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Nature S Robots

Author: Charles Tanford
Publisher: OUP Oxford
ISBN: 0191578517
Size: 20.39 MB
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Proteins are amazingly versatile molecules. They make the chemical reactions happen that form the basis for life, they transmit signals in the body, they identify and kill foreign invaders, they form the engines that make us move, and they record visual images. All of this is now common knowledge, but it was not so a hundred years ago. Nature's Robots is an authoritative history of protein science, from the origins of protein research in the nineteenth century, when the chemical constitution of 'protein' was first studied and heatedly debated and when there was as yet no glimmer of the functional potential of substances in the 'protein' category, to the determination of the first structures of individual proteins at atomic resolution - when positions of individual atoms were first specified exactly and bonding between neighbouring atoms precisely defined. Tanford and Reynolds, who themselves made major contributions to the golden age of protein science, have written a remarkably vivid account of this history. It is a fascinating story, involving heroes from the past, working mostly alone or in small groups, usually with little support from formal research groups. It is also a story that embraces a number of historically important scientific controversies. Written in clear and accessible prose, Nature's Robots will appeal to general readers with an interest in popular science, in addition to professional scientists and historians of science.

Zufall Im Leben Der Zelle

Author: Hartmut Kuthan
Publisher: Engelsdorfer Verlag
ISBN: 3960082053
Size: 61.32 MB
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Dieses Buch handelt von den fundamentalen zellbiologischen Prinzipien und vielfältigen Rollen zufälliger Ereignisse im Vererbungsgeschehen, in der Entwicklung und Evolution der Organismen. In der Organismenwelt, schon in der einzelnen Zelle, tritt uns die einzigartige Organisation des Lebens entgegen. Bis in die Gegenwart dominieren deterministische Mechanismen und Modelle die Beschreibung der geordneten Abläufe der Lebenserscheinungen. Doch die vielfältigen Zellfunktionen haben ihren Ursprung in stochastischen molekularen Prozessen. Welche Brücken führen von den mit Unsicherheit behafteten Interaktionen einzelner (Makro-)Moleküle zu den gesetzmäßig ablaufenden Zellprozessen? Und welche besonderen Eigenschaften dieser Moleküle ermöglichen diesen Brückenschlag? Auf diese Fragen hatte bereits Erwin Schrödinger in seinem bekannten Buch Was ist Leben? Antworten gesucht. Dank der großartigen molekularbiologischen und biophysikalischen Erkenntnisse in den seither verflossenen siebzig Jahren können diese Fragen heute beantwortet werden - mit überraschenden Einsichten. Über den Autor: Hartmut Kuthan ist promovierter Naturwissenschaftler. Sein wissenschaftliches Interesse gilt der Beschreibung zellulärer Prozesse durch stochastische Modelle und interdisziplinären Fragestellungen. Er ist Verfasser des Buches »Das Zufallsprinzip: Vom Ereignis zum Gesetz«.

The Quest For The Cure

Author: Brent R. Stockwell
Publisher: Columbia University Press
ISBN: 9780231525527
Size: 71.29 MB
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After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century. Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research. Scientists such as Stockwell are now developing methods to combat these complexities technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

The Edge Of Evolution

Author: Michael J. Behe
Publisher: Simon and Schuster
ISBN: 0743296222
Size: 28.86 MB
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The author of Darwin's Black Box draws on new findings in genetics to pose an argument for intelligent design that refutes Darwinian beliefs about evolution while offering alternative analyses of such factors as disease, random mutations, and the human struggle for survival. Reprint. 40,000 first printing.

Contested Categories

Author: Ayo Wahlberg
Publisher: Ashgate Publishing, Ltd.
ISBN: 1409492036
Size: 67.17 MB
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Drawing on social science perspectives, Contested Categories presents a series of empirical studies that engage with the often shifting and day-to-day realities of life sciences categories. In doing so, it shows how such categories remain contested and dynamic, and that the boundaries they create are subject to negotiation as well as re-configuration and re-stabilization processes. Organized around the themes of biological substances and objects, personhood and the genomic body and the creation and dispersion of knowledge, each of the volume’s chapters reveals the elusive nature of fixity with regard to life science categories. With contributions from an international team of scholars, this book will be essential reading for anyone interested in the social, legal, policy and ethical implications of science and technology and the life sciences.

Toward A New Dimension

Author: Anne Marcovich
Publisher: OUP Oxford
ISBN: 0191024015
Size: 79.22 MB
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Over the course of the last thirty years, the investigation of objects at the nano scale has rocketed. Nanoscale scientific research has not only powerfully affected the amount and orientation of knowledge, it has perhaps even more significantly redirected the ways in which much research work is carried out, changed scientists' methodology and reasoning processes, and influenced aspects of the structure of career trajectory and the functioning of scientific disciplines. This book identifies key historical moments and episodes in the birth and evolution of nanoscience, discusses the novel repertory of epistemological concerns of practitioners, and signals sociological propensities. As Galileo's telescope explored the moon's surface four hundred years ago, nano instrumentation now makes it possible to see the surface of single molecules. Moreover, practitioners are able to manipulate individual atoms and molecules at will to produce pre-designed synthetic materials, non-existent in nature. The combinatorial of heightened observational capacity and the tailoring of synthetic artificial materials exhibiting hitherto novel physical properties has widened and transformed the worlds of scientific knowledge and technical artefact. This book invites the question: to what extent does nanoscale scientific research constitute a kind of 'scientific revolution'?

I Died For Beauty

Author: Marjorie Senechal
Publisher: Oxford University Press
ISBN: 0199910839
Size: 74.40 MB
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In the vein of A Beautiful Mind, The Man Who Loved Only Numbers, and Rosalind Franklin: The Dark Lady of DNA, this volume tells the poignant story of the brilliant, colorful, controversial mathematician named Dorothy Wrinch. Drawing on her own personal and professional relationship with Wrinch and archives in the United States, Canada, and England, Marjorie Senechal explores the life and work of this provocative, scintillating mind. Senechal portrays a woman who was learned, restless, imperious, exacting, critical, witty, and kind. A young disciple of Bertrand Russell while at Cambridge, the first women to receive a doctor of science degree from Oxford University, Wrinch's contributions to mathematical physics, philosophy, probability theory, genetics, protein structure, and crystallography were anything but inconsequential. But Wrinch, a complicated and ultimately tragic figure, is remembered today for her much publicized feud with Linus Pauling over the molecular architecture of proteins. Pauling ultimately won that bitter battle. Yet, Senechal reminds us, some of the giants of mid-century science--including Niels Bohr, Irving Langmuir, D'Arcy Thompson, Harold Urey, and David Harker--took Wrinch's side in the feud. What accounts for her vast if now-forgotten influence? What did these renowned thinkers, in such different fields, hope her model might explain? Senechal presents a sympathetic portrait of the life and work of a luminous but tragically flawed character. At the same time, she illuminates the subtler prejudices Wrinch faced as a feisty woman, profound culture clashes between scientific disciplines, ever-changing notions of symmetry and pattern in science, and the puzzling roles of beauty and truth.

Fundamentals Of Biochemistry

Author: Donald Voet
Publisher: John Wiley & Sons Incorporated
ISBN: 9780471214953
Size: 46.89 MB
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This text uses a more brief and qualitative approach to present biochemistry with chemical rigor, focusing on the structures of biomolecules, chemical mechanisms, and evolutionary relationships. It is written to impart a sense of intellectual history of biochemistry, an understanding of the tools and approaches used to solve biochemical puzzles, and a hint of the excitement that accompanies new discoveries. This edition has been thoroughly updated to reflect the most recent advances in biochemistry, particularly in the areas of genomics and structural biology. A new chapter focuses on cytoskeletal and motor proteins, currently one of the most active areas of research in biochemistry.

Genetics

Author: Daniel L. Hartl
Publisher: Jones & Bartlett Learning
ISBN:
Size: 79.13 MB
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This handbook covers all dimensions of breast cancer prevention, diagnosis, and treatment for the non-oncologist. A special emphasis is placed on the long term survivor.