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Combinatorial Chemistry And Technologies

Author: Stanislav Miertus
Publisher: CRC Press
ISBN: 9780824758370
Size: 16.10 MB
Format: PDF
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Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Molecular Diversity And Combinatorial Chemistry

Author: Michael C. Pirrung
Publisher: Elsevier
ISBN: 9780080445328
Size: 26.21 MB
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Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Solid Phase Synthesis And Combinatorial Technologies

Author: Pierfausto Seneci
Publisher: John Wiley & Sons
ISBN: 0471460737
Size: 69.11 MB
Format: PDF, Mobi
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A unique, integrated look at solid-phase synthesis and advancesin combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorialtechnologies, a field where chemistry disciplines intersect withautomation, statistics, and information science, as well as certainbiological disciplines. Reflecting these multidisciplinary trends,this new work provides a comprehensive overview of the mostimportant aspects of solid-phase synthesis (SPS), combinatorialchemistry, and related combinatorial technologies. It clearlydemonstrates how SPS and combinatorial chemistry have extendedtheir application from the pharmaceutical arena to new areas,including biotechnology, material sciences, catalysis, andagrochemical industries, and explores in detail strategies forplanning, designing, preparing, and testing of combinatoriallibraries in various disciplines. Designed to meet the needs ofboth experienced combinatorial chemists and newcomers to the field,Solid-Phase Synthesis and CombinatorialTechnologies: Surveys the most recent developments in SPS and combinatorialchemistry Explains the entire process, from determining the need for alibrary to the details necessary for synthesis of the library Discusses choice of format, size, and the rationale behind thedesign of each synthetic step Surveys the analytical techniques and the purification methodsused to characterize and purify combinatorial libraries Employs a large number of examples to illustrate importantconcepts Includes problems geared toward applying acquired knowledge anddesigning the steps to SPS/library synthesis Describes the quality control and activity screening ofcombinatorial libraries for various applications Features a detailed bibliography of more than 1,700 relevantsources

Integrated Drug Discovery Technologies

Author: Houng-Yau Mei
Publisher: CRC Press
ISBN: 9780203910696
Size: 21.58 MB
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Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Polymeric Materials In Organic Synthesis And Catalysis

Author: Michael R. Buchmeiser
Publisher: Wiley-VCH
ISBN: 9783527306305
Size: 59.12 MB
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This is the first book to describe the synthesis and characterization of the materials used in polymer-supported synthesis. The authors cover not only the classical polymers and their use in homogeneous, heterogeneous and micellar catalysis, but also such new developments as "enzyme-labile linkers", illustrating how to simplify the purification process and avoid waste. The result is a wealth of useful information -- for beginners and experts alike - in one handy reference, removing the need for difficult and time-consuming research among the literature.

Analysis And Purification Methods In Combinatorial Chemistry

Author: Bing Yan
Publisher: John Wiley & Sons
ISBN: 9780471531999
Size: 50.21 MB
Format: PDF, ePub
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Quality measurement, control, and improvement in combinatorialchemistry Combinatorial chemistry has developed rapidly in the past decade,with great advances made by scientists working on analysis andpurification of a large number of compounds and the analysis ofpolymer-bound compounds. However, formidable challenges lie aheadof today's researcher. For example, high-throughput analysis andpurification technologies must be further developed to ensurecombinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in CombinatorialChemistry describes various analytical techniques and systems forthe development, validation, quality control, purification, andphysicochemical testing of combinatorial libraries. A new volume inWiley's Chemical Analysis series, this text has four partscovering: * Various approaches to monitoring reactions on solid support andoptimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality oflibraries * High-throughput purification techniques * Analytical methods applied in post-synthesis andpost-purification stages Drawing from the contributions of respected experts incombinatorial chemistry, this comprehensive book provides coverageof applications of Nuclear Magnetic Resonance (NMR), liquidchromatography/mass spectrometry (LC/MS), Fourier TransformInfrared (FTIR), micellar electrokinetic chromatography (MEKC)technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to thelibrary of students and researchers studying or working inanalytical chemistry, combinatorial chemistry, medicinal chemistry,organic chemistry, biotechnology, biochemistry, or biophysics.

Combinatorial Chemistry

Author: Willi Bannwarth
Publisher: John Wiley & Sons
ISBN: 3527607382
Size: 40.87 MB
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The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)