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Introduction To Enzyme And Coenzyme Chemistry

Author: T. D. H. Bugg
Publisher: John Wiley & Sons
ISBN: 1118348990
Size: 32.45 MB
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Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Introduction To Enzyme And Coenzyme Chemistry

Author: T. D. H. Bugg
Publisher: John Wiley & Sons
ISBN: 1405148004
Size: 11.96 MB
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Enzyme catalysis is a topic of fundamental importance in organic, bio-organic and medicinal chemistry. This new edition of a very popular textbook provides a concise introduction to the underlying principles and mechanisms of enzyme and coenzyme action from a chemical perspective. Whilst retaining the overall structure of the first edition – preliminary chapters describe the basic principles of enzyme structure and catalysis moving through to detailed discussions of the major classes of enzyme processes in the later chapters – the book has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action. A major feature of the second edition is the inclusion of two-colour figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. Problems, with outline answers, at the end of each chapter give the student the chance to the check their understanding of the material. As a concise but comprehensive account, Introduction to Enzyme and Coenzyme Chemistry will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry. Tim Bugg is professor of biological chemistry in the Department of Chemistry, University of Warwick, UK.

Introduction To Enzyme And Coenzyme Chemistry

Author: Tim Bugg
Publisher: John Wiley & Sons
ISBN: 1119995949
Size: 75.14 MB
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Looking at enzymes from an organic chemistry perspective, this updated reference includes information on recent advances in our understanding of enzyme action; topical examples to illustrate key points; two-color figures of the active sites of enzymes discussed in the text to illustrate the interplay between enzyme structure and function; and end-of-chapter problems to allow readers to check their understanding of the material. This concise but comprehensive guide is essential for undergraduate and postgraduate students of organic, bio-organic, and medicinal chemistry, chemical biology, biochemistry, and biotechnology.

Enzyme Kinetics Catalysis And Control

Author: Daniel L. Purich
Publisher: Elsevier
ISBN: 0123809258
Size: 69.11 MB
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Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Organic Chemistry Of Enzyme Catalyzed Reactions Revised Edition

Author: Richard B. Silverman
Publisher: Elsevier
ISBN: 0080513360
Size: 37.58 MB
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The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed. This is a revised edition of a very successful book, which appeals to both academic and industrial markets. Illustrates the organic mechanism associated with each enzyme-catalyzed reaction Makes the connection between organic reaction mechanisms and enzyme mechanisms Compiles the latest information about molecular mechanisms of enzyme reactions Accompanied by clearly drawn structures, schemes, and figures Includes an extensive bibliography on enzyme mechanisms covering the last 30 years Explains how enzymes can accelerate the rates of chemical reactions with high specificity Provides approaches to the design of inhibitors of enzyme-catalyzed reactions Categorizes the cofactors that are appropriate for catalyzing different classes of reactions Shows how chemical enzyme models are used for mechanistic studies Describes catalytic antibody design and mechanism Includes problem sets and solutions for each chapter Written in an informal and didactic style

Experiments In The Purification And Characterization Of Enzymes

Author: Thomas E. Crowley
Publisher: Academic Press
ISBN: 0124095933
Size: 26.55 MB
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Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual provides students with a working knowledge of the fundamental and advanced techniques of experimental biochemistry. Included are instructions and experiments that involve purification and characterization of enzymes from various source materials, giving students excellent experience in kinetics analysis and data analysis. Additionally, this lab manual covers how to evaluate and effectively use scientific data. By focusing on the relationship between structure and function in enzymes, Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual provides a strong research foundation for students enrolled in a biochemistry lab course by outlining how to evaluate and effectively use scientific data in addition to offering students a more hands-on approach with exercises that encourage them to think deeply about the content and to design their own experiments. Instructors will find this book useful because the modular nature of the lab exercises allows them to apply the exercises to any set of proteins and incorporate the exercises into their courses as they see fit, allowing for greater flexibility in the use of the material. Written in a logical, easy-to-understand manner, Experiments in the Purification and Characterization of Enzymes: A Laboratory Manual is an indispensable resource for both students and instructors in the fields of biochemistry, molecular biology, chemistry, pharmaceutical chemistry, and related molecular life sciences such as cell biology, neurosciences, and genetics. Offers project lab formats for students that closely simulate original research projects Provides instructional guidance for students to design their own experiments Includes advanced analytical techniques Contains adaptable modular exercises that allow for the study proteins other than FNR, LuxG and LDH Includes access to a website with additional resources for instructors

The Biological Chemistry Of Nickel

Author: Deborah Zamble
Publisher: Royal Society of Chemistry
ISBN: 1788010582
Size: 73.72 MB
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Nickel is an essential element in many biochemical processes and there has been significant research into understanding in great depth the role that this transition element plays. This book provides a comprehensive review of the latest findings in nickel biology, covering the function, biochemistry, toxicology and medical applications of nickel systems. Chapters discuss a range of topics in this field including the coordination chemistry of nickel-containing biomolecules, current theories on nickel-containing enzymes and the transport, storage and transcriptional regulation of nickel in biological systems. Issues such as the key role of nickel in pathogens, nickel toxicity in humans and the potential medical applications are also examined. Written by internationally leading experts in nickel biology and chemistry research, this book is an essential reference for bioinorganic chemists, biochemists, biologists and medicinal chemists.

Introduction To Modern Biochemistry

Author: P Karlson
Publisher: Academic Press
ISBN: 1483267784
Size: 10.94 MB
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Introduction to Modern Biochemistry, Second Edition focuses on the methodologies, processes, reactions, and technologies involved in biochemistry. The publication first takes a look at organic chemistry and biochemistry, amino acids, and peptides. Discussions focus on the determination of amino acid sequence in peptides, naturally occurring peptides, chemical properties, separation of amino acids, hydrocarbons as parent substances, functional groups, polymeric compounds, and reactions with biochemical significance. The text then ponders on proteins, enzymes and biocatalysis, and coenzymes. The manuscript examines nucleic acids and protein biosynthesis, metabolism of proteins, and porphyrins and hemins. Topics include chemical constitution of heme, significance and reactions of blood pigment, metabolism of aromatic amino acids, degradation to activated fatty acids, decarboxylation of amino acids, and biosynthesis and degradation of nucleotides. The text also ponders on carbon dioxide formation in the citrate cycle, fats and fat metabolism, and phosphatides, cerebrosides, and gangliosides. The book is a valuable reference for biochemists and researchers interested in the processes, approaches, and technologies involved in biochemistry.

Introduction To Enzymology

Author: Alan H. Mehler
Publisher: Elsevier
ISBN: 1483258475
Size: 25.73 MB
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Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

Bioorganic Chemistry

Author: Hermann Dugas
Publisher: Springer
ISBN:
Size: 11.56 MB
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Introduction to bioorganic chemistry; Bioorganic chemistry of the amino acids; Bioorganic chemistry of the phosphates; Enzyme chemistry; Enzyme models; Metal ions; Coenzyme chemistry.