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Natural Products Chemistry

Author: Raymond Cooper
Publisher: CRC Press
ISBN: 1466567627
Size: 15.99 MB
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Notoriously cumbersome to isolate and challenging to synthesize, the path of natural products to viable drugs is an arduous journey. Yet compounds isolated from nature may possess fascinating structures, biological profiles and pharmaceutical potential far greater than anything made by man. Natural Products Chemistry: Sources, Separations and Structures presents a practical guide to sourcing, isolating, and discovering new compounds from nature many of which become pharmaceutical drugs. This book emphasizes the challenges and advantages of products acquired from nature, compared to those obtained from combinatorial chemistry. A basic introduction, the book describes the whole cycle from farm to final compound, backed up by case studies drawn from industry and research applications. It broadens the scope of applications and draws upon examples from various sources. Natural products chemistry, as taught today, draws its examples mainly from marine chemistry or plant chemistry; however, there is also a fascinating and rich world of fermented (microbial and algal) products leading to complex structures. Thus, the book draws upon examples from the microbial world and from insects too. Therefore, this is a source of bioactive metabolites, not traditionally available in academic settings, more the mainstay of the pharmaceutical industry. Providing a roadmap of the process of collecting a compound from nature, isolating the active ingredient, and determining the chemical structure, this book provides a unique approach to the world of natural products.

Natural Products Desk Reference

Author: John Buckingham
Publisher: CRC Press
ISBN: 1439873623
Size: 56.32 MB
Format: PDF
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Written by the team that brought you the prestigious Dictionary of Natural Products (DNP), the Natural Products Desk Reference provides a concise overview of the key structural types of natural products and their interrelationship. A structurally diverse group, ranging from simple aliphatic carbon chains to high molecular weight proteins, natural products can usually be classified into one or more groups. The text describes these major types, including flavonoids, carbohydrates, terpenoids, polyketides, and lipids, and it illustrates them with accurate chemical structures, demonstrating the biosynthetic relationships between groups. Provides details of specialist natural products journals and journals in biochemistry, biology, medicinal chemistry, organic chemistry, pharmacy, pharmacology, and toxicology that may contain important information on natural products Includes types of names that can be used for natural products, comprising functional parent names, trivial names, systematic names, semisystematic names, and semitrivial names Covers stereochemistry topics specific to natural products Presents an overview of the natural world and its classification, focusing on organisms that are the richest sources of natural products Details known types of natural product skeletons with their numbering, or where there are skeletal variations within the group, an illustration is given of a representative example compound Discusses carbohydrate nomenclature impacts on stereochemistry, and on the nomenclature of compounds other than mainstream carbohydrates Reviews general precautions for handling chemicals in a laboratory environment, highlighting hazards resulting from the acute toxicological and pharmacological properties of some classes of natural products and hazards associated with the use of organic solvents In addition to being a companion resource to the DNP, the Natural Products Desk Reference provides you with a mass of other useful information which can sometimes be hard to track down. In compiling it, the authors have drawn on over 20 years of day-to-day experience in the description and classification of all types of natural product.

Botanical Miracles

Author: Raymond Cooper
Publisher: CRC Press
ISBN: 1498788181
Size: 53.23 MB
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As the shortcomings of purely synthetic approaches to biochemical discovery and development are becoming more apparent, a renaissance of interest in the chemistry of natural products as sources for new compounds is occurring. A unique approach to natural products chemistry, Botanical Miracles: Chemistry of Plants That Changed the World relates applications of plant extracts to the historical progress of civilization. It focuses on selected plants from around the world, connecting their stories and properties to the development of modern marvels such as medicinal compounds, nutrition products, beverages, perfumes and organic pigments. Each chapter describes a particular group of plant extracts from various perspectives, including their chemistry, interest and value to man and historical background. The ends of the chapters pose challenging questions. Introducing plants that are emerging into more prominent roles in human life and addressing current challenges, Botanical Miracles presents a fascinating point of entry to the chemistry of important natural products. It examines plants and their extracts through the key functional groups, building blocks and concepts of organic chemistry. This book provides, in a single source, information and learning opportunities of value to a wide range of individuals involved in the fields of chemistry, medicine, nutrition or cosmetics whether they be students, educators, researchers or those who simply wish to extend their horizons.

Chemistry Of Natural Products

Author: Sujata V. Bhat
Publisher: Springer Science & Business Media
ISBN: 9783540406693
Size: 14.42 MB
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View: 2009
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During the last few decades, research into natural products has advanced tremendously thanks to contributions from the fields of chemistry, life sciences, food science and material sciences. Comparisons of natural products from microorganisms, lower eukaryotes, animals, higher plants and marine organisms are now well documented. This book provides an easy-to-read overview of natural products. It includes twelve chapters covering most of the aspects of natural products chemistry. Each chapter covers general introduction, nomenclature, occurrence, isolation, detection, structure elucidation both by degradation and spectroscopic techniques, biosynthesis, synthesis, biological activity and commercial applications, if any, of the compounds mentioned in each topic. Therefore it will be useful for students, other researchers and industry. The introduction to each chapter is brief and attempts only to supply general knowledge in the particular field. Furthermore, at the end of each chapter there is a list of recommended books for additional study and a list of relevant questions for practice.

Introduction To Natural Products Chemistry

Author: Rensheng Xu
Publisher: CRC Press
ISBN: 1439860769
Size: 48.47 MB
Format: PDF
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Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry. Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis. Specifically, this book covers: Extraction and isolation of natural products Chemistry of fungal products Alkaloids, sesquiterpenoids, diterpenes, and saponins Amino acids and peptides Flavonoids, anthraquinones, coumarins, and lignans Marine natural products Structural modification of active principles from traditional Chinese medicine Chemical synthesis of natural products Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

Bioactive Natural Products

Author: Steven M. Colegate
Publisher: CRC Press
ISBN: 9781420006889
Size: 68.95 MB
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Bioactive natural products are proving to be a rich source of novel therapeutics to both protect against and combat diseases, as well as serve as lead compounds in crop protection. Following the successful format of the first edition, this volume brings together collective research from many new contributors and emphasizes the rationale behind the successful detection, isolation, and structure determination of specific compounds. The text encompasses a diverse range of techniques that can be applied to terrestrial and aquatic sources. It also allows you to understand how source material can be selected to enhance your opportunity to discover and utilize novel bioactive natural products. New to the Second Edition— · Advances in the application of NMR spectroscopy and mass spectrometry, bioactive chemical detection and extraction, dereplication, and novel bioassay development · New case studies and illustrations that demonstrate the practical applications of specific techniques · A group of new contributors presenting research from their own laboratories that emphasize both the philosophy and rationale behind detection, isolation, and structural determination Following an overview of natural product chemistry techniques and approaches, many new chapters discuss selection of source material, quantitative NMR, high speed counter-current chromatography, dereplication of extracts, and methods to determine the stereochemistry of bioactive natural products. Examinations of new technologies including LC-NMR, biosensors, and biofingerprinting accompany discussions on the search for specific activities in anticancer and antimalarial applications, seed germination stimulation, and mammalian toxicity. With the participation from active researchers, this definitive work supplies a vital extension and an enduring contribution to the science and art of bioactive natural product detection, isolation, and structural determination.

Natural Product Chemistry At A Glance

Author: Stephen P. Stanforth
Publisher: Wiley-Blackwell
ISBN: 9781405145626
Size: 79.93 MB
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Natural products have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new synthetic reactions and methodologies. Many of the most important synthetic reactions in chemistry have been developed in the quest to characterise and synthesise these materials. Natural Product Chemistry at a Glance provides a concise overview of the main principles and reactions of natural product chemistry, for students studying chemistry and related courses at undergraduate level. Based on the highly successful and student friendly "at a glance" approach, the material developed in this book has been chosen to reinforce the principles of elementary organic reactions and to highlight the similarity between many organic reactions and biological processes. It will also serve as an initial platform for more advanced excursions into the origin of natural products. Students using Natural Product Chemistry at a Glance will find they have a resource with which they can quickly, economically and confidently acquire, regularly review and revise the basic facts that underpin the biosynthesis and chemistry of natural products.

Isolation Identification And Characterization Of Allelochemicals Natural Products

Author: Diego A Sampietro
Publisher: CRC Press
ISBN: 9781578085774
Size: 27.16 MB
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A lot of allelopathy research has been done in various fields of Agricultural and Plant Sciences. However, there is no compilation of various research methods used. To make available the standard methods for conducting allelopathy research independently, this multi-volume book has been planned. Since allelopathy is multi-disciplinary area of research, hence, volumes have been planned for each discipline. This book has been written to provide information about all aspects of Allelochemicals/Natural Products. The book is divided in 3 sections Sample Collection, Handling and Storage; Isolation, Identification and Structural Elucidation and Biological Activity of Natural Products. This book will serve as ready reference in the laboratory or class room to undergraduate and graudate students and Organic Chemists for Isolation, Identification and Characterization of Allelochemicals/Natural Products. The editors have tried to provide appropriate solutions to the problems of Isolation, Identification and Characterization of Allelochemicals/Natural Products. The users of this book can select suitable methods, according to the available facilities.

Gc Ms

Author: Marvin C. McMaster
Publisher: John Wiley & Sons
ISBN: 1118210050
Size: 43.19 MB
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Updated and expanded, the classic guide to GC/MS helps chromatographers quickly learn to use this technique for analyzing and identifying compounds. After explaining the fundamentals, it discusses optimizing, tuning, using, and maintaining GC/MS equipment; explores advances in miniaturized and field-portable GC/MS systems and microfluidic components; and more. Complete with a CD-ROM, it covers applications in the environmental laboratory and in forensics, toxicology, and space science. This is the premier resource for professionals in those fields and for students.

Modern Alkaloids

Author: Ernesto Fattorusso
Publisher: John Wiley & Sons
ISBN: 3527621083
Size: 45.93 MB
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This book presents all important aspects of modern alkaloid chemistry, making it the only work of its kind to offer up-to-date and comprehensive coverage. While the first part concentrates on the structure and biology of bioactive alkaloids, the second one analyzes new trends in alkaloid isolation and structure elucidation, as well as in alkaloid synthesis and biosynthesis. A must for biochemists, organic, natural products, and medicinal chemists, as well as pharmacologists, pharmaceutists, and those working in the pharmaceutical industry.