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Dynamics Of Cancer

Author: Dominik Wodarz
Publisher: World Scientific
ISBN: 9814566381
Size: 57.25 MB
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The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells. Contents:Teaching GuideCancer and Somatic EvolutionMathematical Modeling of TumorigenesisBasic Growth Dynamics and Deterministic Models:Single Species GrowthTwo-Species Competition DynamicsCompetition Between Genetically Stable and Unstable CellsChromosomal Instability and Tumor GrowthAngiogenesis Inhibitors, Promoters, and Spatial GrowthEvolutionary Dynamics and Stochastic Models:Evolutionary Dynamics of Tumor Initiation Through Oncogenes: The Gain-of-Function ModelEvolutionary Dynamics of Tumor Initiation Through Tumor-Suppressor Genes: The Loss-of-Function Model and Stochastic TunnelingMicrosatellite and Chromosomal Instability in Sporadic and Familial Colorectal CancersEvolutionary Dynamics in Hierarchical PopulationsSpatial Evolutionary Dynamics of Tumor InitiationComplex Tumor Dynamics in SpaceStochastic Modeling of Cellular Growth, Treatment, and Resistance GenerationEvolutionary Dynamics of Drug Resistance in Chronic Myeloid LeukemiaAdvanced Topics:Evolutionary Dynamics of Stem-Cell Driven Tumor GrowthTumor Growth Kinetics and Disease ProgressionEpigenetic Changes and the Rate of DNA MethylationTelomeres and Cancer ProtectionGene Therapy and Oncolytic Virus TherapyImmune Responses, Tumor Growth, and TherapiesTowards Higher Complexities: Social Interactions Readership: Researchers in mathematical biology, mathematical modeling, biology, mathematical oncology. Keywords:Mathematical Oncology;Dynamics;Evolution;Evolutionary Dynamics;Cancer;Mathematical Models;Somatic Evolution;TeachingKey Features:Both a reference book for the topic, and provides material for undergraduate and graduate coursesTries to bridge the divide between mathematicians and biologists, which is also reflected in the backgrounds of the two authorsShows how mathematical concepts can be translated into experimentally and clinically useful insightsRooted in evolutionary biology, the book handles this very complex phenomenon in an intuitive and mathematically elegant wayContains problems and research projects for each topic10 pages of figures in color

A Guide To Outcome Modeling In Radiotherapy And Oncology

Author: Issam El Naqa
Publisher: CRC Press
ISBN: 0429840349
Size: 78.71 MB
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This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches. This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications. Features: Covers top-down approaches applying statistical, machine learning, and big data analytics and bottom-up approaches using first principles and multi-scale techniques, including numerical simulations based on Monte Carlo and automata techniques Provides an overview of the available software tools and resources for outcome model development and evaluation, and includes hands-on detailed examples throughout Presents a diverse selection of the common applications of outcome modeling in a wide variety of areas: treatment planning in radiotherapy, chemotherapy and immunotherapy, utility-based and biomarker applications, particle therapy modeling, oncological surgery, and the design of adaptive and SMART clinical trials

Cellular Automata

Author: Giancarlo Mauri
Publisher: Springer
ISBN: 3319998137
Size: 52.60 MB
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This book constitutes the proceedings of the 13th International Conference on Cellular Automata for Research and Industry, ACRI 2018, held in Como, Italy, in September 2018. The 47 full papers presented in this volume were carefully reviewed and selected from 64 submissions. This volume contains invited contributions and accepted papers from the main track and from the three organized workshops. The volume is organized in the following topics: biological systems modeling; simulation and other applications of CA; multi-agent systems; pedestrian and traffic dynamics; synchronization and control; theory and cryptography; asynchronous cellular automata; and crowds, traffic and cellular automata.

Integrated Population Biology And Modeling

Publisher: Elsevier
ISBN: 0444640738
Size: 58.21 MB
Format: PDF, Docs
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Integrated Population Biology and Modeling: Part A offers very complex and precise realities of quantifying modern and traditional methods of understanding populations and population dynamics. Chapters cover emerging topics of note, including Longevity dynamics, Modeling human-environment interactions, Survival Probabilities from 5-Year Cumulative Life Table Survival Ratios (Tx+5/Tx): Some Innovative Methodological Investigations, Cell migration Models, Evolutionary Dynamics of Cancer Cells, an Integrated approach for modeling of coastal lagoons: A case for Chilka Lake, India, Population and metapopulation dynamics, Mortality analysis: measures and models, Stationary Population Models, Are there biological and social limits to human longevity?, Probability models in biology, Stochastic Models in Population Biology, and more. Covers emerging topics of note in the subject matter Presents chapters on Longevity dynamics, Modeling human-environment interactions, Survival Probabilities from 5-Year Cumulative Life Table Survival Ratios (Tx+5/Tx), and more

Parallel Processing And Applied Mathematics

Author: Roman Wyrzykowski
Publisher: Springer
ISBN: 3319780247
Size: 34.85 MB
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The two-volume set LNCS 10777 and 10778 constitutes revised selected papers from the 12th International Conference on Parallel Processing and Applied Mathematics, PPAM 2017, held in Lublin, Poland, in September 2017. The 49 regular papers presented in this volume were selected from 98 submissions. For the workshops and special sessions, that were held as integral parts of the PPAM 2017 conference, a total of 51 papers was accepted from 75 submissions. The papers were organized in topical sections named as follows: Part I: numerical algorithms and parallel scientific computing; particle methods in simulations; task-based paradigm of parallel computing; GPU computing; parallel non-numerical algorithms; performance evaluation of parallel algorithms and applications; environments and frameworks for parallel/distributed/cloud computing; applications of parallel computing; soft computing with applications; and special session on parallel matrix factorizations. Part II: workshop on models, algorithms and methodologies for hybrid parallelism in new HPC systems; workshop power and energy aspects of computations (PEAC 2017); workshop on scheduling for parallel computing (SPC 2017); workshop on language-based parallel programming models (WLPP 2017); workshop on PGAS programming; minisymposium on HPC applications in physical sciences; minisymposium on high performance computing interval methods; workshop on complex collective systems.

Platons Timaios Kritias Gesetze X

Author: Plato
Publisher: Wentworth Press
ISBN: 9780274071494
Size: 18.14 MB
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This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Programmformeln Und Praxisformen Von Soziokultur

Author: Tobias J. Knoblich
Publisher: Springer-Verlag
ISBN: 365819622X
Size: 61.94 MB
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Tobias J. Knoblich gibt erstmals einen umfassenden diskurskritischen Überblick über die Soziokultur als Schlüsselbegriff der Neuen Kulturpolitik, welche die Debatten der letzten Jahrzehnte prägte und zugleich für einen neuen Typus kultureller Institutionen steht. Der Autor deckt mit der Analyse zentraler Debatten und Praxisfelder der Soziokultur die enge Verbindung mit Fragen der Demokratieentwicklung auf und fragt nach heutigen Entwicklungsproblemen. Damit legt er zugleich eine Kulturpolitikgeschichte vor, die die Perspektive ‚von unten‘ aufmacht und die Entstehung einer kulturellen Zivilgesellschaft nachzeichnet.

Die Verdammten Der Stadt

Author: Loïc Wacquant
Publisher: Springer-Verlag
ISBN: 3658026804
Size: 33.62 MB
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Die Verdammten der Stadt führt uns mitten ins schwarze Ghetto im Inneren Chicagos und in die sich deindustrialisierende Banlieue in den Außenzonen von Paris und entdeckt, dass städtische Marginalität nicht überall gleich ist. Auf Grundlage von Feld-, statistischen und historischen Daten zeigt Wacquant, dass die Rückbildung der innerstädtischen Gebiete in den Vereinigten Staaten im Anschluss an die 1960er Jahre nicht durch die Entstehung einer underclass erklärt werden kann, sondern durch den gemeinsamen Rückzug von Markt und Staat, der von einer staatlichen Politik der Rassentrennung und der Aufgabe der Städte gefördert wurde. In den europäischen Städten dagegen läutet die Ausbreitung von „Problemquartieren“ nicht die Entstehung von Ghettos amerikanischen Stils ein. Sie rührt vielmehr von der Zersetzung der Arbeiterklassegebiete, von Massenarbeitslosigkeit, der Prekarisierung von Beschäftigung und der ethnischen Durchmischung von bislang getrennten Populationen, wodurch städtische Formationen hervorgebracht wurden, die eher „Anti-Ghettos“ sind. Der Vergleich zwischen dem US-amerikanischen „Schwarzen Gürtel“ und dem „Roten Gürtel“ Frankreichs zeigt, dass staatliche Strukturen und Politiken eine entscheidende Rolle bei der Artikulation von Klasse, Rasse und Raum auf beiden Seiten des Atlantiks spielen. Er zeigt auch die Kristallisation eines neuen Regimes von Marginalität, die von der Fragmentierung der Erwerbsarbeit, dem Rückzug des Sozialstaates und der Konzentration benachteiligter sozialer Kategorien in stigmatisierten Distrikten angeheizt wird, die über kein kollektives Idiom der Identität verfügen. Diese diffamierten Bezirke sind nicht nur die Senkgruben einer vergangenen ökonomischen Ära, sondern auch die Brutstädte des Prekariats im Zeitalter des neoliberalen Kapitalismus.

Angewandte Statistik

Author: Lothar Sachs
Publisher: Springer-Verlag
ISBN: 3662057476
Size: 67.28 MB
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Auch die 7., völlig neu bearbeitete Auflage dient zum Lernen, Anwenden und Nachschlagen. Da statistische Programmpakete weit verbreitet sind, hat man sich in dieser Auflage mehr auf die Planung von Untersuchungen konzentriert. Darüber hinaus wurden zahlreiche Gebiete ausführlicher behandelt (z.B. Kombinatorik) und neue Methoden wie der Jonckheer-Test neu aufgenommen. Zahlreiche aktualisierte Zusammenhänge und Verweise sowie viele neue Übersichten, Tabellen und Beispiele runden dieses Buch ab.