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Introduction To Enzyme And Coenzyme Chemistry

Author: T. D. H. Bugg
Publisher: John Wiley & Sons
ISBN: 1118348990
Size: 59.75 MB
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Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Advances In Heterocyclic Chemistry

Author: Alan R. Katritzky
Publisher: Academic Press
ISBN: 9780123813077
Size: 56.17 MB
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Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers

Introduction To Agricultural Biochemistry

Author: Raymond Adam Dutcher
Publisher: Daya Books
ISBN: 9788176221405
Size: 45.61 MB
Format: PDF, Docs
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This Book Is Divided Into 3 Parts. Part 1 Is Designed To Stimulate Interest By Introducing The Student To Some Of The Interesting And Significant Reasons For The Study Of Agricultural Biochemistry, To Review The Organic Chemistry Of Compounds Of Biological Importance, And To Introduce Definitions, Terms, And Mechanisms Which Will Help The Student Understand And Appreciate Material Presented In Subsequent Chapters. Part 2 (The Plant) Involves A Discussion Of The More Important Chemical Facts And Theories Relating To Plant Growth, From The Time The Seed Germinates Until It Becomes A Mature Plant. The Chapter On Farm Chemurgy Is Designed To Acquaint The Student With Actual And Potential Utilization Of Farm Crops For Industrial Purposes. Part 3 (The Animal) Has Been Written With The View Of Stressing, So Far As Possible, The Biochemical Phases Of Metabolism And Growth. Practical Applications Have Not Been Stressed Since This Can Be Done To Better Advantage In Subsequent Practical Courses Dealing With Livestock Feeds And Feeding. Tables Of Recommended Nutrient Allowances For Humans And Domestic Animals And Tables Of Chemical Composition Of Some Selected Human Foods And Livestock Feeds Have Been Placed In The Appendix For Reference Purposes. The Book Has Been Written On The Assumption That It Will Be Suitable For Students With Sound Training In Inorganic And Organic Chemistry. It Is Hoped That The Present Volume Will Stimulate Interest In The Teaching Of Agricultural Biochemistry And That It Will Also Serve As A General Reference Book For Students Who Are Interested In The Underlying Chemical Principles Affecting Plant And Animal Growth. Contents Part I: General And Introductory; Chapter 1: The Development Of Agricultural Chemistry, The Influence Of Alchemy, The Beginning Of Genuine Chemistry, Search For The Principle Of Vegetation , The Beginning Of Modern Agricultural Science, The Beginnings Of Physiological Chemistry, Beginning Of Agricultural Science In America; Chapter 2: Chemistry Of Living Matter, Properties Of Living Things, The Cell, Protoplasm, Importance Of Water, Inorganic Salts; Chapter 3: Physical State Of Matter, Some Properties Of Solutions, Dissociation, Osmosis And Osmotic Pressure, Surface Tension, Acids And Bases, Dissociation Of Water, Hydronium Ion Concentration And Ph, Buffers, The Colloidal State; Chapter 4: Carbohydrates, General Characteristics Of Carbohydrates, Nomenclature, Classification Of Important Carbohydrates, Monosaccharides, Disaccharides, Polysaccharides, Compounds Allied To The Carbohydrates, Reactions Of Carbohydrates; Chapter 5: The Lipids, General Characteristics, Classification Of Lipids, Fatty Acids And Glycerol, Fats And Oils, Fat Analysis, Waxes, Sterols, Phospholipids, Glycolipids, Essential Or Volatile Oils; Chapter 6: Proteins, General Properties And Composition Of Proteins, Classification Of Proteins, Amino Acids, Peptide Formation, Molecular Weight Of Proteins, Structure Of Proteins, Chemical Tests, Nucleoproteins; Chapter 7: Enzymes, General Characteristics, Nomenclature, Occurrence And Distribution, Classification, Preparation And Crystallization, Factors Affecting Enzyme Activity, Esterases, Carbohydrates, Proteinases, Peptidases, Aminases, Amidases, Desmolases, Practical Applications Of Enzymes As Catalysts; Chapter 8: Biological Oxidations, Oxidation And Reduction, Theories Of Biological Oxidations, General Mechanism Of Biological Oxidation, Intermediary Steps In Carbohydrate Metabolism, The Krebs Citric Acid Cycle; Protein Metabolism, Fat Metabolism, Transfer Of Electrons And Protons, Coenzyme 1, Coenzyme 2, Flavoproteins, Cytochromes, Energy Transfer In Metabolism, Other Oxidizing Enzymes. Part Ii: The Plant; Chapter 9: Seed Germination, Chemical Composition Of Seeds, Factors Influencing The Process Of Seed Germination, Metabolism Of Germinating Seeds; Chapter 10: The Soil And Its Relation To Plant Growth, The Soil, Inorganic Matter In Soils, Soil Organic Matter, Humus, Soil Colloids, Base Exchange, The Soil Solution, Absorption Of Plant Nutrients, Soil Nutrients And Their Utilisation By Plants, Other Macronutrient Elements, Micronutrient Elements; Chapter 11: Fertilizers, Nitrogenous Fertilizers, Phosphate Fertilizers, Potash Fertilizers, Farm Manure, Effects Of Manure On Soil; Chapter 12: Plant Metabolism, Carbohydrate Metabolism, Photosynthesis, Protein Metabolism, Lipid Metabolism; Chapter 13: Pesticides, General Characteristics, Fungicides, Herbicides, Insecticides, Fumigants, Insecticides Obtained From Plants, Miscellaneous Pesticides, Spray Residues; Chapter 14: Farm Chemurgy, Origin Of Chemurgy, Industrial Products Made From Fats And Oils, Industrial Products Made From Carbohydrates, Fiber Products, Textile Products, Industrial Chemicals, Industrial Uses Of Protein, Industrial Uses Of Natural Chemical Products, Commercial Utilisation Of Packing-Plant Residues. Part Iii: The Animal; Chapter 15: Food And Feeding Stuffs, Chemical Composition, Feed Analysis, Stock Feeds Of Plant Origin, Stock Feeds Of Animal Origin; Chapter 16: Digestion Of Foods, Salivary Digestion, Stomachic Characteristics Of Birds And Ruminants, Gastric Digestion, Intestinal Digestion, Characteristics Of Digestive Juices, Absorption Of Nutrients, Detoxication; Chapter 17: The Chemistry Of Blood, Lymph, And Body Tissues, Characteristics And Composition Of Blood And Lymph, Supporting Tissues, Muscle Tissue, Nervous Tissue, Reserve Tissues, Glandular Tissues, Hormones; Chapter 18: The Vitamins, Dietary Deficiency Diseases And The Discovery Of Vitamins, Water-Soluble Vitamins (Deficiency Symptoms, Chemistry, Function, Requirements Of Humans And Domestic Animals, Distribution In Foods), Fat-Soluble Vitamins (Deficiency Symptoms, Chemistry, Function, Requirements Of Humans And Domestic Animals, Distribution In Foods), Vitamin Assay Methods; Chapter 19: Energy Metabolism, Gross Energy Of Foods, Measurement Of Heat Of Combustion, Digestible Nutrients, Oxidation Of Protein, Significance Of The Respiratory Quotient, Basal Metabolism, Factors Affecting Heat Production, Direct Calorimetry, Indirect Calorimetry, Metabolizable Energy, Energy Allowances For Humans And Domestic Animals; Chapter 20: Carbohydrate Metabolism, Phosphorylation, Glycogen, Di- And Tri-Phosphates Of Adenosine, Phosphocreatine, Blood Sugar, Glycogenesis, Glycogenolysis, Glucose Metabolism In Muscle, Abnormal Carbohydrate Metabolism; Chapter 21: Lipid Metabolism, Function Of The Liver, Fat Formed From Carbohydrates And Proteins, Food Fat And Body Fat, Oxidation Of Fats, Essential Fatty Acids, Cholesterol Metabolism; Chapter 22: Protein Metabolism, Nitrogenous Equilibrium, Fate Of Absorbed Protein, Protein Storage And Conservation, Deamination, Transamination, Urea Formation, Formation Of Ammonia, Fate Of Deaminized Residues, Creatine And Creatinine, Transmethylation, Conjugated Proteins, Purines, Pyrimidines; Chapter 23: Protein Nutrition, Protein Quality, Essential Amino Acids, Amino Acid Requirements Of The Rat, Amino Acid Requirements Of Man, Biological Value Of Proteins, Amino Acid Content Of Proteins, Protein Supplementation, Protein Hydrolyzates, Protein Allowances For Humans And Domestic Animals; Chapter 24: Mineral Metabolism, Functions Of Mineral Elements, Deficiency Diseases Caused By Lack Of Essential Mineral Elements, Utilisation And Excretion; Chapter 25: Mineral Nutrition, Mineral Elements Important In Normal Feeding Practice, Balance Experiments, Human Foods As Sources Of Minerals, Mineral Requirements Of Humans, Effect Of Inadequate Mineral Intakes, Mineral Requirements Of Domestic Animals.

Bioorganic Chemistry

Author: Hermann Dugas
Publisher: Springer Science & Business Media
ISBN: 1461224268
Size: 35.17 MB
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This widely-praised textbook is particularly suited for advanced undergraduates or graduates in chemistry, biochemistry, medicinal chemistry, and pharmacology. The third edition has been substantially revised to reflect new research in the field, and features a major new chapter on self-assembly, auto-organization, and molecular devices. The outstanding figures remain a highlight of the book, and were described in an earlier edition as "the best I've seen for showing the organic chemistry of biomolecules." (Quart. Rev. Biol.)

Encyclopedia Of Science And Technology

Author: James S. Trefil
Publisher: Taylor & Francis
ISBN: 9780415937245
Size: 53.36 MB
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Presents nearly one thousand entries and 750 illustrations on science and technology, with bibliographies after each entry and sidebars containing relevant facts.

Enzyme Chemistry

Author: Colin J. Suckling
Publisher: Springer Science & Business Media
ISBN: 940095574X
Size: 41.65 MB
Format: PDF, Kindle
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In the molecular sciences, enzyme chemistry occupies a special niche as one of the major contact points between chemical and biological disciplines. The special properties of enzymes as selective and efficient catalysts are so central to current challenges to chemists that the development of enzyme chemistry in the past thirty years has been a major stimulus to chemical research in general. On the one hand studies of the intrinsic properties of enzymes and, on the other hand, their applications to synthesis, drug design, and biosynthesis have had an immense impact. This book brings together in one volume essays describing several such fields with emphasis on the applications. It would be unnecessarily repetitious to outline the approach and contents of the book in a Preface; the first short chapter is more eloquent than a formal Preface can be. I shall therefore encourage you to begin with the Introduction in Chapter 1 and here I wish to extend my warm thanks to those who have contributed to the production of this book: the authors for their acceptance of the overall concept of the book and for the thoughtfulness of their writing; Dr Charles Suckling, FRS and Professor Hamish Wood for their constructive criticism of the whole book; and Dr John Buckingham and his colleagues at Chapman and Hall for their efficiency and enthusiasm in transforming the typescripts into the book that you now hold. Colin J. Suckling University of Strathclyde Contributors Donald H.

Biological Inorganic Chemistry

Author: Robert R. Crichton
Publisher: Elsevier
ISBN: 044453783X
Size: 47.90 MB
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Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Second Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. Beginning with an overview of metals and selected nonmetals in biology, the book then discusses the following concepts: basic coordination chemistry for biologists; structural and molecular biology for chemists; biological ligands for metal ions; intermediary metabolism and bioenergetics; and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment. Winner of a 2013 Textbook Excellence Awards (Texty) from the Text and Academic Authors Association Readable style, complemented by anecdotes and footnotes Enables the reader to more readily grasp the biological and clinical relevance of the subject Color illustrations enable easy visualization of molecular mechanisms