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Intracellular Traffic And Neurodegenerative Disorders

Author: Peter H. St.George-Hyslop
Publisher: Springer Science & Business Media
ISBN: 3540879412
Size: 17.59 MB
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Many adult onset neurodegenerative diseases arise from the accumulation of misfolded peptides. This book examines the role sub-cellular trafficking pathways play in the pathological accumulation of these misfolded proteins and in attempts to clear them.

Two Faces Of Evil Cancer And Neurodegeneration

Author: Thomas Curran
Publisher: Springer Science & Business Media
ISBN: 9783642166020
Size: 57.40 MB
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Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Neurodegenerative Disorders Loss Of Function Through Gain Of Function

Author: K. Beyreuther
Publisher: Springer Science & Business Media
ISBN: 9783540412182
Size: 36.10 MB
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The main message from this book is that the different protein aggregation processes may all be amenable to a small number of intervention steps based on a common theme of the modulation of production, turnover and deposition of the corresponding disease gene products. The next few years will prove critical in evaluation the possibilities of rational therapeutic strategies towards regaining the loss of function through the amelioration of the abnormal gain of function.

Fatal Attractions Protein Aggregates In Neurodegenerative Disorders

Author: V.M.-Y. Lee
Publisher: Springer Science & Business Media
ISBN: 9783540671725
Size: 74.56 MB
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In this volume are contributions based on a meeting arranged by the WHO and the Fondation IPSEN. The scientists focus on neurodegenerative disorders like Alzheimer's Disease, Chromosome 17-Linked Dementia, Parkinson's Disease and disorders with tauopathies.

Alzheimer S Disease

Author: George Perry
Publisher: IOS Press
ISBN: 9781586036195
Size: 34.61 MB
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"This is the book edition of the Journal of Alzheimer's Disease, Volume 9, No.3 Supplement (2006)"--T.p. verso.

Alzheimer 100 Years And Beyond

Author: Mathias Jucker
Publisher: Springer Science & Business Media
ISBN: 3540376526
Size: 12.85 MB
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Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.

Advances In Alzheimer S And Parkinson S Disease

Author: Abraham Fisher
Publisher: Springer Science & Business Media
ISBN: 9780387720760
Size: 73.29 MB
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This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, which covering topics from immunology, neuroscience, and pharmacology to genetics and molecular biology. Possible future developments in the treatment of Alzheimer’s and Parkinson’s Diseases are also covered.

Oxidative Energy Metabolism In Neurodegenerative Disorders

Author: John Blass
Publisher: New York Academy of Sciences
ISBN: 9781573312097
Size: 60.82 MB
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The topic of energy metabolism in diseases of the brain has re-emerged during the last few years as an area of intense scientific and medical interest. This book brings together basic and clinical investigators in an effort to move studies in this burgeoning area to a more basic mechanistic research level. Neurodegenerative disorders in which there is solid evidence of abnormalities in oxidative/energy metabolism include Alzheimer's disease, Parkinson's disease, Huntington's disease, and other early-onset hereditary disorders, as well as stroke. The authors show that specific neurodegenerative disorders are characterized by particular abnormalities, although within this group of disorders there are also common final paths of tissue damage.

Synaptic Plasticity And The Mechanism Of Alzheimer S Disease

Author: Dennis J. Selkoe
Publisher: Springer Science & Business Media
ISBN: 9783540763307
Size: 30.79 MB
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A biochemical hypothesis - that Alzheimer’s disease (AD) is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies. This volume serves as a record focused on bringing together investigators at the forefront of elucidating the structure and function of hippocampal synapses with investigators focused on understanding how early assemblies of Ab may compromise some of these synapses.