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Fundamentals Of Modern Bioprocessing

Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1466585749
Size: 47.32 MB
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Biological drug and vaccine manufacturing has quickly become one of the highest-value fields of bioprocess engineering, and many bioprocess engineers are now finding job opportunities that have traditionally gone to chemical engineers. Fundamentals of Modern Bioprocessing addresses this growing demand. Written by experts well-established in the field, this book connects the principles and applications of bioprocessing engineering to healthcare product manufacturing and expands on areas of opportunity for qualified bioprocess engineers and students. The book is divided into two sections: the first half centers on the engineering fundamentals of bioprocessing; while the second half serves as a handbook offering advice and practical applications. Focused on the fundamental principles at the core of this discipline, this work outlines every facet of design, component selection, and regulatory concerns. It discusses the purpose of bioprocessing (to produce products suitable for human use), describes the manufacturing technologies related to bioprocessing, and explores the rapid expansion of bioprocess engineering applications relevant to health care product manufacturing. It also considers the future of bioprocessing—the use of disposable components (which is the fastest growing area in the field of bioprocessing) to replace traditional stainless steel. In addition, this text: Discusses the many types of genetically modified organisms Outlines laboratory techniques Includes the most recent developments Serves as a reference and contains an extensive bibliography Emphasizes biological manufacturing using recombinant processing, which begins with creating a genetically modified organism using recombinant techniques Fundamentals of Modern Bioprocessing outlines both the principles and applications of bioprocessing engineering related to healthcare product manufacturing. It lays out the basic concepts, definitions, methods and applications of bioprocessing. A single volume comprehensive reference developed to meet the needs of students with a bioprocessing background; it can also be used as a source for professionals in the field.

Biosimilars And Interchangeable Biologics

Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1498743501
Size: 13.45 MB
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What’s the Deal with Biosimilars? Biosimilars are gaining momentum as new protein therapeutic candidates that can help fill a vital need in the healthcare industry. The biological drugs are produced by recombinant DNA technology that allows for large-scale production and an overall reduction time in costs and development. Part of a two-volume set that covers varying aspects of biosimilars, Biosimilars and Interchangeable Biologics: Tactical Elements explores the development and manufacturing of biosimilars and targets challenges surrounding the creation of these products. This includes manufacturing, production costs, and intellectual property barriers, particularly in regulated markets (regulatory agencies are still in the process of developing guidelines). It addresses the complexity of biological drugs, and it discusses specific structural elements vital to the functionality, immunogenicity, and safety of biosimilar products. Of specific interest to practitioners, researchers, and scientists in the biopharmaceutical industry, this volume provides an overall understanding of the hurdles, difficulties, and practicalities of developing a strong plan. It introduces a step-by-step approach for creating a strategy that helps develop and manufacture a biosimilar product while reducing overall production costs and meeting the requirements of biosimilarity based on analytical and functional, pharmacokinetic, pharmacodynamic (where applicable), and nonclinical toxicology or toxicokinetic similarity (where appropriate) while remaining competitive in the market.

Bioprocess Engineering

Author: Dhinakar S. Kompala
Publisher: CRC PressI Llc
ISBN: 9780849380839
Size: 53.50 MB
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Comprehensive and modern in its approach and coverage, this textbook explains the bioprocess engineering fundamentals of reaction kinetics, reactor design, and operating strategies for the modern biotechnology process. It focuses on the three major biological catalysts, namely, enzymes, microbial cells, and mammalian cells. The author presents the three biocatalysts in parallel, to bring out their common themes and highlight their differences. He thoroughly addresses the modern biotechnology processes using recombinant microbial and mammalian cells and includes practical examples from industrial applications and end of chapter problems.

Cell Adhesion In Bioprocessing And Biotechnology

Author: Martin Hjortso
Publisher: CRC Press
ISBN: 9780824789459
Size: 17.49 MB
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Offers a detailed introduction to the fundamental phenomena that govern cell adhesion and describes bioengineering processes that employ cell adhesion, focusing on both biochemical and biomedical applications. All industrially relevant issues of cell adhesion - from basic concepts, quantitative experiments, and mathematical models to applications in bioreactors and other process equipment - are examined.

Fundamentals Of Food Biotechnology

Author: Byong H. Lee
Publisher: John Wiley & Sons
ISBN: 1118384911
Size: 14.52 MB
Format: PDF, ePub, Mobi
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Food biotechnology is the application of modern biotechnological techniques to the manufacture and processing of food, for example through fermentation of food (which is the oldest biotechnological process) and food additives, as well as plant and animal cell cultures. New developments in fermentation and enzyme technological processes, molecular thermodynamics, genetic engineering, protein engineering, metabolic engineering, bioengineering, and processes involving monoclonal antibodies, nanobiotechnology and quorum sensing have introduced exciting new dimensions to food biotechnology, a burgeoning field that transcends many scientific disciplines. Fundamentals of Food Biotechnology, 2nd edition is based on the author’s 25 years of experience teaching on a food biotechnology course at McGill University in Canada. The book will appeal to professional food scientists as well as graduate and advanced undergraduate students by addressing the latest exciting food biotechnology research in areas such as genetically modified foods (GMOs), bioenergy, bioplastics, functional foods/nutraceuticals, nanobiotechnology, quorum sensing and quenching. In addition, cloning techniques for bacterial and yeast enzymes are included in a “New Trends and Tools” section and selected references, questions and answers appear at the end of each chapter. This new edition has been comprehensively rewritten and restructured to reflect the new technologies, products and trends that have emerged since the original book. Many new aspects highlight the short and longer term commercial potential of food biotechnology.

Modern Biotechnology

Author: Nathan S. Mosier
Publisher: John Wiley & Sons
ISBN: 1118210204
Size: 69.36 MB
Format: PDF, Kindle
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Biotechnology introduces students in science, engineering, or technology to the basics of genetic engineering, recombinant organisms, wild-type fermentations, metabolic engineering and microorganisms for the production of small molecule bioproducts. The text includes a brief historical perspective and economic rationale on the impact of regulation on biotechnology production, as well as chapters on biotechnology in relation to metabolic pathways and microbial fermentations, enzymes and enzyme kinetics, metabolism, biological energetics, metabolic pathways, nucleic acids, genetic engineering, recombinant organisms and the production of monoclonal antibodies.

Introduction To Biochemical Engineering

Author: Dubasi Govardhana Rao
Publisher: Tata McGraw-Hill Education
ISBN: 1259081710
Size: 46.86 MB
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"Designed for an introductory course on Biochemical Engineering, this book interweaves bioprocessing with chemical reaction engineering concepts"--Back cover.

Bioprocess Engineering

Author: Bjorn K. Lydersen
Publisher: Wiley-Interscience
ISBN:
Size: 17.79 MB
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Divided into four sections, the first and third reflect the fact that there are two types of equipment required in the plant--one in which the actual product is synthesized or processed such as the fermentor, centrifuge and chromatographic columns; and the other that supplies support for the facility or process including air conditioning, water and waste systems. Part two describes such components as pumps, filters and valves not limited to a certain type of equipment. Lastly, it covers planning and designing the entire facility along with requirements for containment and validation of the process.