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Introduction To Statistical Methods For Clinical Trials

Author: Thomas D. Cook
Publisher: CRC Press
ISBN: 1584880279
Size: 44.86 MB
Format: PDF
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Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.

Introduction To General And Generalized Linear Models

Author: Henrik Madsen
Publisher: CRC Press
ISBN: 1439891141
Size: 53.19 MB
Format: PDF, ePub
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Bridging the gap between theory and practice for modern statistical model building, Introduction to General and Generalized Linear Models presents likelihood-based techniques for statistical modelling using various types of data. Implementations using R are provided throughout the text, although other software packages are also discussed. Numerous examples show how the problems are solved with R. After describing the necessary likelihood theory, the book covers both general and generalized linear models using the same likelihood-based methods. It presents the corresponding/parallel results for the general linear models first, since they are easier to understand and often more well known. The authors then explore random effects and mixed effects in a Gaussian context. They also introduce non-Gaussian hierarchical models that are members of the exponential family of distributions. Each chapter contains examples and guidelines for solving the problems via R. Providing a flexible framework for data analysis and model building, this text focuses on the statistical methods and models that can help predict the expected value of an outcome, dependent, or response variable. It offers a sound introduction to general and generalized linear models using the popular and powerful likelihood techniques. Ancillary materials are available at www.imm.dtu.dk/~hm/GLM

Bayesian Methods For Data Analysis Third Edition

Author: Bradley P. Carlin
Publisher: CRC Press
ISBN: 9781584886983
Size: 58.56 MB
Format: PDF, Kindle
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Broadening its scope to nonstatisticians, Bayesian Methods for Data Analysis, Third Edition provides an accessible introduction to the foundations and applications of Bayesian analysis. Along with a complete reorganization of the material, this edition concentrates more on hierarchical Bayesian modeling as implemented via Markov chain Monte Carlo (MCMC) methods and related data analytic techniques. New to the Third Edition New data examples, corresponding R and WinBUGS code, and homework problems Explicit descriptions and illustrations of hierarchical modeling—now commonplace in Bayesian data analysis A new chapter on Bayesian design that emphasizes Bayesian clinical trials A completely revised and expanded section on ranking and histogram estimation A new case study on infectious disease modeling and the 1918 flu epidemic A solutions manual for qualifying instructors that contains solutions, computer code, and associated output for every homework problem—available both electronically and in print Ideal for Anyone Performing Statistical Analyses Focusing on applications from biostatistics, epidemiology, and medicine, this text builds on the popularity of its predecessors by making it suitable for even more practitioners and students.

Stochastic Modeling And Mathematical Statistics

Author: Francisco J. Samaniego
Publisher: CRC Press
ISBN: 1466560479
Size: 24.21 MB
Format: PDF, Mobi
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Provides a Solid Foundation for Statistical Modeling and Inference and Demonstrates Its Breadth of Applicability Stochastic Modeling and Mathematical Statistics: A Text for Statisticians and Quantitative Scientists addresses core issues in post-calculus probability and statistics in a way that is useful for statistics and mathematics majors as well as students in the quantitative sciences. The book’s conversational tone, which provides the mathematical justification behind widely used statistical methods in a reader-friendly manner, and the book’s many examples, tutorials, exercises and problems for solution, together constitute an effective resource that students can read and learn from and instructors can count on as a worthy complement to their lectures. Using classroom-tested approaches that engage students in active learning, the text offers instructors the flexibility to control the mathematical level of their course. It contains the mathematical detail that is expected in a course for "majors" but is written in a way that emphasizes the intuitive content in statistical theory and the way theoretical results are used in practice. More than 1000 exercises and problems at varying levels of difficulty and with a broad range of topical focus give instructors many options in assigning homework and provide students with many problems on which to practice and from which to learn.

Introduction To Randomized Controlled Clinical Trials Second Edition

Author: J. N. S. Matthews
Publisher: St. Martin's Press
ISBN: 9781584886242
Size: 24.60 MB
Format: PDF, Mobi
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Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as cross-over trials, cluster-randomized designs, and equivalence studies. This latest edition features new and revised references, examples, exercises, and a new chapter dedicated to binary outcomes and survival analysis. It also presents numerous examples taken from the medical literature, contains exercises at the end of each chapter, and offers solutions in an appendix. The author uses Minitab and R software throughout the text for implementing the methods that are presented. Comprehensive and accessible, Introduction to Randomized Controlled Clinical Trials is well-suited for those familiar with elementary statistical ideas and methods who want to further their knowledge of the subject.

Introduction To Randomized Controlled Clinical Trials Second Edition

Author: John N.S. Matthews
Publisher: CRC Press
ISBN: 1420011308
Size: 39.74 MB
Format: PDF, ePub
View: 2476
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Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as cross-over trials, cluster-randomized designs, and equivalence studies. This latest edition features new and revised references, examples, exercises, and a new chapter dedicated to binary outcomes and survival analysis. It also presents numerous examples taken from the medical literature, contains exercises at the end of each chapter, and offers solutions in an appendix. The author uses Minitab and R software throughout the text for implementing the methods that are presented. Comprehensive and accessible, Introduction to Randomized Controlled Clinical Trials is well-suited for those familiar with elementary statistical ideas and methods who want to further their knowledge of the subject.

Introduction To Statistical Process Control

Author: Peihua Qiu
Publisher: CRC Press
ISBN: 1439847991
Size: 18.22 MB
Format: PDF, Kindle
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A major tool for quality control and management, statistical process control (SPC) monitors sequential processes, such as production lines and Internet traffic, to ensure that they work stably and satisfactorily. Along with covering traditional methods, Introduction to Statistical Process Control describes many recent SPC methods that improve upon the more established techniques. The author—a leading researcher on SPC—shows how these methods can handle new applications. After exploring the role of SPC and other statistical methods in quality control and management, the book covers basic statistical concepts and methods useful in SPC. It then systematically describes traditional SPC charts, including the Shewhart, CUSUM, and EWMA charts, as well as recent control charts based on change-point detection and fundamental multivariate SPC charts under the normality assumption. The text also introduces novel univariate and multivariate control charts for cases when the normality assumption is invalid and discusses control charts for profile monitoring. All computations in the examples are solved using R, with R functions and datasets available for download on the author’s website. Offering a systematic description of both traditional and newer SPC methods, this book is ideal as a primary textbook for a one-semester course in disciplines concerned with process quality control, such as statistics, industrial and systems engineering, and management sciences. It can also be used as a supplemental textbook for courses on quality improvement and system management. In addition, the book provides researchers with many useful, recent research results on SPC and gives quality control practitioners helpful guidelines on implementing up-to-date SPC techniques.

Statistics In The Pharmaceutical Industry 3rd Edition

Author: Charles Ralph Buncher
Publisher: CRC Press
ISBN: 9780824790738
Size: 35.28 MB
Format: PDF, Mobi
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This rewritten and updated second edition provides comprehensive information on the wide-ranging applications of statistics in the pharmacological field. Focusing on practical aspects, it sets out to bridge the gap between industry and academia.;Reflecting the changes that have taken place since publication of the first edition, this volume covers new topics such as: cancer clinical trials, clinical trials of AIDS patients and animal tumorigenicity studies; the development of antiepileptic drugs; the role of epidemiology in postmarketing trials and adverse drug experience; computer-assisted new drug application (CANDA) submissions; contract research organizations; interim analysis in clinical trials; and room-temperature tests for the stability of drugs.;This work is intended as: a reference for statisticians, biostatisticians, pharmacologists, administrators, managers, and scientists in the pharmaceutical industry; and a text for graduate students taking courses in applied statistics or pharmaceutical statistics.

Introduction To Statistics For Biology

Author: Robin H. McCleery
Publisher: Chapman & Hall
ISBN: 9781584886525
Size: 55.10 MB
Format: PDF, Mobi
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Introduction to Statistics for Biology, Third Edition provides straightforward coverage of the design and analysis of experiments and surveys in biology. The book contains practical, nontechnical advice on carrying out successful projects and producing clear, informative reports.

Introduction To Probability With R

Author: Kenneth Baclawski
Publisher: Chapman and Hall/CRC
ISBN: 9781420065213
Size: 25.28 MB
Format: PDF
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Based on a popular course taught by the late Gian-Carlo Rota of MIT, with many new topics covered as well, Introduction to Probability with R presents R programs and animations to provide an intuitive yet rigorous understanding of how to model natural phenomena from a probabilistic point of view. Although the R programs are small in length, they are just as sophisticated and powerful as longer programs in other languages. This brevity makes it easy for students to become proficient in R. This calculus-based introduction organizes the material around key themes. One of the most important themes centers on viewing probability as a way to look at the world, helping students think and reason probabilistically. The text also shows how to combine and link stochastic processes to form more complex processes that are better models of natural phenomena. In addition, it presents a unified treatment of transforms, such as Laplace, Fourier, and z; the foundations of fundamental stochastic processes using entropy and information; and an introduction to Markov chains from various viewpoints. Each chapter includes a short biographical note about a contributor to probability theory, exercises, and selected answers. The book has an accompanying website with more information.