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Introduction To Proteomics

Author: Daniel Liebler
Publisher: Springer Science & Business Media
ISBN: 9780896039919
Size: 17.40 MB
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Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

Recent Advances In Pediatrics 21 Hot Topics

Author: Suraj Gupte
Publisher: JP Medical Ltd
ISBN: 9350257742
Size: 28.99 MB
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Volume 21 of Recent Advances in Pediatrics is a compilation of reviews bringing trainees and physicians fully up to date with key developments in the field. Topics in this new volume include advances in neonatology, nutrition, gastroenterology and hepatology, psychiatry, endocrinology and critical care. Separate chapters are dedicated to vaccines and pharmacotherapy. Presented in an easy to follow format, Volume 21 follows a multidisciplinary approach. Each chapter finishes with a summary of key learning points and extensive references for further reading. Clinical photographs, illustrations and tables enhance learning. Key points New, updated volume presenting latest developments in paediatrics Multidisciplinary approach, easy to follow format Extensive references and key learning points summarised in each chapter Hot Topics Volume 20 published in 2011

Genome Transcriptome And Proteome Analysis

Author: Alain Bernot
Publisher: John Wiley & Sons
ISBN: 0470020792
Size: 31.81 MB
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Genome Transcriptome and Proteome Analysis is a concise introduction to the subject, successfully bringing together these three key areas of research. Starting with a revision of molecular genetics the book offers clear explanations of the tools and techniques widely used in genome, transcriptome and proteome analysis. Subsequent chapters offer a broad overview of linkage maps, physical maps and genome sequencing, with a final discussion on the identification of genes responsible for disease. An invaluable introduction to the basic concepts of the subject, this text offers the student an excellent overview of current research methods and applications and is a good starting point for those new to the area. A clear, concise introduction to the subject of modern genomic analysis A technology-oriented approach including the latest developments in the field Invaluable to those students taking courses in Bioinformatics, Human Genetics, Biochemistry and Molecular Biology

Handbook Of Pharmaceutical Biotechnology

Author: Shayne C. Gad
Publisher: Wiley-Interscience
Size: 46.62 MB
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Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Introduction To Digital Signal Processing And Filter Design

Author: B. A. Shenoi
Publisher: Wiley-Interscience
ISBN: 9780471654421
Size: 32.62 MB
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A practical and accessible guide to understanding digital signal processing Introduction to Digital Signal Processing and Filter Design was developed and fine-tuned from the author's twenty-five years of experience teaching classes in digital signal processing. Following a step-by-step approach, students and professionals quickly master the fundamental concepts and applications of discrete-time signals and systems as well as the synthesis of these systems to meet specifications in the time and frequency domains. Striking the right balance between mathematical derivations and theory, the book features: * Discrete-time signals and systems * Linear difference equations * Solutions by recursive algorithms * Convolution * Time and frequency domain analysis * Discrete Fourier series * Design of FIR and IIR filters * Practical methods for hardware implementation A unique feature of this book is a complete chapter on the use of a MATLAB(r) tool, known as the FDA (Filter Design and Analysis) tool, to investigate the effect of finite word length and different formats of quantization, different realization structures, and different methods for filter design. This chapter contains material of practical importance that is not found in many books used in academic courses. It introduces students in digital signal processing to what they need to know to design digital systems using DSP chips currently available from industry. With its unique, classroom-tested approach, Introduction to Digital Signal Processing and Filter Design is the ideal text for students in electrical and electronic engineering, computer science, and applied mathematics, and an accessible introduction or refresher for engineers and scientists in the field. An Instructor's Manual presenting detailed solutions to all the problems in the book is available online from the Wiley editorial department. An Instructor Support FTP site is also available.

Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents

Author: Vito G. DelVecchio
Publisher: IOS Press
ISBN: 9781586033439
Size: 41.41 MB
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Recent scientific breakthroughs have improved our understanding of the impact of environmental toxic substances on human health. With the knowledge, new techniques are incorporated into human monitoring programs to identify damage to DNA, other macromolecules and cells that can be used to predict health risk from exposure to environmental genotoxic agents. The molecular and cellular responses are often measured in peripheral lymphocytes because these cells can be collected in a socially and ethically acceptable manner, and via a minimally invasive route. However, other cells such as sperm, buccal or nasal epithelial cells, placental cells, and body fluids such as urine and serum, are also used. From these investigations, it becomes obvious that an individual's genetic constitution and lifestyle activities can significantly influence the exposure effect. Genetic constitution includes inherited variations in genes for chemical metabolism and DNA repair. Lifestyle activities include diet and levels of physical activity. Because of the significant influence of the environmental factors on human health, there is increased interest in monitoring human populations for improvement of health. The major objective of this publication is to enhance the knowledge and expertise of researchers in molecular epidemiology and human monitoring.

Proteomics In Cancer Research

Author: Daniel C. Liebler
Publisher: Wiley-Liss
ISBN: 9780471444756
Size: 15.40 MB
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Proteomics in Cancer Research Edited by Daniel C. Liebler Proteomics in Cancer Research covers both the basic principles of proteomics along with detailed presentations of new and emerging technology that represent promising breakthroughs in cancer prevention and treatment. The topics covered include: Basic concepts, including setting up a proteomics laboratory, mass spectrometry, protein separations, protein array technologies, and informatics tools Application of emerging technologies, to proteomic analysis of cancer cells and tissues, including discussion of critical issues such as characteristics of cancer cell proteomes and protein-protein interactions Application of proteomics approaches in clinical cancer research and a forecast of future research and applications In most cases, applications of methods in basic and translational cancer research that are discussed in the text represent the first uses of these proteomics approaches to study any disease. Critical issues that readers in cancer research need to understand are covered in detail, including: Advantages and limitations of different technologies New approaches to the molecular classification of tumors Discovery of new biomarkers and imaging targets and development of new proteomic platforms for profiling and screening The unique proteomic features that characterize cancers offer new opportunities for disease prevention and treatment. Despite intense interest, however, proteomics is just beginning to become a part of the cancer research mainstream, as relatively few cancer researchers have training in proteomics methods and approaches. This book, therefore, is both a timely and an essential guide that will help readers understand key concepts of proteomics and use its methods to search for ways to both cure and prevent cancer.