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Essential Ivf

Author: Jonathan van Blerkom
Publisher: Springer Science & Business Media
ISBN: 1441989552
Size: 22.33 MB
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There is no clearer testament to the importance and efficacy of in vitro fertilization in the treatmentof the infertilepatient than the fact that over one million babies have been born since its clinical introduction in 1978. The successof this worldwideendeavorhas evolvedto treat some of the formerly most intractable forms of infertility and requires individuals with different skills and insights whose activities are often compartmentalized into clinical, laboratory and research functions. The intent of Essential lVF is to present current issues in clinical IVF that encompass the varied activities of those engaged in this enterprise. By integrating clinical, basic research and laboratory-related aspects of human reproduction, readers with diverse interests should obtain a more complete understanding of the impact, importance and inter-relatedness of each in the progress of infertility treatment, and an appreciation of whether emerging technologies will or should contribute to this progress in the near future. The topics selected for this volume include research that has begun to explain the origins of differential follicular, gamete, embryo and uterine competence, and specific laboratory procedures and protocols that may have important clinical implications forthe generation ofdevelopmentally viable embryos. Human embryoresearchoverthe past 25 years has notonly confirmed that the developmental potential of each embryo is unique, but more importantly, demonstrated how genetic and nongenetic factors for sperm and oocyte determineembryo competencewell before fertilization. Several chapters deal with the origins of normal and compromised gametes and how those with high competence can be identified and isolated for fertilization.

Practical Manual Of In Vitro Fertilization

Author: Zsolt Peter Nagy
Publisher: Springer Science & Business Media
ISBN: 1441917802
Size: 71.31 MB
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The Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is a unique, accessible title that provides a complete review of the most well-established and current diagnostic and treatment techniques comprising in vitro fertilization. Throughout the chapters, a uniform structure is employed, including a brief abstract, a keyword glossary, a step-by-step protocol of the laboratory procedures, several pages of expert commentary, key issues of clinical concern, and a list of references. The result is a readily accessible, high quality reference guide for reproductive endocrinologists, urologists, embryologists, biologists and research scientists. The Manual also offers an excellent description of novel procedures that will likely be employed in the near future. An indispensable resource for physicians and basic scientists, the Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices is an invaluable reference and addition to the literature.

Oogenesis

Author: Marie-Helene Verlhac
Publisher: John Wiley & Sons
ISBN: 9780470687987
Size: 25.90 MB
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Oogenesis - the process by which female germ cells develop into mature eggs, or ova - is a complex process involving many important elements of developmental and cellular biology: from cell-cell interactions, complex signalling cascades, specialized cell cycles and cytoskeleton organization. Oocytes from various species (including clam, starfish, xenopus and mouse) are excellent model systems to study the biochemistry of cell division with important implications for basic and clinical research. This book describes the entire process of oogenesis in chronological order with contributions from leading international researchers and chapters covering medical and ethical considerations in oogenic biology. Topics include sex determination and gonadal development, control of meiotic chromosome pairing and homologous recombination, control of meiotic divisions and the remodelling of the oocyte into a totipotent zygote as well as medically-assisted reproduction. This volume is an essential resource for all students, researchers and clinicians in developmental and reproductive biology. Key features: Reaches beyond the study of simply meiosis to cover all aspects of oogenesis Synthesizes recent advances in the field, drawing on studies from different model species Chapter sequence designed to follow the time line in vivo Written by an international panel of expert researchers

Human Genome Editing

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309452880
Size: 52.96 MB
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Genome editing is a powerful new tool for making precise alterations to an organism’s genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Handbook Of Fertility

Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0128009934
Size: 48.91 MB
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Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men. Explores how alcohol, nicotine, and other drugs of abuse disrupt and impair reproductive health Reviews studies of common conditions such as obesity and metabolic syndrome and their effect on fertility and reproductive health Investigates the components of foods and dietary supplements, in particular oxidative stress and antioxidants Presents the nutritional effects of foods and dietary supplements and their benefits and risks relating to reproductive health

Textbook Of Clinical Embryology

Author: Kevin Coward
Publisher: Cambridge University Press
ISBN: 110727625X
Size: 69.20 MB
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The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.