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Kidney Development Disease Repair And Regeneration

Author: Melissa Helen Little
Publisher: Academic Press
ISBN: 012800438X
Size: 58.97 MB
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Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Kidney Development And Disease

Author: Rachel K. Miller
Publisher: Springer
ISBN: 3319514369
Size: 76.14 MB
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Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Regenerative Nephrology

Author: Michael S. Goligorsky
Publisher: Academic Press
ISBN: 9780123809292
Size: 69.53 MB
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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Kidney Transplantation Bioengineering And Regeneration

Author: Giuseppe Orlando
Publisher: Academic Press
ISBN: 0128018364
Size: 73.87 MB
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Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Animal Models For The Study Of Human Disease

Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0128096993
Size: 17.28 MB
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Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Essays On Developmental Biology

Author: Paul M Wassarman
Publisher: Academic Press
ISBN: 0128016167
Size: 79.41 MB
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In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman

Factors Influencing Mammalian Kidney Development Implications For Health In Adult Life

Author: Karen Moritz
Publisher: Springer Science & Business Media
ISBN: 9783540777687
Size: 34.28 MB
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In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

Mediale Medizin

Author: Anthony William
Publisher: Arkana
ISBN: 3641183901
Size: 28.91 MB
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Seit seiner Kindheit besitzt Anthony William eine einzigartige Gabe: Ein göttlicher Geist flüstert ihm äußerst präzise Informationen zum Gesundheitszustand seiner Mitmenschen ins Ohr. Diese medialen Botschaften zeigen nicht nur, an welcher Krankheit der Betroffene leidet, sondern auch, wie er wieder vollständig gesund wird – und sind dem heutigen Stand der Medizin oft um Lichtjahre voraus. Dieses Buch enthält erstmals das revolutionäre Heilwissen, das sich Anthony William in seiner langjährigen, erfolgreichen Praxis als medizinisches Medium erwarb. Es zeigt die wahren Ursachen von Krankheiten, die in der Medizinwissenschaft als chronisch oder unheilbar gelten, wie beispielsweise Rheumatoide Arthritis, Multiple Sklerose, Typ-2-Diabetes, hormonelle Erkrankungen, chronisches Müdigkeitssyndrom oder Borreliose. Neben der Ursache benennt William einfache, leicht gangbare Wege der Heilung: Detox, Superfoods, Ernährungstipps und eine reinigende 28-tägige Heilkur.

Fundamentals Of Inflammation

Author: Charles N. Serhan
Publisher: Cambridge University Press
ISBN: 1139936670
Size: 64.60 MB
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The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Examination Paediatrics

Author: Wayne Harris
Publisher: Elsevier Health Sciences
ISBN: 0729579409
Size: 15.29 MB
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A practical study guide to help candidates pass clinical examinations in paediatrics, particularly at postgraduate level Examination Paediatrics, 4th Edition is written for candidates preparing for the Fellowship Examination of the Royal Australasian College of Physicians (FRACP). This includes both Australian and New Zealand candidates as well as candidates taking the Australian examination in other countries. This invaluable paediatric study guide is also aimed at candidates preparing for the Membership Examination for the Royal College of Paediatrics and Child Health (UK) (Part II) (MRCPCH). Additionally, Examination Paediatrics will be a useful medical reference for all undergraduate and postgraduate students preparing for any paediatric exam with a clinical component – including those with an OSCE format. The new sections and expanded text in this fourth edition will assist General Practitioners, paediatric residents, house officers, registrars and doctors sitting the Australian Medical Council examination. Examination Paediatrics, 4th Edition contains ample information on history-taking, examination procedure, relevant investigations, memory aids, lists and mnemonics, and management for the majority of chronic paediatric clinical problems seen in hospital-based practice. This new edition retains a key feature popular in previous editions of Examination Paediatrics – a detailed explanation of the attitudinal skills, body language, and motivation necessary to complete clinical examinations successfully. • discussion of new mini CEX (Clinical Evaluation Exercises) and new short case introduction • expanded cardiology, endocrinology and neurology sections with new diagrams • a new section on Williams syndrome • expanded sections on Marfan syndrome and Noonan syndrome • a new long case on obstructive sleep apnoea • a new short case on virilisation