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Modeling In Biopharmaceutics Pharmacokinetics And Pharmacodynamics

Author: Panos Macheras
Publisher: Springer
ISBN: 3319275984
Size: 21.75 MB
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The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that is now being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006)

Mathematical Physiology

Author: James Keener
Publisher: Springer Science & Business Media
ISBN: 9780387793887
Size: 74.37 MB
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Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing. New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included.

From Gestalt Theory To Image Analysis

Author: Agnès Desolneux
Publisher: Springer Science & Business Media
ISBN: 0387726357
Size: 28.77 MB
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This book introduces a new theory in Computer Vision yielding elementary techniques to analyze digital images. These techniques are a mathematical formalization of the Gestalt theory. From the mathematical viewpoint the closest field to it is stochastic geometry, involving basic probability and statistics, in the context of image analysis. The book is mathematically self-contained, needing only basic understanding of probability and calculus. The text includes more than 130 illustrations, and numerous examples based on specific images on which the theory is tested. Detailed exercises at the end of each chapter help the reader develop a firm understanding of the concepts imparted.

Signale Prozesse Systeme

Author: Ulrich Karrenberg
Publisher: Springer-Verlag
ISBN: 3540273476
Size: 74.35 MB
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Buch und CD-ROM bilden ein Lernsystem, welches selbst erforschendes Lernen und die Visualisierung komplexer Vorgänge möglich macht. Das zugrunde liegende didaktische Konzept setzt auf die Visualisierung von Signalen und Prozessen sowie auf die grafische Programmierung signaltechnischer Systeme.

Verhext In Texas

Author: Shanna Swendson
Publisher: S. Fischer Verlag
ISBN: 3104010005
Size: 10.11 MB
Format: PDF
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Katie Chandler hat das hektische Manhattan verlassen und gegen die Freuden des einfachen Lebens auf dem Land eingetauscht. Sie arbeitet jetzt in der Agrarhandlung ihrer Eltern in Cobb, Texas, mit. Währenddessen versucht der unwiderstehliche Zauberer Owen Palmer, in New York seine übernatürlichen Feinde zu besiegen. Selbstlos hat Katie edlen Verzicht geübt, denn sie schien das Böse in Manhattan geradezu anzuziehen, was Owens Job nur schwerer machte. Aber nun scheinen die Probleme Katie nach Hause gefolgt zu sein: Denn obwohl man ihr versichert hatte, dass Cobb völlig frei von Magie sei, bemerkt Katie zunehmend seltsame Vorkommnisse und Erscheinungen. Und nach ihren Erfahrungen in New York erkennt sie faulen Zauber, wenn sie ihn sieht. Als die finsteren Mächte in Texas wirksam werden, schlagen Katie und Owen mit vereinten Kräften zurück und entlarven die Übeltäter, bevor das Böse im Wilden Westen Wurzeln schlagen kann.