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Mechanosensing And Mechanochemical Transduction In Extracellular Matrix

Author: Frederick H. Silver
Publisher: Springer Science & Business Media
ISBN: 0387281762
Size: 46.12 MB
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This is the only single authored text on biological polymers available for bioengineering and biomedical engineering students. The book describes the structure of polymers and how these molecules are put together to make the tissues of the body and also their role in surgical implants and in structural diseases. It provides essential reading for biomedical engineers, biologists, physicians, health care professionals and other biomedical researchers who are interested in understanding how physical forces affect the biology, physiology and pathophysiology of humans. The author is an expert on the effect of mechanical forces on extracellular matrix.

Scaffolds For Tissue Engineering

Author: Claudio Migliaresi
Publisher: CRC Press
ISBN: 9814463213
Size: 45.30 MB
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Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are derived from already well-established industrial processes, with some new specific technologies having been developed in the last years to address required complexities. Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of scaffolds from a physical and biological point of view. The book illustrates scaffold design principles, with particular relevance to the biological requirements needed to control and drive the biological cross talk, and reviews materials and fabrication and validation methods.

Cell Mechanics

Author: Arnaud Chauvière
Publisher: CRC Press
ISBN: 9781420094558
Size: 77.23 MB
Format: PDF, ePub
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Ubiquitous and fundamental in cell mechanics, multiscale problems can arise in the growth of tumors, embryogenesis, tissue engineering, and more. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling brings together new insight and research on mechanical, mathematical, physical, and biological approaches for simulating the behavior of cells, specifically tumor cells. In the first part of the text, the book discusses the powerful tool of microrheology for investigating cell mechanical properties, multiphysics and multiscale approaches for studying intracellular mechanisms in cell motility, and the role of subcellular effects involving certain genes for inducing cell motility in cancer. Focusing on models based on physical, mathematical, and computational approaches, the second section develops tools for describing the complex interplay of cell adhesion molecules and the dynamic evolution of the cell cytoskeleton. The third part explores cell interactions with the environment, particularly the role of external mechanical forces and their effects on cell behavior. The final part presents innovative models of multicellular systems for developmental biology, cancer, and embryogenesis. This book collects novel methods to apply to cells and tissues through a multiscale approach. It presents numerous existing tools while stimulating the discovery of new approaches that can lead to more effective and accurate predictions of pathologies.


Author: Peter Fratzl
Publisher: Springer Science & Business Media
ISBN: 9780387739069
Size: 78.21 MB
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Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Mathematik Und Technologie

Author: Christiane Rousseau
Publisher: Springer-Verlag
ISBN: 3642300928
Size: 34.56 MB
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Zusammen mit der Abstraktion ist die Mathematik das entscheidende Werkzeug für technologische Innovationen. Das Buch bietet eine Einführung in zahlreiche Anwendungen der Mathematik auf dem Gebiet der Technologie. Meist werden moderne Anwendungen dargestellt, die heute zum Alltag gehören. Die mathematischen Grundlagen für technologische Anwendungen sind dabei relativ elementar, was die Leistungsstärke der mathematischen Modellbildung und der mathematischen Hilfsmittel beweist. Mit zahlreichen originellen Übungen am Ende eines jeden Kapitels.

Kosmische Kollisionen

Author: Lars Lindberg Christensen
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827425553
Size: 16.15 MB
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Kollidierende Galaxien bieten faszinierende Bilder am Himmel, wenn sie mit dem hochauflösenden Hubble-Weltraumteleskop beobachtet werden. Dieser Bildband dreier ESO-Spezialisten aus dem Hubble-Team von NASA und ESA enthält spektakuläre Astroaufnahmen, die illustrieren, wie die Gravitation die Massenbewegungen im Kosmos orchestriert – und ganze Galaxien ineinander stürzen lässt. Diese gewaltigen kosmischen Kollisionen könnten die Struktur unseres heutigen Universums maßgeblich beeinflusst haben, indem sie die Energie lieferten, die neue Sterne entstehen ließ.