Download molecules to medicine with mtor translating critical pathways into novel therapeutic strategies in pdf or read molecules to medicine with mtor translating critical pathways into novel therapeutic strategies in pdf online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get molecules to medicine with mtor translating critical pathways into novel therapeutic strategies in pdf book now. This site is like a library, Use search box in the widget to get ebook that you want.



Molecules To Medicine With Mtor

Author: Kenneth Maiese
Publisher: Academic Press
ISBN: 012802755X
Size: 27.99 MB
Format: PDF, ePub, Mobi
View: 7204
Download and Read
Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Autophagy And Cardiometabolic Diseases

Author: Jun Ren
Publisher: Academic Press
ISBN: 0128054425
Size: 34.69 MB
Format: PDF, Mobi
View: 7384
Download and Read
Autophagy and Cardiometabolic Diseases: From Moleculer Mechanisms to Translational Medicine covers the science of autophagy in relation to cardiometabolic diseases and the future therapeutic potentials of autophagy regulation in these processes. Processes are not described in isolation, but in concert with other cellular and/or metabolic processes, such as lipogenesis, glucose, energy metabolism and apoptosis. This approach recognizes the multifactorial nature of cardiometabolic diseases, including obesity, diabetes, insulin resistance, hypertension and dyslipidemia. The book provides explanations, while also distinguishing the delicate role for autophagy in pathogenesis and exploring complications for cardiometabolic diseases. By targeting autophagy, it offers new avenues for drug discovery and treatment for cardiometabolic anomalies. It is a perfect resource for cardiology researchers, scientists and medical practitioners. Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases Provides knowledge from internationally recognized contributors in the field Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases Contains access to a companion website with additional illustrations

Renal Cell Carcinoma

Author: Robert A. Figlin
Publisher: Springer Science & Business Media
ISBN: 1461424003
Size: 72.87 MB
Format: PDF, ePub, Mobi
View: 5940
Download and Read
This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.

Rare Lymphomas

Author: Martin Dreyling
Publisher: Springer Science & Business Media
ISBN: 3642395902
Size: 17.15 MB
Format: PDF, ePub, Docs
View: 6935
Download and Read
After a decade of tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma, optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity.

Lung Cancer New Insights For The Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464900140
Size: 58.12 MB
Format: PDF
View: 1426
Download and Read
Lung Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Lung Cancer. The editors have built Lung Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lung Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lung Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Kuerer S Breast Surgical Oncology

Author: Henry Kuerer
Publisher: McGraw Hill Professional
ISBN: 0071601775
Size: 24.66 MB
Format: PDF, Mobi
View: 700
Download and Read
A complete multidisciplinary guide to breast surgical oncology Includes DVD with surgical video clips and breast ultrasound atlas A Doody's Core Title for 2011! A British Medical Association Book Awards Runner-up, Oncology category! "Kuerer's new textbook of Breast Surgical Oncology is a comprehensive volume that contains exceptionally detailed and thorough information about the diverse aspects of breast cancer care, and would serve as a valuable resource for any breast cancer clinician, regardless of their specialty. ... (the book) is easy to read and navigate, where clinicians can quickly obtain reliable, up-to-date information on a broad range of topics relevant to breast cancer. --Annals of Surgery, August 2010 4 STAR DOODY'S REVIEW! "...a comprehensive and authoritative synthesis of current information is sorely needed, and this book fulfills that need admirably....The figures (many in color) and tables reproduce beautifully. The chapters on ultrasound, clinical trials, and plastic surgery, are particularly valuable. This is a terrific and incredibly useful book on breast surgical oncology, and will be an important reference in the field."--Doody's Review Service Written by an internationally recognized multidisciplinary team of authors, Kuerer's Breast Surgical Oncology is the first text specifically dedicated to breast surgical oncology. Turn to any page, and you’ll find cutting-edge, evidence-based information and insights—supplemented by a full-color presentation and a companion DVD—all designed to help provide a solid foundation for current and future best practices. Kuerer's examines all clinically relevant knowledge in the field, from the pathology of the breast and clinical management, to follow-up and complications following diagnosis and therapy. The book also focuses on the next wave of molecular studies that represent the future of the discipline. Features Complete integration of the relevant disease pathology with clinical management Major sections on both oncoplastic and advanced operative management procedures An entire section on landmark breast cancer clinical trials that highlights essential knowledge and evidence in the field Full-color design with 750 illustrations that depict anatomy, breast cancer pathology, and trial results A DVD with surgical video clips that details some of the important surgical techniques and procedures featured in the text An entire section on breast imaging and an atlas on breast ultrasound and biopsy techniques that facilitate accurate diagnosis and treatment Timely, special chapter on the influence of the media and the internet on breast cancer care and the funding of breast cancer research A detailed overview of currently open and accruing clinical trials, along with the future critical questions that must be answered to move the field forward Coverage of molecular findings that provides an enhanced perspsective on the full spectrum of malignancies with which they work

Gregor Und Der Schl Ssel Zur Macht

Author: Suzanne Collins
Publisher: Verlag Friedrich Oetinger GmbH
ISBN: 3862741443
Size: 44.64 MB
Format: PDF, Docs
View: 3823
Download and Read
Band zwei der spannenden Kinderbuchreihe der Bestsellerautorin Suzanne Collins ("Die Tribute von Panem") nun erstmals auch digital erleben! Für ein etwas jüngeres Publikum, aber ebenso fesselnd und mitreißend! Über unterirdische Wasser in ein geheimnisvolles Labyrinth ... Gregor fasst es nicht. Eben noch hat er mit seiner kleinen Schwester Boots im Central Park gespielt und auf einmal ist sie verschwunden. Ein riesiges Kakerlakenbein weist ihm den Weg ins Unterland - jenes Land unterhalb von New York, in das Gregor nie wieder zurückwollte. Dort warten schon seine Fledermaus Ares, die rebellische Prinzessin Luxa und eine neue Prophezeiung auf ihn. Es geht um eine weiße Ratte und darum, dass Gregor verlieren könnte, was er am meisten liebt. Gregor hat keine Wahl: Er muss sich der Prophezeiung stellen und den gefährlichen Weg übers Wasser in das Herz des Labyrinths wagen. Denn an diesem Ort wird er über die Zukunft des Landes entscheiden ... Das zweite Abenteuer von Gregor im Unterland - hoch spannend, fantastisch und atemberaubend.

Issues In Hematology 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 146496596X
Size: 80.29 MB
Format: PDF, Docs
View: 428
Download and Read
Issues in Hematology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hematology. The editors have built Issues in Hematology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hematology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Hematology / 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cancer New Insights For The Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464900027
Size: 57.96 MB
Format: PDF, ePub
View: 7686
Download and Read
Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.