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Combinatorial Chemistry And Technologies

Author: Stanislav Miertus
Publisher: CRC Press
ISBN: 9780824758370
Size: 39.45 MB
Format: PDF, ePub
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Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Molecular Diversity And Combinatorial Chemistry

Author: Michael C. Pirrung
Publisher: Elsevier
ISBN: 9780080444932
Size: 51.69 MB
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Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Combinatorial Chemistry

Author: Willi Bannwarth
Publisher: John Wiley & Sons
ISBN: 3527607382
Size: 18.48 MB
Format: PDF, ePub
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The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

Integrated Drug Discovery Technologies

Author: Houng-Yau Mei
Publisher: CRC Press
ISBN: 9780203910696
Size: 56.79 MB
Format: PDF, ePub, Docs
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Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Solid Phase Synthesis And Combinatorial Technologies

Author: Pierfausto Seneci
Publisher: John Wiley & Sons
ISBN: 0471460737
Size: 78.87 MB
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A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: Surveys the most recent developments in SPS and combinatorial chemistry Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library Discusses choice of format, size, and the rationale behind the design of each synthetic step Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries Employs a large number of examples to illustrate important concepts Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis Describes the quality control and activity screening of combinatorial libraries for various applications Features a detailed bibliography of more than 1,700 relevant sources

Analysis And Purification Methods In Combinatorial Chemistry

Author: Bing Yan
Publisher: John Wiley & Sons
ISBN: 9780471531999
Size: 36.41 MB
Format: PDF, Kindle
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Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.