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Cell Biology Of Extracellular Matrix

Author: E.D. Hay
Publisher: Springer Science & Business Media
ISBN: 1461537703
Size: 74.21 MB
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In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The Extracellular Matrix An Overview

Author: Robert Mecham
Publisher: Springer Science & Business Media
ISBN: 9783642165559
Size: 44.92 MB
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Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix In Tumor Biology

Author: Rolf A. Brekken
Publisher: Springer
ISBN: 3319609076
Size: 66.93 MB
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This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Extracellular Matrix

Author: Mark A. Zern
Publisher: CRC Press
ISBN: 9780824788308
Size: 78.76 MB
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Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the major extracellular matric components, including collagens, laminin, fibronectin, and proteoglycans; delineates the mechanisms leading to increased depositions of the matrix proteins during hepatic fibrogenesis; details new therapeutic approaches to liver disease; and more.;With authoritative contributions from more than 40 leading international experts representing five countries, Extracellular Matrix should be a useful reference for all scientists interested in matrix biology, chemistry, or pathobiology, especially gastroenterologists, hepatologists, pathologists, and graduate and medical school students in these disciplines.

Extracellular Matrix Biology

Author: Richard O. Hynes
ISBN: 9781936113385
Size: 24.12 MB
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In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states. The editors are both giants in the field (Dr. Hynes discovered fibronectin), who are highly respected through the cell, molecular, and cancer biology communities.

Fibronectin In Health And Disease

Author: Steven E. Carsons
Publisher: CRC Press
ISBN: 1351088939
Size: 32.33 MB
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This timely volume highlights current knowledge concerning the role of fibronectin in human biology and medicine. It is intended to stimulate further investigation in this area. Emphasized are the importance of fibronectin in the interaction between the cell and its environment; and the role of the fibronectin in the determination of cell behavior in normal physiologic processes, in malignant behavior of cells, and in inflammatory disease. This book is valuable to those in the biomedical community interested in fibronectin, the microenvironment and extracellular matrix. It is also important to those interested in the pathobiochemistry of malignant disease and inflammatory disorders.

Methods In Extracellular Matrix Biology

Publisher: Academic Press
ISBN: 0128122986
Size: 10.66 MB
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Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM. Contains contributions from experts in the field from across the world Covers a wide array of topics on the extracellular matrix, including an understanding crucial proteins and the glycoproteins components of ECM Includes analysis based topics, such as quantification of collagen and elastin, mulit-photon analysis of ECM and ECM crosslink analysis


Author: Deane Mosher
Publisher: Elsevier
ISBN: 0323148247
Size: 39.18 MB
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Fibronectin presents the studies made on the physiological and pathophysiological roles of fibronectin. The book presents chapters that discuss the primary structure of fibronectin and its mRNA; the physicochemical properties of fibronectin and fibronectin fragments; the fibronectin-containing extracellular matrix; the relationship of fibronectin and fibronectin-containing matrix to embryogenesis, wound healing, and the biology of cancer cells; the roles of fibronectin in platelet aggregation, attachment of microorganisms, pathogenesis of kidney diseases, arthritis, and lung fibrosis; and the production of purified concentrates of fibronectin suitable for use in patients. The book will be of much interest to biologists, biochemists, pharmacologists, and medical practitioners and researchers.

Receptors For Extracellular Matrix

Author: John Mcdonald
Publisher: Academic Press
ISBN: 0323141234
Size: 24.25 MB
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Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.

Biology Of Endothelial Cells

Author: Eric A. Jaffe
Publisher: Springer Science & Business Media
ISBN: 146132825X
Size: 76.18 MB
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The participation of endothelial cells in various physiologic and pathologic processes has been hypothesized since before the turn of the century. However, until recently, direct evidence for endothelial involvement in these processes has been extremely difficult to obtain due to the inability to study endothelial cell function in vitro. Though the possibility of using cultured endothelial cells to study endothelial cell function in vitro was recognized many years ago, the inability to culture unambiguously identifiable endothelial cells limited investigators in their studies of endothelial function. As a result, the field of endothelial cell biology lay relatively fallow for many years. The development in the early 1970's of routine and easily implemented methods for culturing human endothelial cells and the demonstration that cultured endothelial cells synthesized a physiologically relevant protein, Factor VIII/von Willebrand Factor, quickly changed this state of affairs. Over the following decade the scope of endothelial cell research rapidly widened, spreading in a number of directions. First, methods were developed to culture endothelial cells from a variety of species. Second, methods were developed to culture endothelial cells from different organs and types of blood vessels (arteries, veins, and capillaries) within a single species. Third, and most important, investigators began using cultured endothelial cells as tools to study the potential involvement of endothelial cells in a wide assortment of biologically interesting processes. The net result has been a tremendous increase in our understanding of endothelial cell function.