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Methods Of Non Amino Acid Synthesis Second Edition

Author: Michael Bryant Smith
Publisher: CRC Press
ISBN: 1466577894
Size: 55.96 MB
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Although less common than α-amino acids, non-α-amino acids—where the amino group is not on the carbon immediately adjacent to the carboxyl group but is attached to another carbon in the chain (for example, the β, γ, δ carbon)—are components of biologically important molecules, are significant in the pharmaceutical industry, and are useful starting materials for many areas of organic chemistry. Since the publication of the first edition of this book nearly 20 years ago, synthetic work devoted to the preparation of non- α-amino acids has expanded greatly. Methods of Non-α-Amino Acid Synthesis, Second Edition has been extensively rewritten and reorganized, providing an up-to-date review of strategies and methods for non-α-amino acid synthesis, particularly those amino acids that are key synthetic intermediates or important compounds in their own right. It focuses on acyclic amino acids of C3–C10, but also aminoalkanoic carboxylic acids, aminoalkenoic acids, and aminoalkynoic acids. The new edition contains many updated references and has a greater emphasis on the biological importance of non-α-amino acids. In addition to an array of synthetic methods, the book offers discussions on why non-α-amino acids are important. The book covers synthetic methods that rely on substituent refunctionalization, the conversion of cyclic precursors to acyclic amino acids, conjugate addition reactions, and enolate anion reactions and condensation reactions that lead to non-α-amino acids. It also examines reactions and strategies that lead to good diastereoselectivity and enantioselectivity during synthesis. A chapter devoted to biologically important amino acids includes separate sections on GABA, GABOB, carnitine, DAVA, statine, and other significant amino acids as well as a new section on peptides and proteins that contain non-α-amino acids. The final chapter addresses aminocyclic and heterocyclic amino acids.

Enantioselective Synthesis Of Beta Amino Acids

Author: Eusebio Juaristi
Publisher: John Wiley & Sons
ISBN: 0471698474
Size: 76.96 MB
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Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature publishedon the subject, interest in ß-amino acids has grown over thepast several years. With major pharmaceutical applications, theseamino acids are now studied across multiple lines of research,including combinatorial chemistry, medicinal chemistry, moleculardesign, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-AminoAcids updates reviews included in the First Edition while alsocovering new developments since its publication. The book presentsdetailed discussions of the most important methods for thesynthesis of ß-amino acids. In most cases, the lead chemistwho originally developed a method provides an authoritativedescription of it. In addition, Enantioselective Synthesis of ß-Amino Acids,Second Edition: * Features introductory overviews on the structural types ofrelevant ß-amino acid targets and salient ß-amino acidspresent in natural products * Dedicates several chapters to advances in the synthesis ofoligomers from ß-amino acids * Includes general and practical procedures for the preparation ofß-amino acids in each chapter * Discusses the most important methods that have been recentlydeveloped for the asymmetric synthesis of cyclic and open-chainß-amino acids * Includes a report on the preparation of libraries of enantiopureß-amino acids using combinatorial approaches The only book of its kind available today, EnantioselectiveSynthesis of ß-Amino Acids, Second Edition offers upper-levelstudents and professionals an essential resource for pharmaceuticaldevelopment, medicinal chemistry, and biochemistry.

Pharmaceutical Formulation Development Of Peptides And Proteins Second Edition

Author: Lars Hovgaard
Publisher: CRC Press
ISBN: 1439853886
Size: 46.88 MB
Format: PDF, Kindle
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The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses: The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response A simulation approach to describe the fate of peptides and proteins upon administration to a biological system The documentation required to register a protein-based drug Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.

Analytical And Instrumental Techniques In Agriculture Environmental And Food Engineering Second Edition

Author: NAG, A.
Publisher: PHI Learning Pvt. Ltd.
ISBN: 8120351185
Size: 71.45 MB
Format: PDF, ePub
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The book, in its second edition, discusses the methodology usually adopted to determine different types of parameters necessary for the design, analysis and monitoring of various activities in agricultural and environmental engineering. With the advancement in the food science, the development of concepts for analysis, techniques and instrumentation has become essential for the field of food engineering. Thus, the text includes different experiments and instrumentation techniques for analysis of food and its preservation in an easy-to-follow style for the students, researchers, practicing engineers and food industrialists, besides agricultural and environmental engineering. The text also describes in detail modern instrumental techniques such as Chromatographic methods, IR, UV, NMR, Mass spectroscopy, Circular dichroism, Thermogravimetric analysis and gives many solved problems based on those instruments. The compact and concise book dealing with different analytical and instrumental techniques used in agriculture, environmental and food engineering is of immense value to undergraduate and postgraduate students in these disciplines as well as for the researchers. FEATURES OF THE NEW EDITION 1. Different experiments for analysis of food and its preservation have been incorporated for helping students of food engineering which reflects in the title of the book. 2. Different types of instrumental techniques such as NMR, Flame Photometry, Circular Dichroism and Thermogravimetric analysis have been added in the chapter on Instrumental Techniques so that the students and researchers of different branches are benefited from the book. 3. Solved problems have been provided to strengthen students’ skills in solving numerical problems.

Fermentation Microbiology And Biotechnology Second Edition

Author: E. M. T. El-Mansi
Publisher: CRC Press
ISBN: 9780849353345
Size: 51.49 MB
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The pace of progress in fermentation microbiology and biotechnology is fast and furious, with new applications being implemented that are resulting in a spectrum of new products, from renewable energy to solvents and pharmaceuticals Fermentation Microbiology and Biotechnology, Second Edition builds on the foundation of the original seminal work, extending its reach to reflect the multidisciplinary and expansive nature of fermentation research and advancements. While retaining valuable information from the previous edition including a brief history of the industry, as well as an overview of instrumentation and fermentor design, fermentation kinetics, and flux control analysis, the second edition addresses numerous topics that have risen to prominence in the past few years. New chapters explore the diverse array of microbial biosynthetic pathways currently used by the fermentation and pharmaceutical industries for the production of primary and secondary metabolites such as amino acids, vitamins, antibiotics, immunosuppressants, and anti-tumor agents. The authors also examine recent advances in enzyme and co-factor engineering and cell immobilization with respect to both novel drug development and improved yields from microbial processes. Beyond pharmaceuticals, this volume considers the emerging role of fermentation in the conversion of renewable resources to fine chemicals, as well as its potential use in converting lignocellulosic waste to ethanol. In addition, readers will also discover new chapters devoted to discussions of industrial issues such as modeling and sensor technology, as well as supervision and control in the fermentation process. The text is packed with examples and case studies from the industry, carefully chosen to illuminate and reinforce principles and methodology discussed in the chapters. Organized and written in a concise and lucid manner that requires only a general background in microbiology, this volume meets the needs

Metabolic Therapeutic Aspects Of Amino Acids In Clinical Nutrition Second Edition

Author: Luc A. Cynober
Publisher: CRC Press
ISBN: 9780203010266
Size: 21.57 MB
Format: PDF, ePub
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The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference has fully explored the promising new developments and applications in this key area of clinical nutrition. Completely revised and updated, Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition, Second Edition presents current information and discussions on amino acid metabolism in various health and nutritional states. Chapters cover amino acid uptake routes, physiology, requirements, metabolism, and applications. Written by an international group of experts, the text re-evaluates data and hypotheses in light of the most recent discoveries in genomics and proteomics research. Building on the solid foundation of the original reference, the second edition refines much of the previous information and features the fresh insight and ideas of new authors. These timely additions on the role of amino acids in the future of human health and disease ensure that this book will continue to be a standard resource for researchers in this field.

Amino Acid And Peptide Synthesis

Author: John Jones
Publisher: Oxford University Press, USA
ISBN: 9780199257386
Size: 68.67 MB
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The study of amino acids and peptides is becoming increasingly important to chemists becuase of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis. With its emphasis on chemical principles and strategies rather than detailed technical matters, the book will be essential reading for all students of chemistry and biochemistry with an interest in this important field. This second edition contains extensive additions and adjustments, to present a completely up-to-date account of the chemical essentials of mainstream peptide synthesis.

Structural Aspects Of Protein Synthesis

Author: Mans Ehrenberg
Publisher: World Scientific
ISBN: 9814531804
Size: 29.85 MB
Format: PDF
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This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation. There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.Contents: The Basics of TranslationHistorical MilestonesMethods of Studying StructureThe Message ? mRNAThe Adaptor ? tRNAThe Workbench ? RibosomesThe Structure of the RibosomeRibosomal Sites and Ribosomal StatesThe Catalysts ? Translation FactorsInhibitors of Protein Synthesis ? Antibiotics, ResistanceThe Process ? TranslationProtein Processing, Folding and TargetingEvolution of the Translation Apparatus Readership: Upper level undergraduates and graduate students with an interest in protein synthesis; researchers in cell and molecular biology, biochemistry and biophysics who need to get an overview of translation.

Houben Weyl Methods Of Organic Chemistry Vol E 22c 4th Edition Supplement

Author: Dale L. Boger
Publisher: Georg Thieme Verlag
ISBN: 3131823240
Size: 72.81 MB
Format: PDF, ePub, Docs
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Houben-Weyl is the acclaimed reference series for preparative methods in organic chemistry, in which all methods are organized accor ding to the class of compound or functional group to be synthesized. The Houben-Weyl volumes contain 146 000 product-specific experi mental procedures, 580 000 structures, and 700 000 references. The preparative significance of the methods for all classes of compou nds is critically evaluated. The series includes data from as far back as the early 1800s to 2003. // The content of this e-book was originally published in 2003.