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Emperor Of Enzymes

Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 9814699837
Size: 30.60 MB
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This book chronicles the life and work of the late Arthur Kornberg, one of the premier biochemists in the world, who discovered the enzyme DNA polymerase, a key enzyme required for the biosynthesis of DNA. The book provides readers with a view of the personality and character of one of the great biochemists of the late 20th century, as well as insights into the origin and growth of the discipline of nucleic acid biochemistry, especially the biosynthesis of DNA. The book consists of 17 chapters that trace the life and work of Arthur Kornberg. Contents:Growing Up in New York City, Medical School and the United States NavyLearning from the Masters — The NIH and the Ochoa LaboratoryThe Cori Laboratory — And a Return to the NIHWashington UniversityThe Lure of Nucleic Acid EnzymologyThe Discovery of DNA PolymeraseStanford University Medical SchoolThe Stanford Department of BiochemistryLife in the Test Tube?Like Father Like SonsSpores — A Brief InterludeDNA Replication — The Holy GrailPolyphosphateA Life of WritingIn Support of Basic ScienceCommercial Ventures and the Founding of DNAXA Life Well Lived Readership: General public, students and researchers in biochemistry and enzymology.

I Am The Smartest Man I Know

Author: Ivar Giaever
Publisher: World Scientific
ISBN: 9813109203
Size: 50.87 MB
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'" A unique individual with a fascinating life story, Ivar Giaever is a scientist who won the Nobel Prize in Experimental Physics in 1973. In his own words, Giaever relates an absorbing tale of how important luck and good fortune have been in shaping his life. He narrates the story of an ordinary childhood in Norway and an unremarkable undergraduate career at university. After finishing his engineering degree, he served in the Norwegian army and married his childhood sweetheart, Inger Skramstad. His desire to make a better life for his new family led Ivar to Canada and then to the United States. Even without an advanced degree in a scientific field, Ivar was given the opportunity to work with cutting-edge scientific researchers at General Electric R&D in Schenectady, New York. While there, he completed his PhD at Rensselaer Polytechnic Institute — one of the United States'' oldest technological universities. His work on superconductivity led to worldwide recognition and the Nobel Prize. This memoire is more than the story of an accomplished, world-renowned scientist: it is an engaging reminiscence of an independent, highly creative thinker and problem solver who loves games and puzzles, skiing and windsurfing, and time with friends and family. Dr Ivar Giaever''s fascinating story intertwines his views on the nature of science, scientific processes, contemporary issues such as global warming, and the great benefits the Nobel Prize has afforded him. Written with humor and often tongue-in-cheek, "I am the Smartest Man I know" is one man''s meditation on science, intellectual inquiry, and life itself. Readership: Students and the general public interested in science and entrepreneurship. "'

The Emperor Of All Maladies

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 1439170916
Size: 16.29 MB
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An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the development of present-day treatments. Reprint. Best-selling winner of the Pulitzer Prize. Includes reading-group guide.

In Search Of Memory The Emergence Of A New Science Of Mind

Author: Eric R. Kandel
Publisher: W. W. Norton & Company
ISBN: 9780393070514
Size: 73.76 MB
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“A stunning book.”—Oliver Sacks Memory binds our mental life together. We are who we are in large part because of what we learn and remember. But how does the brain create memories? Nobel Prize winner Eric R. Kandel intertwines the intellectual history of the powerful new science of the mind—a combination of cognitive psychology, neuroscience, and molecular biology—with his own personal quest to understand memory. A deft mixture of memoir and history, modern biology and behavior, In Search of Memory brings readers from Kandel's childhood in Nazi-occupied Vienna to the forefront of one of the great scientific endeavors of the twentieth century: the search for the biological basis of memory.

Laughing Gas Viagra And Lipitor

Author: Jie Jack Li
Publisher: Oxford University Press
ISBN: 0195300998
Size: 26.61 MB
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This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated with them.

A Biography Of Paul Berg

Author: Errol C. Friedberg
Publisher: World Scientific Publishing Company Incorporated
ISBN: 9789814569040
Size: 78.16 MB
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This biography details the life of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's life from birth, in 1926, to the present, with special emphasis on his enormous scientific contributions, including being the first to develop technology that led to gene cloning science. In 1980, Berg received a Nobel Prize in chemistry for this work. In addition to his contributions in the research laboratory, Berg orchestrated and oversaw a historic meeting at Asilomar, California that centered on a threatening controversy surrounding the perception by some of the harmful potential of recombinant DNA technology. This meeting did much to forestall this controversy and to put in place the regulation of recombinant DNA work, thus putting fears to rest. The recombinant DNA controversy was a historic outcome of the discovery of gene cloning. Notably, it represented a paramount example of scientific foresight and due diligence by the scientific community, rather than by regulatory entities in the United States and many other countries. The ultimate acceptance of gene/DNA cloning led to a new era of modern biology that thrives to the present. This book is aimed primarily at scientists and those in training. The book strives to simply provide information for the general reader, but is not specifically tailored for a general reading audience. While many books cover the recombinant DNA controversy, none have satisfactorily addressed this historic period and are often contradictory about the many who's, where's, and why's involved. Additionally, the great majority of these were written by non-scientists. This biography of Paul Berg provides access to numerous archived letters and documents at Stanford University not previously addressed, and to the chronology of events as recalled and documented by him, as well as other key personalities, many of whom were interviewed.

Nobel Prize Women In Science

Author: Sharon Bertsch McGrayne
Publisher: Joseph Henry Press
ISBN: 0309072700
Size: 15.41 MB
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Since 1901 there have been over three hundred recipients of the Nobel Prize in the sciences. Only ten of them -- about 3 percent -- have been women. Why? In this updated version of Nobel Prize Women in Science, Sharon Bertsch McGrayne explores the reasons for this astonishing disparity by examining the lives and achievements of fifteen women scientists who either won a Nobel Prize or played a crucial role in a Nobel Prize - winning project. The book reveals the relentless discrimination these women faced both as students and as researchers. Their success was due to the fact that they were passionately in love with science. The book begins with Marie Curie, the first woman to win the Nobel Prize in physics. Readers are then introduced to Christiane Nusslein-Volhard, Emmy Noether, Lise Meitner, Barbara McClintock, Chien-Shiung Wu, and Rosalind Franklin. These and other remarkable women portrayed here struggled against gender discrimination, raised families, and became political and religious leaders. They were mountain climbers, musicians, seamstresses, and gourmet cooks. Above all, they were strong, joyful women in love with discovery. Nobel Prize Women in Science is a startling and revealing look into the history of science and the critical and inspiring role that women have played in the drama of scientific progress.

Science And Its Times 700 1449

Author: Neil Schlager
Publisher: Gale / Cengage Learning
ISBN: 9780787639341
Size: 13.23 MB
Format: PDF
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Combining essays on people, theories, discoveries and concepts with overviews, primary documents and chronological elements, this reference offers a way to understand the impact of science on the course of human history and how science affects everyday life.

A Biography Of Paul Berg

Author: Errol C Friedberg
Publisher: World Scientific
ISBN: 9814569062
Size: 25.41 MB
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With a Foreword writer Sydney Brenner (Nobel laureate in Physiology or Medicine, 2002) This biography details the life of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's life from birth, in 1926, to the present, with special emphasis on his enormous scientific contributions, including being the first to develop technology that led to gene cloning science. In 1980, Berg received a Nobel Prize in chemistry for this work. In addition to his contributions in the research laboratory, Berg orchestrated and oversaw a historic meeting at Asilomar, California that centered on a threatening controversy surrounding the perception by some of the harmful potential of recombinant DNA technology. This meeting did much to forestall this controversy and to put in place the regulation of recombinant DNA work, thus putting fears to rest. The recombinant DNA controversy was a historic outcome of the discovery of gene cloning. Notably, it represented a paramount example of scientific foresight and due diligence by the scientific community, rather than by regulatory entities in the United States and many other countries. The ultimate acceptance of gene/DNA cloning led to a new era of modern biology that thrives to the present. This book is aimed primarily at scientists and those in training. The book strives to simply provide information for the general reader, but is not specifically tailored for a general reading audience. While many books cover the recombinant DNA controversy, none have satisfactorily addressed this historic period and are often contradictory about the many who's, where's, and why's involved. Additionally, the great majority of these were written by non-scientists. This biography of Paul Berg provides access to numerous archived letters and documents at Stanford University not previously addressed, and to the chronology of events as recalled and documented by him, as well as other key personalities, many of whom were interviewed. Contents:Part I:Growing Up in BrooklynThe Essential Paul BergCollege — and World War IIWestern Reserve UniversityCopenhagenPart II:Washington University, St. LouisDiscovering Transfer RNAStanford University — and Its Refurbished Department of BiochemistryTranscription and Translation: New DirectionsPart III:Making Recombinant DNA — The First Faltering StepsMaking Recombinant DNA — A Major BreakthroughEcoRI Restriction Endonuclease — A Major Breakthrough“Coincidence is the Word We Use When We Can't See the Levers and Pulleys”Yet Another Stanford ContributionPart IV:An Historic Meeting in HawaiiThe Recombinant DNA ControversyA Momentous Gordon Research ConferenceMaking Recombinant Molecules with Frog DNAThe Controversy Heats UpAsilomar IIThe Dissenters: A Different Point of ViewThe AftermathLegislative and Revisionist Challenges to Recombinant DNAAsilomar II — Lessons LearnedPart V:The Nobel Prize in ChemistryCommercializing the TechnologyLife Goes onThe “Retirement” YearsPublic Policy Issues — and Other InterestsPersonal Challenges Readership: Researchers, graduate students, undergraduates in life sciences, medicine and chemistry and interested lay public. Keywords:Recombinant DNA;Paul Berg;Stanford University;Errol Friedberg;DNA;tRNA;Asilomar Meeting Western Reserve University;Stanley Cohen Gene Cloning;Nobel PrizeReviews: “This is a great and very readable story of a renowned biochemist moving outside his comfort zone to provide needed leadership at a time of national turmoil. Friedberg takes us from Berg's beginnings in Brooklyn in an immigrant Yiddish-speaking family to his receipt of the Nobel Prize. He also describes Berg's guidance of a process of public acceptance of a revolutionary scientific advance — Recombinant DNA technology — that appeared to be hazardous because it was so innovative. The book reads easily, with enough technical discussion to be informative without being too demanding. It also includes an insightful investigation of the mystery of who actually deserves credit for making the technology a reality, which will fascinate other scientists and anyone who cares about the history of science and technology.” David Baltimore Nobel Laureate “Friedberg's book is a valuable addition to the literature on the scientific development of recombinant DNA technology, particularly the interactions among the numerous scientists involved who jockeyed for priority. It also details the life and times of one of the most outstanding biochemists this country has ever produced. ” DNA Repair

Correcting The Blueprint Of Life

Author: Errol C. Friedberg
Publisher: CSHL Press
ISBN: 9780879695071
Size: 66.10 MB
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A brief history of the discovery of the more important mechanisms by which cells respond to DNA damage. The study, which introduces the study of DNA mutagenesis and repair, is aimed at advanced undergraduates or graduate students, as well as researchers in a variety of fields.