference text, not only for haematologists, but also for molecular geneticists and cytogeneticists, and anyone involved in leukaemia research.

Cancer Cytogenetics

Author: Sverre Heim
Publisher: John Wiley & Sons
ISBN: 1118795539
Size: 69.37 MB
Format: PDF
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The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. New contributors reflecting broader international authorship and even greater expertise Greater emphasis throughout on the clinical importance and application of information about cytogenetic and molecular aberrations Includes a complete coverage of chromosome aberrations in cancer based on an assessment of the 60,000 neoplasms cytogenetically investigated to date Now produced in full color for enhanced clarity Covers how molecular genetic data (PCR-based and sequencing information) are collated with the cytogenetic data where pertinent Discusses how molecular cytogenetic data (based on studies using FISH, CGH, SNP, etc) are fused with karyotyping data to enable an as comprehensive understanding of cancer cytogenetics as is currently possible

Genomic Disorders

Author: James R. Lupski
Publisher: Springer Science & Business Media
ISBN: 1597450391
Size: 63.94 MB
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A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrate how such architectural features may be important to both evolution and to explaining the susceptibility to those DNA rearrangements associated with disease. Technologies to assay for such structural variation of the human genome and to model genomic disorders in mice are also presented. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.

Modern Genetic Analysis

Author: Anthony J.F. Griffiths
Publisher: Macmillan
ISBN: 9780716743828
Size: 73.78 MB
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Part 1: Fundamentals of gene structure, function, and transmission; Genetics and the organism; The structure of genes and genomes; Gene function; The transmission of DNA at cell division; The inheritance of single-gene differences; Genetic recombination in eukaryotes; Recombination in bacteria and their viruses. Part 2: Methods of genetic manipulation; Recombinant DNA and genetic engineering; Genomics; Gene mutation: origins and repair processes; Chromosome mutations; Mutation dissection. Part 3: Systems genetics: from gene to phenotype; Regulation of hene transciption; From gene to phenotype; Regulation of cell number: normal and cancer cells; The genetic basis of development. Part 4: Genetic analysis of populations; Population genetics; Quantitative genetics; Evolutionary genetics.

Genome And Disease

Author: Jean-Nicolas Volff
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805580290
Size: 50.40 MB
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Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important 'caretaker' genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.