Download drug biomembrane interaction studies the application of calorimetric techniques woodhead publishing series in biomedicine in pdf or read drug biomembrane interaction studies the application of calorimetric techniques woodhead publishing series in biomedicine in pdf online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get drug biomembrane interaction studies the application of calorimetric techniques woodhead publishing series in biomedicine in pdf book now. This site is like a library, Use search box in the widget to get ebook that you want.



Drug Biomembrane Interaction Studies

Author: Rosario Pignatello
Publisher: Elsevier
ISBN: 1908818344
Size: 14.97 MB
Format: PDF, Docs
View: 348
Download and Read
The design and development of drugs and new pharmaceutical formulations require a full characterization of the chemical and physicochemical events occurring at the level of the single active ingredients or excipients, as well as their reciprocal interaction. Thermal analysis techniques are among the most widely used methods to achieve this; among them, the Differential Scanning Calorimetry (DSC) technique, in which the thermotropic behaviour of a single substance or mixtures is analyzed as a function of a controlled temperature program. DSC is an accurate and rapid thermo-analytical technique, widely used by the pharmaceutical industry and in drug research to investigate several physico-chemical phenomena, such as polymorphism, melting and crystallization, purity, and drug-excipient interaction; as well as characterizing biomolecules such as genetic material. Drug-biomembrane interaction studies is written by scientists renowned for their work in the field of DSC applications to drug development and delivery, and especially to drug-biomembrane interaction studies. The book combines insights from biochemistry and physiology with those from structural biology, nanotechnology and biothermodynamics, to obtain a complete depiction of cell membranes and their functions. Summarizes and updates the recent development in a unique handbook format Consists of a combination of scientific updates within the field Contains chapters written by some of the highest-level experts in the field of DSC

Nanoparticulate Drug Delivery

Author: Vandana Patravale
Publisher: Elsevier
ISBN: 1908818190
Size: 75.86 MB
Format: PDF, ePub, Docs
View: 1646
Download and Read
Nanotechnology-based therapeutics, operating at scales of billionths of a metre, have great potential for future expansion in altering the scale and methods of drug delivery. The availability of these novel formulations to once-inaccessible areas of the body has greatly expanded the therapeutic window of existing drug molecules. Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems from the laboratory into a commercially viable sector. The first chapters of the book provide an overview of the use and characterization of nanoparticulate systems as drug carriers, including the assessment of their morphology, sterility and potential toxicity. In the latter part of the book, chapters cover nanotoxicology, regulatory aspect and clinical trials, ending with an overview of several case studies and a look towards future developments. Discusses the issues surrounding nanoparticulate products, based on personal experience of their formulation Provides an overview of new application areas, including RNA interference Outlines the pros and cons of nanoparticulate products, and discusses how these may influence their route into the commercial sector

Ocular Transporters And Receptors

Author: Ashim K Mitra
Publisher: Elsevier
ISBN: 190881831X
Size: 55.45 MB
Format: PDF, ePub, Docs
View: 2578
Download and Read
Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Lean Biomanufacturing

Author: Nigel J Smart
Publisher: Elsevier
ISBN: 1908818409
Size: 72.76 MB
Format: PDF, ePub, Docs
View: 7339
Download and Read
With decreasing profit margins, increasing cost pressures, growing regulatory compliance concerns, mounting pressure from generic drugs and increasing anxiety about the future of healthcare reimbursement, pharmaceutical manufacturers are now forced to re-examine and re-assess the way they have been doing things. In order to sustain profitability, these companies are looking to reduce waste (of all kinds), improve efficiency and increase productivity. Many of them are taking a closer look at lean manufacturing as a way to achieve these goals. Lean biomanufacturing re-visits lean principles and then applies them sympathetically - in a highly practical approach - to the specific needs of pharmaceutical processes, which present significantly different challenges to more mainstream manufacturing processes. A major goal of the book is to highlight those problems and issues that appear more specific or unique to biopharmaceutical manufacturing situations and to provide some insights into what challenges are the important ones to solve and what techniques, tools and mechanisms to employ to be successful. Following an introduction to lean biomanufacturing, the book goes on to discuss lean technologies and methods applied in biomanufacturing. Later chapters cover the creation and implementation of the Transition Plan, issues facing the biopharmaceutical industry, creating a lean approach towards biopharmaceutical processes and the contribution of simulation models in developing these processes. The final chapter covers examples of new technology innovations which help facilitate lean biomanufacturing. A focus on the issues associated with the application of lean principles to biomanufacturing Practical examples of factors which can affect biopharmaceutical processes Coverage of key factors which require integration to run an efficient biopharmaceutical process

Nmr Metabolomics In Cancer Research

Author: Miroslava Čuperlović-Culf
Publisher: Elsevier
ISBN: 1908818263
Size: 73.33 MB
Format: PDF, ePub, Docs
View: 6579
Download and Read
The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

Drug Biomembrane Interaction Studies

Author: A. Fortunato
Publisher: Elsevier Inc. Chapters
ISBN: 0128091800
Size: 57.35 MB
Format: PDF, Docs
View: 1628
Download and Read
In DSC, the heat flow in and out of a sample and a reference material is measured as a function of temperature as the sample is heated, cooled, or held isothermally at constant temperature. The measurement signal is the energy absorbed or released by the sample in milliwatts. DSC can detect endothermic and exothermic effects, determine peak areas (transition and reaction enthalpies), determine temperatures that characterize a peak or other effects, and measure specific heat capacity. Since the end of the nineteenth century, DSC has been improved and optimized. With the numerous technological innovations, in both hardware and software, it can explore new and demanding applications. Different measurement principles, sensors, signal processing, accessories, and evaluation capabilities make differential scanning calorimetry one of the most common and versatile techniques in material characterization. Today DSC benefits from technological solutions used previously for other applications (MEMS technology, optical devices, and parameter estimation methods).

Drug Biomembrane Interaction Studies

Author: A. Wiśniewska-Becker
Publisher: Elsevier Inc. Chapters
ISBN: 0128091770
Size: 39.89 MB
Format: PDF, ePub, Mobi
View: 7303
Download and Read
Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical techniques are used with these models to study membrane properties and their changes under different environmental factors. This chapter describes common membrane models and some of their applications. There are two groups of models: vesicular models (micelles, bicelles and liposomes) and planar ones (lipid monolayers, supported lipid bilayers, black lipid membranes). The advantages and disadvantages of both types are discussed as well as their usefulness for particular biophysical techniques.

Membrane Spectroscopy

Author: E. Grell
Publisher: Springer Science & Business Media
ISBN: 3642815375
Size: 53.34 MB
Format: PDF, Docs
View: 4071
Download and Read
The last 10 years have seen an enormous growth in our understanding of the molecular organisation of biological membranes. Experimental methods have been devised to meas ure the translational and rotational mobility of lipids and proteins, thereby furnishing a quantitative basis for the concept of membrane fluidity. Likewise, the asymmetry of bi layer membranes as evidenced by the asymmetric insertion of proteins and lipids has been put on firm experimental ground. At higher molecular resolution it has been possible to provide a detailed pi2ture of the molecular conformation and dynamics of lipids and, to some extent, even of small peptides embedded in a bilayer matrix. Many of these achieve ments would not have been possible without the application of modem spectroscopic methods. Since these techniques are scattered in a variety of specialized textbooks the present monograph attempts to describe the key spectroscopic methods employed in present-day membrane research at an intermediate level. There is no question that the elusive detailed structure of the biological membrane demands a multiplicity of experi mental approaches and that no single spectroscopic method can cover the full range of physical phenomena encountered in a membrane. Much confusion in the literature has arisen by undue generalizations without considering the frequency range or other limi tations of the methods employed. It is to be hoped that the present monograph with its comprehensive description of most modem spectroscopic techniques, will contribute to- .

Cellulose Reinforced Nanofibre Composites

Author: Mohammad Jawaid
Publisher: Woodhead Publishing
ISBN: 0081009658
Size: 32.93 MB
Format: PDF, ePub, Docs
View: 3282
Download and Read
Cellulose-Reinforced Nanofibre Composites: Production, Properties and Applications presents recent developments in, and applications of, nanocellulose as reinforcement in composite and nanocomposite materials. Written by leading experts, the book covers properties and applications of nanocellulose, including the production of nanocellulose from different biomass resources, the usefulness of nanocellulose as a reinforcement for polymer and paper, and major challenges for successful scale-up production in the future. The chapters draw on cutting-edge research on the use of nanosized cellulose reinforcements in polymer composites that result in advanced material characteristics and significant enhancements in physical, mechanical and thermal properties. The book presents an up-to-date review of the major innovations in the field of nanocellulose and provides a reference material for future research in biomass based composite materials, which is timely due to the sustainable, recyclable and eco-friendly demand for highly innovative materials made from biomass. This book is an ideal source of information for scientific and industrial researchers working in materials science. Gathers together a broad spectrum of research on nanocellulose, with emphasis on the outstanding reinforcing potential when nanocellulose is included into a polymer matrix or as an additive to paper Demonstrates systematic approaches and investigations from processing, design, characterization and applications of nanocellulose Presents a useful reference and technical guide for nanocomposite materials R&D sectors, university academics and postgraduate students (Masters and PhD) and industrialists working in material commercialization

Improving The Safety Of Fresh Meat

Author: J Sofos
Publisher: Elsevier
ISBN: 1845691024
Size: 43.40 MB
Format: PDF, Docs
View: 6456
Download and Read
The safety of fresh meat continues to be a major concern for consumers. As a result, there has been a wealth of research on identifying and controlling hazards at all stages in the supply chain. Improving the safety of fresh meat reviews this research and its implications for the meat industry. Part one discusses identifying and managing hazards on the farm. There are chapters on the prevalence and detection of pathogens, chemical and other contaminants. A number of chapters discuss ways of controlling such hazards in the farm environment. The second part of the book reviews the identification and control of hazards during and after slaughter. There are chapters both on contamination risks and how they can best be managed. The range of decontamination techniques available to meat processors as well as such areas as packaging and storage are examined. With its distinguished editor and international team of contributors, Improving the safety of fresh meat is a standard reference for the meat industry. Learn how to identify and control hazards at all stages in the supply chain An authoritative reference on reducing microbial and other hazards in raw and fresh red meat Understand the necessity for effective intervention at each production process