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Introduction To Molecular Vaccinology

Author: Matthias Giese
Publisher: Springer
ISBN: 331925832X
Size: 75.62 MB
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This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Molekulare Virologie

Author: Susanne Modrow
Publisher: Springer-Verlag
ISBN: 3827422418
Size: 35.78 MB
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Vom Gen zur Pathogenese Das Lehrbuch Molekulare Virologie, seit vielen Jahren als unentbehrliches Standardwerk für Fachleute und Studenten etabliert, liegt nun wieder in einer überarbeiteten und erweiterten Neuauflage vor. Neben der durchgängigen Aktualisierung der Inhalte und Literaturzitate sind unter anderem Layout und Format des Buches angepasst sowie die eingestreuten Exkurse, die schlaglichtartig interessante Einzelthemen beleuchten, thematisch differenziert worden. Durch Einbindung eines zusätzlichen Autors sind zudem humanmedizinisch-klinische Aspekte nun noch stärker berücksichtigt. Molekulare Virologie ist eine Einführung in die molekular- und zellbiologischen Grundlagen von Virusinfektionen bei Mensch und Tier. Das Buch vermittelt einen ausgewogenen Überblick über humanpathogene und tierpathogene Viren. Mit seiner klaren Gliederung und verständlichen Darstellung weist dieses systematisch angelegte Lehr- und Nachschlagewerk sowohl Studenten und Dozenten der Biologie, Human- und Veterinärmedizin als auch Virologen, forschungsorientierten Klinikern, Tierärzten und Seuchenmedizinern sowie Fachleute in Mikrobiologie, Hygiene und Diagnostik den Weg durch die Vielfalt der virologischen Forschungsergebnisse. Im ersten Teil des Buches arbeiten die Autoren die allgemeinen Prinzipien der Struktur, Vermehrung und Lebenszyklen von Viren heraus und beschreiben die wichtigsten pathogenetischen und immunologischen Mechanismen viraler Erkrankungen. Auch die Diagnostik und Therapie sowie die Epidemiologie solcher Infektionen und das heutige Methodenrepertoire der Virologen werden hier vorgestellt. Der zweite, spezielle Teil führt dann systematisch durch die Vielfalt der human- und tierpathogenen Viren. Ausführlich werden zum einen die Morphologie, die Genomorganisation und die Proteinaustattung sowie die Replikationsmechanismen der verschiedenen Virusfamilien dargestellt. Für die jeweils wichtigsten Vertreter präsentieren die Autoren zum anderen einen Überblick über die relevanten humanmedizinisch-klinischen beziehungsweise veterinärmedizinischen Aspekte. Auch seuchenrechtliche Aspekte kommen hier zur Sprache. Dem Autorenteam gelingt es mit diesem Werk erneut, Virologie in ihrer ganzen Spannbreite - vom Molekül bis zur Klinik - überschaubar zu machen. Mit der konsequenten Verknüpfung dieser beiden Zugänge schlägt dieses Werk zudem dringend benötigte Brücken zwischen (molekular)biologischer Grundlagenforschung und medizinischer Anwendung.

Vaccinology

Author: Alan D. T. Barrett
Publisher: John Wiley & Sons
ISBN: 0470656166
Size: 57.79 MB
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Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Cancer Theranostics

Author: Xiaoyuan Chen
Publisher: Academic Press
ISBN: 0124078842
Size: 18.11 MB
Format: PDF, Kindle
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Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Bioinformatics For Vaccinology

Author: Darren R. Flower
Publisher: John Wiley & Sons
ISBN: 0470699825
Size: 37.70 MB
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“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Vaccine Analysis Strategies Principles And Control

Author: Brian K. Nunnally
Publisher: Springer
ISBN: 3662450240
Size: 45.76 MB
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This book is an indispensable tool for anyone involved in the research, development, or manufacture of new or existing vaccines. It describes a wide array of analytical and quality control technologies for the diverse vaccine modalities. Topics covered include the application of both classical and modern bio-analytical tools; procedures to assure safety and control of cross contamination; consistent biological transition of vaccines from the research laboratory to manufacturing scale; whole infectious attenuated organisms, such as live-attenuated and inactivated whole-cell bacterial vaccines and antiviral vaccines using attenuated or inactivated viruses; principles of viral inactivation and the application of these principles to vaccine development; recombinant DNA approaches to produce modern prophylactic vaccines; bacterial subunit, polysaccharide and glycoconjugate vaccines; combination vaccines that contain multiple antigens as well as regulatory requirements and the hurdles of licensure.

Drug Delivery

Author: Binghe Wang
Publisher: John Wiley & Sons
ISBN: 1118833309
Size: 52.88 MB
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Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery

Molekulare Biotechnologie

Author: David Clark
Publisher: Springer-Verlag
ISBN: 3827421896
Size: 37.20 MB
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Grundlage aller biotechnologischen Prozesse sind molekularbiologische und genetische Regelmechanismen. Deshalb behandelt dieses neuartige Lehrbuch beides: die molekularbiologischen Grundlagen und die Anwendungen. Spannend und aktuell werden die Teilgebiete der Biotechnologie und das jeweils erforderliche molekularbiologische Grundwissen beschrieben. Der Bogen wird gespannt von der Nanobiotechnologie über Stoffwechseltechnologie, Genomics und Umweltbiotechnologie bis hin zur Gentherapie.

Innovation In Vaccinology

Author: Selene Baschieri
Publisher: Springer Science & Business Media
ISBN: 9400745435
Size: 48.43 MB
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Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.

In Silico Immunology

Author: Darren D.R. Flower
Publisher: Springer Science & Business Media
ISBN: 0387392416
Size: 68.82 MB
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This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.