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Introduction To Biomolecular Energetics

Author: Irving Klotz
Publisher: Elsevier
ISBN: 0323160999
Size: 25.97 MB
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Introduction to Biomolecular Energetics Including Ligand-Receptor Interactions focuses on the concepts of energetics and their biological applications, including the study of ligand-receptor interactions. The book provides quantitative calculations and addresses topics that have become more prominent in the biochemical and related sciences in recent years, including the first and second laws of thermodynamics, the concept of entropy, free energy or chemical potential, group-transfer potential, physicochemical behavior, and enzyme kinetics. This volume is organized into 10 chapters, and it begins with an overview of the scope of energetics and two general approaches to the field: the classical or phenomenological approach and the statistical-molecular approach. The chapters that follow explore the concepts of energy and entropy in the context of the first and second laws of thermodynamics, along with the relationships between work, heat, energy and entropy as an index of exhaustion. The discussion then shifts to the free energy function and general procedures for computing standard free energies. The book also introduces the reader to the fundamental relationship between chemical potential (free energy) and concentration; high-energy bond and the concept of group-transfer potential; the use of thermodynamic methods in the analysis of physicochemical behavior; and statistical thermodynamics. The final chapter examines the number of ligands that are bound by the receptor entity, how strongly the ligands are held, and the molecular nature of the forces of ligand-receptor interaction. This book will be of interest to biologists and those who want to understand the principles of energetics governing biochemical changes.

Enzyme Kinetics

Author: Hans Bisswanger
Publisher: John Wiley & Sons
ISBN: 3527806474
Size: 63.78 MB
Format: PDF
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Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.

Ligand Receptor Energetics

Author: Irving M. Klotz
Publisher: John Wiley & Sons
ISBN: 9780471176268
Size: 45.79 MB
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A foundation for quantitative perspectives and a framework forinterpreting experimental observations. Researchers in the life sciences who are unaware of the origins ofthe fundamental concepts and theoretical constructs inligand-receptor energetics may fail to recognize the hiddenassumptions and premises in their interpretations of observedphenomena. This book offers a detailed exposition of thesefundamentals and of the treatment of multiple equilibria insuccessive steps of the binding of ligands to receptors. It alsodescribes the calculations and meanings of energetic quantities forligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that isboth accessible to beginners and extremely useful for experiencedinvestigators. It features numerous specific examples; tables ofliterature results; extensive, up-to-date thermodynamic data;graphical representations of ligand bonding concepts; and fourhelpful appendices. Topics covered include: * Affinities -from site, stoichiometric, and ghost-siteperspectives * Facts and fantasies from graphical analyses * Numerical evaluation of stoichiometric binding constants * Affinity profiles * Thermodynamic perspectives * Forces of interaction * Molecular scenarios. This valuable supplementary text for students in all areas of thebasic life sciences is also an excellent professional reference forresearchers in biochemistry, molecular biology, physiology,biophysics, microbiology, neurobiology, immunology, pharmacology,endocrinology, and toxicology.

Cellular And Biomolecular Recognition

Author: Raz Jelinek
Publisher: John Wiley & Sons
ISBN: 3527627022
Size: 19.39 MB
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With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.

Diamond Dealers And Feather Merchants

Author: KLOTZ
Publisher: Springer Science & Business Media
ISBN: 1489935290
Size: 69.39 MB
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To paraphrase Saul Bellow, it is extremely difficult to escape from the conceptual bottles into which we have been processed, or even to become aware that we are confined within them. Anthro pocentrism, an ancient tradition, is an intellectual constraint that has continually impeded objective probing of the universe around and within us. We are probably born with that constriction, perhaps as a result of evolutionary selection or because each of us has been created in the image of the Deity. But it is only the core of our mental "gestalt. " Around it we find additional shells of intellectual obstruc tions deposited by accretion from our family, our teachers, our experi ences and the society in which we are immersed. It is very hazardous to embrace novel scientific ideas. Personal and social experiences show that the vast majority turn out to be failures. What standards can one use to make judgments? There is a universal tendency to rely on "common sense;" but as Einstein pointed out, this is a collection of views, sensible or not, imprinted in us before the age of sixteen. I have found it a challenge to convince young students that much of what they are certain about and, in fact, correct about, is actually contrary to common sense. For example, on any bright day, anyone who is not blind or an idiot can see the sun literally moving around the earth, from east to west.

Chemical Thermodynamics

Author: Irving M. Klotz
Publisher: Wiley-Interscience
ISBN: 9780471780151
Size: 35.38 MB
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A completely updated, expanded edition of a longstanding and influential text on chemical thermodynamics Covers the logical foundations and interrelationships of thermodynamics and their application to problems that are commonly encountered by the chemist. Explanations of abstract concepts in a clear and simple, yet still rigorous fashion Logical arrangement of the material to facilitate learning, including worked out examples. Computational techniques, graphical, numerical, and analytical, are described fully and are used frequently, both in illustrative and in assigned problems.

Applied Cell And Molecular Biology For Engineers

Author: Gabi Nindl Waite
Publisher: McGraw Hill Professional
ISBN: 9780071509527
Size: 16.96 MB
Format: PDF, Kindle
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A Guide to the Fundamentals and Latest Concepts of Molecular and Cell Biology Bridging the gap between biology and engineering, Applied Cell and Molecular Biology for Engineers uses clear, straightforward language to introduce you to the cutting-edge concepts of molecular and cell biology. Written by an international team of engineers and life scientists, this vital tool contains “clinical focus boxes” and “applications boxes” in each chapter to link biology and engineering in today's world. To help grasp complex material quickly and easily, a glossary is provided. Applied Cell and Molecular Biology for Engineers features: Clear descriptions of cell structures and functions Detailed coverage of cellular communication In-depth information on cellular energy conversion Concise facts on information flow across generations A succinct guide to the evolution of cells to organisms Inside This Biomedical Engineering Guide Biomolecules: • Energetics • Components of the cell • Cell Morphology: • Cell membranes • Cell organelles • Enzyme Kinetics: • Steady-state kinetics • Enzyme inhibition • Cellular Signal Transduction: • Receptor binding • Apoptosis • Energy Conversion: • Cell metabolism • Cell respiration • Cellular Communication: • Direct • Local • Long distance • Cellular Genetics: • DNA and RNA synthesis and repair • Cell Division and Growth: • Cell cycle • Mitosis • Stem cells • Cellular Development: • Germ cells and fertilization • Limb development • From Cells to Organisms: • Cell differentiation • Systems biology

Molecular Design

Author: A.L. Horvath
Publisher: Elsevier
ISBN: 0444596739
Size: 69.76 MB
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This book is a systematic presentation of the methods that have been developed for the interpretation of molecular modeling to the design of new chemicals. The main feature of the compilation is the co-ordination of the various scientific disciplines required for the generation of new compounds. The five chapters deal with such areas as structure and properties of organic compounds, relationships between structure and properties, and models for structure generation. The subject is covered in sufficient depth to provide readers with the necessary background to understand the modeling techniques. The book will be of value to chemists in industries involved in the manufacture of organic chemicals such as solvents refrigerants, blood substitutes, etc. It also serves as a reference work for researchers, academics, consultants, and students interested in molecular design.

Analyzing Biomolecular Interactions By Mass Spectrometry

Author: Jeroen Kool
Publisher: John Wiley & Sons
ISBN: 3527334645
Size: 51.47 MB
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This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

Biological Thermodynamics

Author: Donald T. Haynie
Publisher: Cambridge University Press
ISBN: 9780521795494
Size: 64.73 MB
Format: PDF, Mobi
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An accessible introduction to thermodynamics for undergraduate biology and biochemistry students.