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Life S Greatest Secret

Author: Matthew Cobb
Publisher: Basic Books
ISBN: 0465062660
Size: 36.34 MB
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Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life’s secrets. Life’s Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life’s) future. Life’s Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters—mathematicians, physicists, information theorists, and biologists—who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or “junk DNA” was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb’s telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who’d like to explore those questions for themselves.

Life S Greatest Secret

Author: Matthew Cobb
Publisher: Hachette UK
ISBN: 0465062660
Size: 61.67 MB
Format: PDF, Docs
View: 7497
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Everyone has heard of the story of DNA as the story of Watson and Crick and Rosalind Franklin, but knowing the structure of DNA was only a part of a greater struggle to understand life's secrets. Life's Greatest Secret is the story of the discovery and cracking of the genetic code, the thing that ultimately enables a spiraling molecule to give rise to the life that exists all around us. This great scientific breakthrough has had farreaching consequences for how we understand ourselves and our place in the natural world, and for how we might take control of our (and life's) future. Life's Greatest Secret mixes remarkable insights, theoretical dead-ends, and ingenious experiments with the swift pace of a thriller. From New York to Paris, Cambridge, Massachusetts, to Cambridge, England, and London to Moscow, the greatest discovery of twentieth-century biology was truly a global feat. Biologist and historian of science Matthew Cobb gives the full and rich account of the cooperation and competition between the eccentric characters—mathematicians, physicists, information theorists, and biologists—who contributed to this revolutionary new science. And, while every new discovery was a leap forward for science, Cobb shows how every new answer inevitably led to new questions that were at least as difficult to answer: just ask anyone who had hoped that the successful completion of the Human Genome Project was going to truly yield the book of life, or that a better understanding of epigenetics or “junk DNA” was going to be the final piece of the puzzle. But the setbacks and unexpected discoveries are what make the science exciting, and it is Matthew Cobb's telling that makes them worth reading. This is a riveting story of humans exploring what it is that makes us human and how the world works, and it is essential reading for anyone who'd like to explore those questions for themselves.

Life S Greatest Secret

Author: Matthew Cobb
Publisher: Profile Books
ISBN: 1782830022
Size: 51.28 MB
Format: PDF
View: 175
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Life's Greatest Secret is the story of the discovery and cracking of the genetic code. This great scientific breakthrough has had far-reaching consequences for how we understand ourselves and our place in the natural world. The code forms the most striking proof of Darwin's hypothesis that all organisms are related, holds tremendous promise for improving human well-being, and has transformed the way we think about life. Matthew Cobb interweaves science, biography and anecdote in a book that mixes remarkable insights, theoretical dead-ends and ingenious experiments with the pace of a thriller. He describes cooperation and competition among some of the twentieth century's most outstanding and eccentric minds, moves between biology, physics and chemistry, and shows the part played by computing and cybernetics. The story spans the globe, from Cambridge MA to Cambridge UK, New York to Paris, London to Moscow. It is both thrilling science and a fascinating story about how science is done.

Who Wrote The Book Of Life

Author: Lily E. Kay
Publisher: Stanford University Press
ISBN: 9780804734172
Size: 69.88 MB
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This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. Kay draws out the historical specificity in the process by which the central biological problem of DNA-based protein synthesis came to be metaphorically represented as an information code and a writing technology—and consequently as a “book of life.” This molecular writing and reading is part of the cultural production of the Nuclear Age, its power amplified by the centuries-old theistic resonance of the “book of life” metaphor. Yet, as the author points out, these are just metaphors: analogies, not ontologies. Necessary and productive as they have been, they have their epistemological limitations. Deploying analyses of language, cryptology, and information theory, the author persuasively argues that, technically speaking, the genetic code is not a code, DNA is not a language, and the genome is not an information system (objections voiced by experts as early as the 1950s). Thus her historical reconstruction and analyses also serve as a critique of the new genomic biopower. Genomic textuality has become a fact of life, a metaphor literalized, she claims, as human genome projects promise new levels of control over life through the meta-level of information: control of the word (the DNA sequences) and its editing and rewriting. But the author shows how the humbling limits of these scriptural metaphors also pose a challenge to the textual and material mastery of the genomic “book of life.”

Cracking The Genome

Author: Kevin Davies
Publisher: JHU Press
ISBN: 9780801871405
Size: 40.14 MB
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This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.

The Least Likely Man

Author: Franklin H. Portugal
Publisher: MIT Press
ISBN: 0262028476
Size: 22.17 MB
Format: PDF, Kindle
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How unassuming government researcher Marshall Nirenberg beat James Watson, Francis Crick, and other world-famous scientists in the race to discover the genetic code.

Gene Machine

Author: Venki Ramakrishnan
Publisher: Basic Books
ISBN: 046509337X
Size: 16.55 MB
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A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."--Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

Generation

Author: Matthew Cobb
Publisher: Bloomsbury Publishing USA
ISBN: 9781608190010
Size: 39.92 MB
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Generation is the story of the exciting, largely forgotten decade during the seventeenth century when a group of young scientists-Jan Swammerdam, the son of a Protestant apothecary, Nils Stensen (also known as Steno), a Danish anatomist who first discovered the human tear duct, Reinier de Graaf, the attractive and brilliant son of a rich and successful Catholic architect, and Antoni Leeuwenhoek, a self-taught draper-dared to challenge thousands of years of orthodox thinking about where life comes from. By meticulous experimentation, dissection, and observation with the newly invented microscope, they showed that like breeds like, that all animals come from an egg, that there is no such thing as spontaneous generation, and that there are millions of tiny, wriggling "eels" in semen. However, their ultimate inability to fully understand the evidence that was in front of them led to a fatal mistake. As a result, the final leap in describing the process of reproduction-which would ultimately give birth to the science of genetics-took nearly two centuries for humanity to achieve. Including previously untranslated documents, Generation interweaves the personal stories of these scientists against a backdrop of the Dutch "Golden Age." It is a riveting account of the audacious men who swept away old certainties and provided the foundation for much of our current understanding of the living world.

A History Of Molecular Biology

Author: Michel Morange
Publisher: Harvard University Press
ISBN: 9780674001695
Size: 43.34 MB
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Gene therapy, the human genome project, the creation of new varieties of animals and plants have all emanated from molecular biology. Beginning with turn-of-the-century experimentations, this ambitious history covers the story of the transformation of biology over the last 100 years.

In Search Of Schrodinger S Cat

Author: John Gribbin
Publisher: Bantam
ISBN: 9780307790446
Size: 30.39 MB
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Quantum theory is so shocking that Einstein could not bring himself to accept it. It is so important that it provides the fundamental underpinning of all modern sciences. Without it, we'd have no nuclear power or nuclear weapons, no TV, no computers, no science of molecular biology, no understanding of DNA, no genetic engineering. In Search of Schrodinger's Cat tells the complete story of quantum mechanics, a truth stranger than any fiction. John Gribbin takes us step by step into an ever more bizarre and fascinating place, requiring only that we approach it with an open mind. He introduces the scientists who developed quantum theory. He investigates the atom, radiation, time travel, the birth of the universe, superconductors and life itself. And in a world full of its own delights, mysteries and surprises, he searches for Schrodinger's Cat - a search for quantum reality - as he brings every reader to a clear understanding of the most important area of scientific study today - quantum physics. In Search of Schrodinger's Cat is a fascinating and delightful introduction to the strange world of the quantum - an essential element in understanding today's world. From the Trade Paperback edition.