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Gnotobiotic Mouse Technology

Author: Chriss J. Vowles
Publisher: CRC Press
ISBN: 1498736335
Size: 75.79 MB
Format: PDF
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The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of establishing and operating a germ-free mouse research facility, from basic principles and equipment to detailed instructions for assembling and maintaining isolators, sterilizing supplies, handling animals, and monitoring sterility. The book breaks down techniques and procedures into modules, each of which contains a step-by-step practical and visual guide to a set of related procedures. Each description consists of a materials list, introduction, and general overview, followed by a thoroughly illustrated walkthrough of the steps for each procedure. The descriptions end with troubleshooting tips. Technical chapters are heavily illustrated and include notations of potential pitfalls and alternatives. Other chapters discuss management procedures and practices such as the hiring and training of personnel, setting fee schedules, and record keeping. This book is a landmark resource for establishing and maintaining a facility for germ-free mouse research. Useful to both technicians and investigators, it presents every step necessary to establish a successful facility. It also gives direction in expanding multi-user facilities and applying new technologies to your current practices.

Animal Models For Microbiome Research

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309463912
Size: 17.65 MB
Format: PDF
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The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop.

Gnotobiotics

Author: Trenton R Schoeb
Publisher: Academic Press
ISBN: 0128045833
Size: 26.64 MB
Format: PDF, ePub
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Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility

The Gut Microbiome In Health And Disease

Author: Dirk Haller
Publisher: Springer
ISBN: 3319905457
Size: 41.67 MB
Format: PDF, ePub, Mobi
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The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology.

Naturgeschichte Der Infektionskrankheiten Des Menschen

Author: Frank Macfarlane Burnet
Publisher: S. Fischer Verlag
ISBN: 3105614095
Size: 71.40 MB
Format: PDF, ePub, Docs
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Der Nobelpreisträger Frank Macfarlane Burnet schildert die Infektionskrankheiten als ein Schlüsselthema der Conditio humana. Er zeigt, wie sich in dem die Erkrankung auslösenden Kampf zwischen Erreger und Opferorganismus Grundprozesse des Lebens, Wachstum und Tod, enthüllen. Das Buch gibt Einblick in den chemischen Bauplan der Erreger, schildert anschaulich die Angriffs- und Abwehrstrategien, die komplizierten ökologischen Beziehungen des Menschen zu den Organismen seiner Umwelt. Indem es die schrittweise Eindämmung großer Seuchen, die jahrtausendelang die Menschheit dezimiert haben, nacherzählt, aber auch die Negativfolgen dieses Fortschritts – die Gefahr der Übervölkerung und die Entwicklung biologischer Massenvernichtungsmittel – eindringlich beim Namen nennt, ist das Buch gleichzeitig ein fesselndes Stück Evolutions-, Wissenschafts- und Kulturgeschichte. (Dieser Text bezieht sich auf eine frühere Ausgabe.)

Struma

Author: Johannes Köbberling
Publisher: Springer-Verlag
ISBN: 3642883133
Size: 62.36 MB
Format: PDF, ePub, Mobi
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Darmgesundheit Und Mikrobiota

Author: Dirk Haller
Publisher: Springer-Verlag
ISBN: 3658076488
Size: 76.70 MB
Format: PDF, Kindle
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Dirk Haller und Gabriele Hörmannsperger geben einen Überblick über die zentrale Rolle des Darms und seiner Bewohner für die Gesundheit und vermitteln zusätzlich einen ersten Eindruck von den komplexen und dynamischen Interaktionen zwischen D+armbakterien und Wirt. Denn Forschungsergebnisse der letzten Jahre weisen darauf hin, dass die lange unbeachteten Darmbakterien (intestinale Mikrobiota) eine unerwartet zentrale Rolle für die Aufrechterhaltung der Gesundheit einnehmen. Die Forschung beschäftigt sich aktuell intensiv damit, die Grundlagen für ein funktionierendes und gesundheitsförderndes mikrobielles Ökosystem zu identifizieren. Dieses Wissen kann zukünftig für die Entwicklung gezielter Maßnahmen zur Prävention und Therapie Mikrobiota-assoziierter Erkrankungen eingesetzt werden.

German Short Stories For Beginners

Author: Olly Richards
Publisher: Createspace Independent Publishing Platform
ISBN: 9781522741046
Size: 46.66 MB
Format: PDF, ePub, Mobi
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Improve your comprehension, grow your vocabulary and ignite your imagination with these unconventional German short stories!In this book you will find: Short stories from a variety of compelling genres, from science fiction and crime to history and thriller, so you'll have great fun reading, whilst learning a wide range of new vocabulary and rapidly improving your German comprehension! Stories which are broken down into manageable chapters, so you always make progress with the story and feel a sense of achievement without great difficulty reading! Realistic amounts of new vocabulary so that you're not overwhelmed by complex words. Instead of pausing to look up every word, you'll absorb new vocabulary from the context of the story, and have the satisfaction of that moment when you say: "I totally understood that sentence!" Carefully written German, using straightforward grammar that is comprehensible for beginner and intermediate level learners, so that you can enjoy reading and learn new grammatical structures without the feeling of overwhelm and frustration that you get from other books. Plenty of natural dialogues in each story, so that you can learn conversational German whilst you read, and improve your speaking ability at the same time! Regular plot summaries, comprehension questions and word reference lists, so that help is always on hand when you need it. You'll be able to focus on enjoying reading and having fun, rather than fumbling around with dictionaries and struggling through dense text with no support. A five-step plan for reading the stories in this book the smart way. This detailed introductory chapter gives you specific, step-by-step instructions for effective reading in German, so that you know exactly how to make the most out of the book and maximise your learning! German Short Stories for Beginners is written especially for students from beginner to intermediate level (A1-B1 on the Common European Framework of Reference). The eight captivating stories are designed to give you a sense of achievement and a feeling of progress when reading. You'll finally be able to enjoy reading in German, grow your vocabulary in a natural way, and improve your comprehension at the same time.Based on extensive research into how people most enjoy and benefit from reading in a new language, this book eliminates all the frustrations you have experienced when trying to read in German: Dull topics that are no fun to read Books so long you never reach the end Endless chapters that make you want to give up Impenetrable grammar that frustrates you at every turn Complex vocabulary that leaves you with your head buried in the dictionary Instead, you can just concentrate on what you came for in the first place - enjoying reading and having fun!If you're learning German and enjoy reading, this is the book you need to rekindle your passion for the language and take your German to the next level!So what are you waiting for? Scroll up and grab your copy now!