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Molecular Genetics Of Sex Determination

Author: Stephen S. Wachtel
Publisher: Academic Press
ISBN: 1483295583
Size: 50.97 MB
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In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field

Molecular Genetic Mechanisms Of Sex Determination In Animals

Author: Aleksandr F. Smirnov
Publisher: Scientific Research Publishing, Inc. USA
ISBN: 1618963902
Size: 63.27 MB
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Gender (sex) is a set of morphological and physiological characteristics of the organism underlying sexual reproduction, the essence of which is reduced to fertilization, i.e. the fusion of male and female gametes (gametes) zygote, which develops into a new organism.Sexual reproduction of a species is considered as one of the mechanisms of its homeostasis. Thanks to this mechanism, numerous species have an evolutionary advantage. In the book, two authors will discuss the types of genetic sex determination and differentiation, mostly in multicellular animal organisms. Sex determination is both genetic and environmental process, the sex of an individual being established through an alternative physiological solution. There are two main postulated mechanisms of sex determination: genetic (GSD, Genetical Sex Determination) and environmental (ESD, Environmental Sex Determination).

Genetics Of Sex Determination

Author: R.S. Verma
Publisher: Elsevier
ISBN: 9780080526171
Size: 61.22 MB
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The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level. The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.

The Genetics And Biology Of Sex Determination

Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 9780470843468
Size: 64.96 MB
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Nature employs a wide variety of sex determining mechanisms and itis only comparatively recently that the tools have become availablefor these to be explored at the cellular and molecularlevels. A major landmark was the discovery in 1990 of theSRY gene and the subsequent demonstration of its key role intriggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of themolecular genetic pathways of sex determination, with specialemphasis on vertebrates. It features comparisons with othermodes of sex determination, consideration of the biology of sexualdevelopment and discussion of the evolution of sex-determiningmechanisms. By bringing together an international and interdisciplinarygroup of experts who study many different aspects of the problem,the book highlights much new and exciting work in this area andserves to identify and stimulate promising new researchdirections.

Sex Chromosomes And Sex Determination In Vertebrates

Author: Alberto J. Solari
Publisher: CRC Press
ISBN: 9780849345715
Size: 10.45 MB
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The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs. The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.

Insect Molecular Genetics

Author: Marjorie A. Hoy
Publisher: Elsevier
ISBN: 1483293718
Size: 18.20 MB
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Developed as an introduction to new molecular genetic techniques, Insect Molecular Genetics also provides literature, terminology, and additional sources of information to students, researchers, and professional entomologists. Although most molecular genetics studies have employed Drosophila, this book applies the same techniques to other insects, including pest insects of economic importance. As a text, as a reference, as a primer, and as a review of a vast and growing literature, Insect Molecular Genetics is a valuable addition to the libraries of entomologists, geneticists, and molecular biologists. Features offered by this unique reference source: * Detailed illustrations * Suggested readings at the end of each chapter * Glossary of molecular genetic terms

Sex Determination Differentiation And Intersexuality In Placental Mammals

Author: R. H. F. Hunter
Publisher: Cambridge University Press
ISBN: 9780521462181
Size: 68.75 MB
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How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Mllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

Molecular Biology And Biotechnology

Author: Robert A. Meyers
Publisher: John Wiley & Sons
ISBN: 9780471186342
Size: 46.89 MB
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Essential for the top of every desk and laboratory bench, this single volume reference is the first and last resource required to answer any question relating to molecular biology, biotechnology, or molecular medicine. This work contains the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. Over 250 carefully reviewed articles written by 378 eminent scientists in the field, provide detailed and readable coverage of today's most relevant topics including life processes at the molecular level, genetic disease diagnosis and genetic therapy, the theory and techniques for understanding, manipulating, and synthesizing biological molecules and their aggregates.

Sex Determination In Fish

Author: T. J. Pandian
Publisher: CRC Press
ISBN: 1439879192
Size: 60.18 MB
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This book is the first to report that research in allogenics/xenogenics has conclusively shown that fishes have retained bisexual potency even after sexual maturity and spermiation. The XY genotype found in the unexpected female phenotypes sired by supermales (Y1Y2) and androgenic males (Y2Y2) points out the need to employ sex specific molecular markers to identify the true genotype of a juvenile, which matures either as a male or female, depending upon the sex of its pair (female or male) and thereby critically assessing the environmental role in sex determination. This book is meant to assist molecular biologists in the search of sex determining gene(s), fishery biologists endeavouring to develop techniques for profitable monosex aquaculture and ecologists interested in conservation of fishes and their genomes.

Sex Determination In Plants

Author: CC Ainsworth
Publisher: Garland Science
ISBN: 1135325669
Size: 30.29 MB
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Indispensable for all plant biologists, this is a fascinating and thorough examination of those factors which affect the sex determination of plant species, describing all of the main classes of plant with unisexual flowers hermaphrodite, monoecious and