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Intracellular Signaling Mediators In The Circulatory And Ventilatory Systems

Author: Marc Thiriet
Publisher: Springer Science & Business Media
ISBN: 1461443709
Size: 26.46 MB
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The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

Advances In Computational Fluid Structure Interaction And Flow Simulation

Author: Yuri Bazilevs
Publisher: Birkhäuser
ISBN: 3319408275
Size: 78.76 MB
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This contributed volume celebrates the work of Tayfun E. Tezduyar on the occasion of his 60th birthday. The articles it contains were born out of the Advances in Computational Fluid-Structure Interaction and Flow Simulation (AFSI 2014) conference, also dedicated to Prof. Tezduyar and held at Waseda University in Tokyo, Japan on March 19-21, 2014. The contributing authors represent a group of international experts in the field who discuss recent trends and new directions in computational fluid dynamics (CFD) and fluid-structure interaction (FSI). Organized into seven distinct parts arranged by thematic topics, the papers included cover basic methods and applications of CFD, flows with moving boundaries and interfaces, phase-field modeling, computer science and high-performance computing (HPC) aspects of flow simulation, mathematical methods, biomedical applications, and FSI. Researchers, practitioners, and advanced graduate students working on CFD, FSI, and related topics will find this collection to be a definitive and valuable resource.

Signaling At The Cell Surface In The Circulatory And Ventilatory Systems

Author: Marc Thiriet
Publisher: Springer Science & Business Media
ISBN: 1461419913
Size: 64.95 MB
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The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.

Cell And Tissue Organization In The Circulatory And Ventilatory Systems

Author: Marc Thiriet
Publisher: Springer Science & Business Media
ISBN: 144199758X
Size: 18.31 MB
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View: 4373
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The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. The present volume is devoted to cellular events that allow adaptation to environmental conditions, particularly mechanotransduction. It begins with cell organization and a survey of cell types in the vasculature and respiratory tract. It then addresses cell structure and functions, especially in interactions with adjoining cells and matrix.

Geschichte Der Physiologie

Author: Karl E. Rothschuh
Publisher: Springer-Verlag
ISBN: 3642510426
Size: 79.85 MB
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"Geschichte ist die geistige Form, in der sich eine Kultur über ihre Vergangen heit Rechenschaft gibt" (J. HUIZINGA [208J). In diesem Sinne berichtet diese Ge schichte der Physiologie von den Wegen und Umwegen, Erkenntnissen und Irr tümern, welche in der historischen Entwicklung dieser Wissenschaft von wesent licher Bedeutung gewesen sind. Für die Art der Darstellung waren teils äußere Momente, teils bestimmte Absichten des Verfassers maßgeblich. Auf dem knappen Raum, der zur Verfügung stand, konnten nur die großen Linien des geschicht lichen Werdegangs unter Verzicht auf viele Einzelheiten wiedergegeben werden. Deshalb entfiel auch die Möglichkeit, den Entwicklungsgang spezieller Einzel probleme ausführlich zu schildern, wie es etwa F. LIEBEN [244] in seiner Ge schichte der physiologischen Chemie getan hat. Ich konnte aber mit guten Gründen in diesem Buche darauf verzichten, da ich kürzlich eine" Entwicklungsgeschichte physiologischer Probleme in Tabellenform" [342b] veröffentlicht habe, in welcher die schrittweise wachsende Einsicht in die Ursachen und die Bedeutung spezieller physiologischer Vorgänge seit Beginn der Neuzeit nach Autor, ,Jahr, Gegenstand und Veröffentlichungsort dargestellt wurde.

Conference Papers Index

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Size: 21.81 MB
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Monthly. Papers presented at recent meeting held all over the world by scientific, technical, engineering and medical groups. Sources are meeting programs and abstract publications, as well as questionnaires. Arranged under 17 subject sections, 7 of direct interest to the life scientist. Full programs of meetings listed under sections. Entry gives citation number, paper title, name, mailing address, and any ordering number assigned. Quarterly and annual indexes to subjects, authors, and programs (not available in monthly issues).