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Dementia With Lewy Bodies

Author: John O'Brien
Publisher: CRC Press
ISBN: 9780203313909
Size: 61.22 MB
Format: PDF
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Filling a noticeable gap in the market for a new text solely focused on Dementia with Lewy Bodies, this book discusses cutting-edge topics covering the condition from diagnosis to management, as well as what is known about the neurobiological changes involved. With huge progress having been made over the last decade in terms of the disorder's recognition as a common cause of cognitive impairment, its clinical features, its underlying neurobiology, investigative changes, and management, this is undoubtedly a much-needed work in what is an important and rapidly progressing field.

Demenz

Author: Dave Pulsford
Publisher: Junfermann Verlag GmbH
ISBN: 3955715779
Size: 70.17 MB
Format: PDF
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Unter einer Demenz leiden oder mit Demenz leben? Eine Demenzerkrankung stellt für Angehörige und Freunde des Erkrankten eine enorme Herausforderung dar. Ein Mensch, den man so gut kannte, verändert sich auf unbegreifliche Weise – mit Konsequenzen auch für das eigene Leben. Dave Pulsford und Rachel Thompson erläutern Schritt für Schritt, wie eine Demenzerkrankung verläuft. Sie nehmen Angehörige und Pflegende mit auf eine Reise in die Welt der Demenz und erklären, was mit dem erkrankten Menschen passiert und auch, welche Auswirkungen die Erkrankung auf das Umfeld hat. Wo kann man sich informieren? Wo findet man Unterstützung? Eine Demenz schreitet ständig fort, und so müssen auch Angehörige sich dem weiteren Verlauf der Erkrankung immer wieder anpassen. Auch hier bietet das Buch Unterstützung, mit dem Ziel einer möglichst hohen Lebensqualität für Erkrankte und Angehörige.

Demenz

Author: Dave Pulsford
Publisher: Junfermann Verlag GmbH
ISBN: 3955715752
Size: 52.55 MB
Format: PDF, Mobi
View: 459
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Unter einer Demenz leiden oder mit Demenz leben? Eine Demenzerkrankung stellt für Angehörige und Freunde des Erkrankten eine enorme Herausforderung dar. Ein Mensch, den man so gut kannte, verändert sich auf unbegreifliche Weise – mit Konsequenzen auch für das eigene Leben. Dave Pulsford und Rachel Thompson erläutern Schritt für Schritt, wie eine Demenzerkrankung verläuft. Sie nehmen Angehörige und Pflegende mit auf eine Reise in die Welt der Demenz und erklären, was mit dem erkrankten Menschen passiert und auch, welche Auswirkungen die Erkrankung auf das Umfeld hat. Wo kann man sich informieren? Wo findet man Unterstützung? Eine Demenz schreitet ständig fort, und so müssen auch Angehörige sich dem weiteren Verlauf der Erkrankung immer wieder anpassen. Auch hier bietet das Buch Unterstützung, mit dem Ziel einer möglichst hohen Lebensqualität für Erkrankte und Angehörige.

Dementia With Lewy Body And Parkinson S Disease Patients

Author: J. Eric Ahlskog
Publisher: Oxford University Press
ISBN: 0199977569
Size: 50.69 MB
Format: PDF
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Dementia implies impaired thinking and memory, which develops in most people with Parkinson's disease if they live long enough. A closely related condition is Dementia with Lewy Bodies, which is the second leading cause of dementia. This book addresses these Lewy body conditions, with descriptions of diagnosis, symptoms, and current scientific understanding.

Neuroinflammation In Lewy Body Dementia

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Publisher:
ISBN:
Size: 37.28 MB
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Abstract: Neuroinflammation is increasingly recognized as a key factor in the pathogenesis of neurodegenerative conditions. However, it remains unclear whether it has a protective or damaging role. Studies of Alzheimer's disease and Parkinson's disease have provided much of the evidence for inflammatory pathology in neurodegeneration. Here we review the evidence for inflammation in dementia with Lewy bodies and Parkinson's disease dementia. Neuroinflammation has been confirmed invivo using PET imaging, with microglial activation seen in Parkinson's disease dementia and recently in dementia with Lewy bodies. In Parkinson's disease and Parkinson's disease dementia, microglial activation suggests a chronic inflammatory process, although there is also evidence of its association with cognitive ability and neuronal function. Alpha-synuclein in various conformations has also been linked to activation of microglia, with a broad range of components of the innate and adaptive immune systems associated with this interaction. Evidence of neuroinflammation in Lewy body dementia is further supported by pathological and biomarker studies. Genetic and epidemiological studies support a role for inflammation in Parkinson's disease, but have yet to provide the same for Lewy body dementia. This review highlights the need to identify whether the nature and extent of microglial activation in Lewy body dementia can be linked to structural change, progression of domain specific cognitive symptoms and peripheral inflammation as a marker of central microglial pathology. Answers to these questions will enable the evaluation of immunotherapies as potential therapeutic options for prevention or treatment of dementia with Lewy bodies and Parkinson's disease dementia. Highlights: We review the evidence for inflammation in Lewy body dementia. Microglial activation is seen invivo in Lewy body dementia. Alpha-synuclein in various conformations can activate microglia. Pathological and biomarker studies provide further evidence of inflammation. Future studies need to link microglia with symptoms and structural change.

Cognitive Impairment And Dementia In Parkinson S Disease

Author: Murat Emre
Publisher: Oxford University Press, USA
ISBN: 0199681643
Size: 74.57 MB
Format: PDF, Mobi
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In this edited volume, experts on the treatment of dementia associated with Parkinson's Disease (PD) describes in detail the current status of knowledge in their respective area of expertise. The importance and clinical relevance of cognitive impairment and dementia in PD is emphasized, all relevant aspects including epidemiology, full and detailed spectrum of clinical features, current knowledge on pathology, neurochemistry and genetics, findings in auxillary investigations, relation to other neurodegenerative disorders, diagnostic process and management are described, rounded-up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and is heavily referenced thereby capturing all relevant literature.

Structural And Functional Imaging Study In Dementia With Lewy Bodies And Parkinson S Disease Dementia

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Publisher:
ISBN:
Size: 36.20 MB
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Abstract Introduction Dementia with Lewy Bodies (DLB) and Parkinson's disease with Dementia (PDD) are neurodegenerative disorders with complex clinical picture (parkinsonism, cognitive decline and neuropsychiatric disturbances). The conundrum of whether DLB and PDD represent the same or different entities is still under debate. Advanced neuroimaging techniques may represent a point of view to assess brain correlates in DLB and PDD. The study aimed at evaluating whether DLB and PDD may be labelled under the same disease entity or be considered distinctive pathologies. We compared DLB and PDD patients by assessing structural and functional brain imaging and including PD patients. Methods Patients with diagnosis of PD, PDD, DLB and a group of healthy controls for neuroimaging comparisons were recruited and changes in structural and resting-state functional MR (Regional Homogeneity, ReHo) were studied. Results No significant atrophy in VBM analysis was evident in PD. Conversely, PDD showed a significant bilateral frontal atrophy, whereas DLB was characterized by a predominant parietal, occipital atrophy; a similar involvement of subcortical regions in PDD and DLB was observed. ReHo demonstrated reduced local coherence of frontal regions in PD and in PDD, whereas DLB patients presented a reduced local connectivity in posterior regions. Conclusion Different brain areas are specifically involved in PDD and DLB. In the former group, greater atrophy of frontal regions with concomitant functional connectivity impairment was evident; conversely, structural and functional damage in the posterior regions characterized DLB. Despite an overlapping clinical spectrum, DLB and PDD have different networks involved and different underlying pathogenic pathways.

Neuropsychiatric And Cognitive Changes In Parkinson S Disease And Related Movement Disorders

Author: Dag Aarsland
Publisher: Cambridge University Press
ISBN: 1107039223
Size: 24.45 MB
Format: PDF, Docs
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Psychiatric and cognitive changes are common in patients with Parkinson's disease and have key clinical consequences but, despite this, these symptoms are often under-diagnosed and under-treated, leading to increased morbidity and costs. With chapters focused on the major neuropsychiatric features, Neuropsychiatric and Cognitive Changes in Parkinson's Disease and Related Movement Disorders rectifies this deficit. Written by experts in the field, with a consistent focus on relevant clinical knowledge, it provides a comprehensive overview including all the major behavioral changes associated with movement disorders. The book provides broad, in-depth, accurate and up-to-date scientific information as well as crucial understanding and practical tools to help patients. The book is essential reading for clinicians working in neurology, psychiatry and geriatric medicine.

Dementia In Clinical Practice

Author: Panteleimon Giannakopoulos
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805590156
Size: 13.56 MB
Format: PDF, ePub, Mobi
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This publication summarizes the most recent advances in neurobiology, diagnostic approaches and therapeutics of the major dementing illnesses such as Alzheimer's disease, frontotemporal dementia, Lewy body disease, and vascular dementia. In a succinct, practical and comprehensive manner, it provides an updated view of the disorders likely to be encountered in a daily practice. Each section is focused on a major form of dementia and is organized following the same scheme reviewing the pathophysiology of the disease, its diagnostic challenges, its characteristic neuroimaging features, therapeutic interventions and patient management issues. Avoiding an overspecialized approach, the book bridges the gap between clinical practice, advanced imaging, recent therapeutics and basic sciences. Thus, it serves as an excellent guide for mental health professionals working in the field of dementia as well as primary care physicians and students.