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Design And Analysis Of Dna Microarray Investigations

Author: Richard M. Simon
Publisher: Springer Science & Business Media
ISBN: 0387218661
Size: 70.78 MB
Format: PDF
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The analysis of gene expression profile data from DNA micorarray studies are discussed in this book. It provides a review of available methods and presents it in a manner that is intelligible to biologists. It offers an understanding of the design and analysis of experiments utilizing microarrays to benefit scientists. It includes an Appendix tutorial on the use of BRB-ArrayTools and step by step analyses of several major datasets using this software which is available from the National Cancer Institute.

Proteomic Profiling And Analytical Chemistry

Author: Pawel Ciborowski
Publisher: Elsevier
ISBN: 0444636900
Size: 45.85 MB
Format: PDF, ePub, Mobi
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Proteomic Profiling and Analytical Chemistry: The Crossroads, Second Edition helps scientists without a strong background in analytical chemistry to understand principles of the multistep proteomic experiment necessary for its successful completion. It also helps researchers who do have an analytical chemistry background to break into the proteomics field. Highlighting points of junction between proteomics and analytical chemistry, this resource links experimental design with analytical measurements, data analysis, and quality control. This targeted point of view will help both biologists and chemists to better understand all components of a complex proteomic study. The book provides detailed coverage of experimental aspects such as sample preparation, protein extraction and precipitation, gel electrophoresis, microarrays, dynamics of fluorescent dyes, and more. The key feature of this book is a direct link between multistep proteomic strategy and quality control routinely applied in analytical chemistry. This second edition features a new chapter on SWATH-MS, substantial updates to all chapters, including proteomic database search and analytical quantification, expanded discussion of post-hoc statistical tests, and additional content on validation in proteomics. Covers the analytical consequences of protein and peptide modifications that may have a profound effect on how and what researchers actually measure Includes practical examples illustrating the importance of problems in quantitation and validation of biomarkers Helps in designing and executing proteomic experiments with sound analytics

Analyzing Ecological Data

Author: Alain Zuur
Publisher: Springer Science & Business Media
ISBN: 0387459723
Size: 37.90 MB
Format: PDF
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This book provides a practical introduction to analyzing ecological data using real data sets. The first part gives a largely non-mathematical introduction to data exploration, univariate methods (including GAM and mixed modeling techniques), multivariate analysis, time series analysis, and spatial statistics. The second part provides 17 case studies. The case studies include topics ranging from terrestrial ecology to marine biology and can be used as a template for a reader’s own data analysis. Data from all case studies are available from www.highstat.com. Guidance on software is provided in the book.

Fundamentals Of Food Biotechnology

Author: Byong H. Lee
Publisher: John Wiley & Sons
ISBN: 1118384911
Size: 28.23 MB
Format: PDF, Mobi
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Food biotechnology is the application of modern biotechnological techniques to the manufacture and processing of food, for example through fermentation of food (which is the oldest biotechnological process) and food additives, as well as plant and animal cell cultures. New developments in fermentation and enzyme technological processes, molecular thermodynamics, genetic engineering, protein engineering, metabolic engineering, bioengineering, and processes involving monoclonal antibodies, nanobiotechnology and quorum sensing have introduced exciting new dimensions to food biotechnology, a burgeoning field that transcends many scientific disciplines. Fundamentals of Food Biotechnology, 2nd edition is based on the author’s 25 years of experience teaching on a food biotechnology course at McGill University in Canada. The book will appeal to professional food scientists as well as graduate and advanced undergraduate students by addressing the latest exciting food biotechnology research in areas such as genetically modified foods (GMOs), bioenergy, bioplastics, functional foods/nutraceuticals, nanobiotechnology, quorum sensing and quenching. In addition, cloning techniques for bacterial and yeast enzymes are included in a “New Trends and Tools” section and selected references, questions and answers appear at the end of each chapter. This new edition has been comprehensively rewritten and restructured to reflect the new technologies, products and trends that have emerged since the original book. Many new aspects highlight the short and longer term commercial potential of food biotechnology.

All Of Statistics

Author: Larry Wasserman
Publisher: Springer Science & Business Media
ISBN: 0387217363
Size: 69.96 MB
Format: PDF, Docs
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Taken literally, the title "All of Statistics" is an exaggeration. But in spirit, the title is apt, as the book does cover a much broader range of topics than a typical introductory book on mathematical statistics. This book is for people who want to learn probability and statistics quickly. It is suitable for graduate or advanced undergraduate students in computer science, mathematics, statistics, and related disciplines. The book includes modern topics like non-parametric curve estimation, bootstrapping, and classification, topics that are usually relegated to follow-up courses. The reader is presumed to know calculus and a little linear algebra. No previous knowledge of probability and statistics is required. Statistics, data mining, and machine learning are all concerned with collecting and analysing data.

Handbook Of Biofunctional Surfaces

Author: Wolfgang Knoll
Publisher: CRC Press
ISBN: 9814364185
Size: 55.63 MB
Format: PDF, Docs
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The design and synthesis of molecularly or supramolecularly defined interfacial architectures have seen in recent years a remarkable growth of interest and scientific research activities for various reasons. On the one hand, it is generally believed that the construction of an interactive interface between the living world of cells, tissue, or whole organisms and the (inorganic or organic) materials world of technical devices such as implants or medical parts requires proper construction and structural (and functional) control of this organism–machine interface. It is still the very beginning of generating a better understanding of what is needed to make an organism tolerate implants, to guarantee bidirectional communication between microelectronic devices and living tissue, or to simply construct interactive biocompatibility of surfaces in general. This exhaustive book lucidly describes the design, synthesis, assembly and characterization, and bio-(medical) applications of interfacial layers on solid substrates with molecularly or supramolecularly controlled architectures. Experts in the field share their contributions that have been developed in recent years.

Biomarkers Of The Tumor Microenvironment

Author: Lars A. Akslen
Publisher: Springer
ISBN: 331939147X
Size: 36.57 MB
Format: PDF, ePub
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This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Survival Analysis

Author: David G. Kleinbaum
Publisher: Springer Science & Business Media
ISBN: 9780387239187
Size: 71.53 MB
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This greatly expanded second edition of Survival Analysis- A Self-learning Text provides a highly readable description of state-of-the-art methods of analysis of survival/event-history data. This text is suitable for researchers and statisticians working in the medical and other life sciences as well as statisticians in academia who teach introductory and second-level courses on survival analysis. The second edition continues to use the unique "lecture-book" format of the first (1996) edition with the addition of three new chapters on advanced topics: Chapter 7: Parametric Models Chapter 8: Recurrent events Chapter 9: Competing Risks. Also, the Computer Appendix has been revised to provide step-by-step instructions for using the computer packages STATA (Version 7.0), SAS (Version 8.2), and SPSS (version 11.5) to carry out the procedures presented in the main text. The original six chapters have been modified slightly to expand and clarify aspects of survival analysis in response to suggestions by students, colleagues and reviewers, and to add theoretical background, particularly regarding the formulation of the (partial) likelihood functions for proportional hazards, stratified, and extended Cox regression models David Kleinbaum is Professor of Epidemiology at the Rollins School of Public Health at Emory University, Atlanta, Georgia. Dr. Kleinbaum is internationally known for innovative textbooks and teaching on epidemiological methods, multiple linear regression, logistic regression, and survival analysis. He has provided extensive worldwide short-course training in over 150 short courses on statistical and epidemiological methods. He is also the author of ActivEpi (2002), an interactive computer-based instructional text on fundamentals of epidemiology, which has been used in a variety of educational environments including distance learning. Mitchel Klein is Research Assistant Professor with a joint appointment in the Department of Environmental and Occupational Health (EOH) and the Department of Epidemiology, also at the Rollins School of Public Health at Emory University. Dr. Klein is also co-author with Dr. Kleinbaum of the second edition of Logistic Regression- A Self-Learning Text (2002). He has regularly taught epidemiologic methods courses at Emory to graduate students in public health and in clinical medicine. He is responsible for the epidemiologic methods training of physicians enrolled in Emorya??s Master of Science in Clinical Research Program, and has collaborated with Dr. Kleinbaum both nationally and internationally in teaching several short courses on various topics in epidemiologic methods.

Analysing Ecological Data

Author: Alain F. Zuur
Publisher: Springer Science & Business Media
ISBN:
Size: 14.57 MB
Format: PDF, Kindle
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This book provides a practical introduction to analyzing ecological data using real data sets. It features 17 case studies covering topics ranging from terrestrial ecology to marine biology and can be used as a template for a reader’s own data analysis.

The Statistical Analysis Of Functional Mri Data

Author: Nicole Lazar
Publisher: Springer Science & Business Media
ISBN: 0387781919
Size: 11.13 MB
Format: PDF, ePub, Docs
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The study of brain function is one of the most fascinating pursuits of m- ern science. Functional neuroimaging is an important component of much of the current research in cognitive, clinical, and social psychology. The exci- ment of studying the brain is recognized in both the popular press and the scienti?c community. In the pages of mainstream publications, including The New York Times and Wired, readers can learn about cutting-edge research into topics such as understanding how customers react to products and - vertisements (“If your brain has a ‘buy button,’ what pushes it?”, The New York Times,October19,2004),howviewersrespondtocampaignads(“Using M. R. I. ’s to see politics on the brain,” The New York Times, April 20, 2004; “This is your brain on Hillary: Political neuroscience hits new low,” Wired, November 12,2007),howmen and womenreactto sexualstimulation (“Brain scans arouse researchers,”Wired, April 19, 2004), distinguishing lies from the truth (“Duped,” The New Yorker, July 2, 2007; “Woman convicted of child abuse hopes fMRI can prove her innocence,” Wired, November 5, 2007), and even what separates “cool” people from “nerds” (“If you secretly like Michael Bolton, we’ll know,” Wired, October 2004). Reports on pathologies such as autism, in which neuroimaging plays a large role, are also common (for - stance, a Time magazine cover story from May 6, 2002, entitled “Inside the world of autism”).