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Modelling In Molecular Biology

Author: Gabriel Ciobanu
Publisher: Springer Science & Business Media
ISBN: 364218734X
Size: 44.88 MB
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Presents new mathematical and computational models as well as statistical methods for the solution of fundamental problems in the biosciences. Describes how to find regularities among empirical data, as well as conceptual models and theories.

Applications Of Membrane Computing

Author: Gabriel Ciobanu
Publisher: Springer Science & Business Media
ISBN: 9783540299370
Size: 26.65 MB
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Membrane computing is a branch of natural computing which investigates computing models abstracted from the structure and functioning of living cells and from their interactions in tissues or higher-order biological structures. The models considered, called membrane systems (P systems), are parallel, distributed computing models, processing multisets of symbols in cell-like compartmental architectures. In many applications membrane systems have considerable advantages – among these are their inherently discrete nature, parallelism, transparency, scalability and nondeterminism. In dedicated chapters, leading experts explain most of the applications of membrane computing reported so far, in biology, computer science, computer graphics and linguistics. The book also contains detailed reviews of the software tools used to simulate P systems.

Mobility In Process Calculi And Natural Computing

Author: Bogdan Aman
Publisher: Springer Science & Business Media
ISBN: 3642248675
Size: 22.40 MB
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The design of formal calculi in which fundamental concepts underlying interactive systems can be described and studied has been a central theme of theoretical computer science in recent decades, while membrane computing, a rule-based formalism inspired by biological cells, is a more recent field that belongs to the general area of natural computing. This is the first book to establish a link between these two research directions while treating mobility as the central topic. In the first chapter the authors offer a formal description of mobility in process calculi, noting the entities that move: links (π-calculus), ambients (ambient calculi) and branes (brane calculi). In the second chapter they study mobility in the framework of natural computing. The authors define several systems of mobile membranes in which the movement inside a spatial structure is provided by rules inspired by endocytosis and exocytosis. They study their computational power in comparison with the classical notion of Turing computability and their efficiency in algorithmically solving hard problems in polynomial time. The final chapter deals with encodings, establishing links between process calculi and membrane computing so that researchers can share techniques between these fields. The book is suitable for computer scientists working in concurrency and in biologically inspired formalisms, and also for mathematically inclined scientists interested in formalizing moving agents and biological phenomena. The text is supported with examples and exercises, so it can also be used for courses on these topics.

Nanotechnology Science And Computation

Author: Junghuei Chen
Publisher: Springer Science & Business Media
ISBN: 3540302964
Size: 46.83 MB
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Nanoscale science and computing is becoming a major research area as today's scientists try to understand the processes of natural and biomolecular computing. The field is concerned with the architectures and design of molecular self-assembly, nanostructures and molecular devices, and with understanding and exploiting the computational processes of biomolecules in nature. This book offers a unique and authoritative perspective on current research in nanoscale science, engineering and computing. Leading researchers cover the topics of DNA self-assembly in two-dimensional arrays and three-dimensional structures, molecular motors, DNA word design, molecular electronics, gene assembly, surface layer protein assembly, and membrane computing. The book is suitable for academic and industrial scientists and engineers working in nanoscale science, in particular researchers engaged with the idea of computing at a molecular level.

Discrete And Topological Models In Molecular Biology

Author: Nataša Jonoska
Publisher: Springer Science & Business Media
ISBN: 3642401937
Size: 16.69 MB
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Theoretical tools and insights from discrete mathematics, theoretical computer science, and topology now play essential roles in our understanding of vital biomolecular processes. The related methods are now employed in various fields of mathematical biology as instruments to "zoom in" on processes at a molecular level. This book contains expository chapters on how contemporary models from discrete mathematics – in domains such as algebra, combinatorics, and graph and knot theories – can provide perspective on biomolecular problems ranging from data analysis, molecular and gene arrangements and structures, and knotted DNA embeddings via spatial graph models to the dynamics and kinetics of molecular interactions. The contributing authors are among the leading scientists in this field and the book is a reference for researchers in mathematics and theoretical computer science who are engaged with modeling molecular and biological phenomena using discrete methods. It may also serve as a guide and supplement for graduate courses in mathematical biology or bioinformatics, introducing nontraditional aspects of mathematical biology.

Transactions On Computational Systems Biology Iii

Author: Corrado Priami
Publisher: Springer Science & Business Media
ISBN: 9783540308836
Size: 25.43 MB
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In the last few decades, advances in molecular biology and in the research - frastructure in this ?eld has given rise to the "omics" revolution in molecular biology, alongwiththeexplosionofdatabases: fromgenomicstotranscriptomics, proteomics, interactomics, and metabolomics. However, the huge amount of b- logicalinformationavailablehasleftabottleneckindataprocessing: information over?ow has called for innovative techniques for their visualization, modelling, interpretationandanalysis.The manyresultsfromthe ?eldsofcomputerscience andengineeringhavethenmetwithbiology, leadingto new, emergingdisciplines such as bioinformatics and systems biology. So, for instance, as the result of - plicationoftechniquessuchasmachinelearning, self-organizingmaps, statistical algorithms, clusteringalgorithmsandmulti-agentsystemstomodernbiology, we can actually model and simulate some functions of the cell (e.g., protein inter- tion, gene expression and gene regulation), make inferences from the molecular biology database, make connections among biological data, and derive useful predictions. Today, and more generally, two di?erent scenarios characterize the po- genomic era. On the one hand, the huge amount of datasets made available by biological research all over the world mandates for suitable techniques, tools and methods meant at modelling biological processes and analyzing biological sequences. On the other hand, biological systems work as the sources of a wide range of new computational models and paradigms, which are now ready to be applied in the context of computer-based systems.

Biological Modeling And Simulation

Author: Russell Schwartz
Publisher: MIT Press
ISBN: 0262303396
Size: 16.45 MB
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There are many excellent computational biology resources now available for learning about methods that have been developed to address specific biological systems, but comparatively little attention has been paid to training aspiring computational biologists to handle new and unanticipated problems. This text is intended to fill that gap by teaching students how to reason about developing formal mathematical models of biological systems that are amenable to computational analysis. It collects in one place a selection of broadly useful models, algorithms, and theoretical analysis tools normally found scattered among many other disciplines. It thereby gives the aspiring student a bag of tricks that will serve him or her well in modeling problems drawn from numerous subfields of biology. These techniques are taught from the perspective of what the practitioner needs to know to use them effectively, supplemented with references for further reading on more advanced use of each method covered. The text, which grew out of a class taught at Carnegie Mellon University, covers models for optimization, simulation and sampling, and parameter tuning. These topics provide a general framework for learning how to formulate mathematical models of biological systems, what techniques are available to work with these models, and how to fit the models to particular systems. Their application is illustrated by many examples drawn from a variety of biological disciplines and several extended case studies that show how the methods described have been applied to real problems in biology.

Computational Cell Biology

Author: Christopher P. Fall
Publisher: Springer Science & Business Media
ISBN: 0387224599
Size: 10.35 MB
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This textbook provides an introduction to dynamic modeling in molecular cell biology, taking a computational and intuitive approach. Detailed illustrations, examples, and exercises are included throughout the text. Appendices containing mathematical and computational techniques are provided as a reference tool.

Structures In Logic And Computer Science

Author: Jan Mycielski
Publisher: Springer Science & Business Media
ISBN: 9783540632467
Size: 50.29 MB
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The book summarises contemporary knowledge about the theory of atomic and molecular clusters. New results are discussed on a high theoretical level. Access to this field of research is given by an explanation of the various subjects in introductory chapters.