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Genomic Diversity

Author: Surinder Singh Papiha
Publisher: Springer Science & Business Media
ISBN: 1461542634
Size: 48.48 MB
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One of the major themes of human population genetics is assaying genetic variation in human populations. The ultimate goal of this objective is to understand the extent of genetic diversity and the use of this knowledge to reconstruct our evolutionary history. The discipline had undergone a revolutionary transition with the advent of molecular techniques in the 1980s. With this shift, statistical methods have also been developed to perceive the biological and molecular basis of human genetic variation. Using the new perspectives gained during the above transition, this volume describes the applications of molecular markers spanning the autosomal, Y-chromosomal and mitochondrial genome in the analysis of human diversity in contemporary populations. This is the first reference book of its kind to bring together data from these diverse sets of markers for understanding evolutionary histories and relationships of modern humans in a single volume.

Anthropological Genetics

Author: Michael H. Crawford
Publisher: Cambridge University Press
ISBN: 9780521546973
Size: 73.28 MB
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Volume detailing the effects of the molecular revolution on anthropological genetics and how it redefined the field.

Out Of Eden The Peopling Of The World

Author: Stephen Oppenheimer
Publisher: Hachette UK
ISBN: 1780337531
Size: 62.93 MB
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In a brilliant synthesis of genetic, archaeological, linguistic and climatic data, Oppenheimer challenges current thinking with his claim that there was only one successful migration out of Africa. In 1988 Newsweek headlined the startling discovery that everyone alive on the earth today can trace their maternal DNA back to one woman who lived in Africa 150,000 years ago. It was thought that modern humans populated the world through a series of migratory waves from their African homeland. Now an even more radical view has emerged, that the members of just one group are the ancestors of all non-Africans now alive, and that this group crossed the mouth of the Red Sea a mere 85,000 years ago. It means that not only is every person on the planet descended from one African 'Eve' but every non-African is related to a more recent Eve, from that original migratory group. This is a revolutionary new theory about our origins that is both scholarly and entertaining, a remarkable account of the kinship of all humans. Further details of the findings in this book are presented at www.bradshawfoundation.com/stephenoppenheimer/

Human Population Genetics And Genomics

Author: Alan R. Templeton
Publisher: Academic Press
ISBN: 0123860261
Size: 71.20 MB
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Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now

Human Population Genetic Research In Developing Countries

Author: Yue Wang
Publisher: Routledge
ISBN: 1135047111
Size: 70.80 MB
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Human population genetic research (HPGR) seeks to identify the diversity and variation of the human genome and how human group and individual genetic diversity has developed. This book asks whether developing countries are well prepared for the ethical and legal conduct of human population genetic research, with specific regard to vulnerable target group protection. The book highlights particular issues raised by genetic research on populations as a whole, such as the potential harm specific groups may suffer in genetic research, and the capacity for current frameworks of Western developed countries to provide adequate protections for these target populations. Using The People’s Republic of China as a key example, Yue Wang argues that since the target groups of HPGR are almost always from isolated and rural areas of developing countries, the ethical and legal frameworks for human subject protection need to be reconsidered in order to eliminate, or at least reduce, the vulnerability of those groups. While most discussion in this field focuses on the impact of genetic research on individuals, this book breaks new ground in exploring how the interests of target groups are also seriously implicated in genetic work. In evaluating current regulations concerning prevention of harm to vulnerable groups, the book also puts forward an alternative model for group protection in the context of human population genetic research in developing countries. The book will be of great interest to students and academics of medical law, ethics, and the implications of genetic research.

Evaluating Human Genetic Diversity

Author: National Research Council
Publisher: National Academies Press
ISBN: 9780309184748
Size: 47.76 MB
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This book assesses the scientific value and merit of research on human genetic differences--including a collection of DNA samples that represents the whole of human genetic diversity--and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.

Dna Fingerprinting

Author: Sergio D. Pena
Publisher: Springer Science & Business Media
ISBN: 9783764329068
Size: 71.39 MB
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DNA fingerprinting had a well-defined birthday. In the March 7, 1985 issue of Nature, Alec Jeffreys and coworkers described the first develop ment ofmu1tilocus probes capable of simultaneously revealing hypervari ability at many loci in the human genome and called the procedure DNA fingerprinting. It was a royal birth in the best British tradition. In a few months the emerging technique had permitted the denouement of hith erto insoluble immigration and paternity disputes and was already heralded as a major revolution in forensic sciences. In the next year (October, 1986) DNA fingerprinting made a dramatic entree in criminal investigations with the Enderby murder case, whose story eventually was turned into a best-selling book ("The Blooding" by Joseph Wambaugh). Today DNA typing systems are routinely used in public and commercial forensic laboratories in at least 25 different countries and have replaced conventional protein markers as the methods of choice for solving paternity disputes and criminal cases. Moreover, DNA fingerprinting has emerged as a new domain of intense scientific activity, with myriad applications in just about every imaginable territory of life sciences. The Second International Conference on DNA Fingerprinting, which was held in Belo Horizonte, Brazil in November of 1992, was a clear proof of this.