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Neural Tube Defects

Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 0470514566
Size: 16.72 MB
Format: PDF
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Neural tube defects are the second most common cause of perinatal death from birth defects in the United Kingdom. In this important book, leading scientists evaluate the latest evidence on the causative factors--both genetic and environmental--of these major human congenital malformations. They also discuss prospects for early detection by prenatal screening and for treatment both before and after birth. The extensive coverage encompasses such topics as: formation and patterning of the avian neuraxis, neurulation in mammals and the normal human embryo, folic acid and more.

Neural Tube Defects

Author: Gregory Bock
Publisher: John Wiley & Sons
ISBN: 9780471941729
Size: 41.19 MB
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Neural Tube Defects Chairwoman: Professor Judith Hall 1994 Neural tube defects are major human congenital malformations. They are the second most common cause of perinatal death owing to birth defect in the UK and lead to considerable childhood morbidity. This book contains descriptions of normal neurulation in birds, amphibians and mammals, including humans. The anatomy of neural tube defects is discussed, with emphasis on the underlying molecular genetics, particularly in mouse strains with heritable neural tube defects. There is evidence for both genetic and environmental factors in the development of neural tube defects. Possible risk factors include anticonvulsant agents, diabetes and alcohol: the current status of epidemiological studies on these is assessed and the relative contributions of potential causative elements are critically reviewed. Clinical trials in humans have shown that folic acid consumption before and immediately after conception significantly reduces the risk of having a child with a neural tube defect. The book contains a detailed description of folic acid metabolism and discussion of how it may act during neural tube closure. The book describes methods for antenatal detection and diagnosis of neural tube defects. The feasibility of treatment, both in utero and after birth, is considered. Finally, the book presents the case for implementing a programme to ensure adequate consumption of folic acid by all women of child-bearing age. Possible objections to, or disadvantages of, such a programme are discussed fully and solutions to such problems are proposed. Related Ciba Foundation Symposia: No. 156 The childhood environment and adult disease Chairman: David Barker 1991 ISBN 0 471 92957 3 No. 165 Postimplantation development in the mouse Chairwoman: Anne McLaren 1992 ISBN 0 471 93384 8 No. 182 Germline development Chairwoman: Anne McLaren 1994 ISBN 0 471 94264

Dietary Supplements And Health

Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 9780470319451
Size: 63.35 MB
Format: PDF, Kindle
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Dietary supplements can contain a wide variety of ingredients, either singly or in combination, including nutrients, botanicals and 'bioactive components' commonly found in foods. They are marketed and used by consumers for a range of reasons: to enhance "well-being", as traditional medicines, for health promotion or disease risk reduction, and as alternatives or complements to conventional drug therapies. On a global basis, the dietary supplement industry has enjoyed rapid growth, becoming a multi-billion dollar enterprise over the last 10 years. This growth has been associated with significant changes in both the types of products available and the reasons for using these products. In many cases, these changes have occurred without the benefit of a sound scientific basis for evaluating the safety and efficacy of these products under the new conditions of use and frequently the same limited scientific evidence is used, even though current product composition, user populations, purported beneficial effects, and conditions of use may differ significantly from the available evidence or historical usage. This book presents systematic examinations of the scientific data that are available and/or needed to substantiate and evaluate the safety and efficacy of dietary supplements. A series of case studies that are illustrative of the types of scientific challenges that have been encountered in substantiating safety and efficacy for various product types are employed to point out some of the successes but also frustrations that have occurred in recent years. Discussions among presenters and participants identify the lessons learned from these experiences and formulate ideas for improved approaches to identifying research needs and for enhancing the quality and relevance of the scientific evidence available for policy decisions. Dietary Supplements and Health constitutes a useful resource for nutritionists, biochemists, public health researchers and anyone interested in herbal, alternative medicines.

Abortion

Author: Ruth Porter
Publisher: John Wiley & Sons
ISBN: 0470718668
Size: 37.52 MB
Format: PDF, ePub
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Cortical Development

Author: Gregory R. Bock
Publisher: John Wiley & Sons
ISBN: 0470994029
Size: 32.18 MB
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To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.

Nutrition

Author: Frances Sienkiewicz Sizer
Publisher:
ISBN: 9780534446284
Size: 19.60 MB
Format: PDF, ePub
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Fetal And Neonatal Physiology E Book

Author: Richard A. Polin
Publisher: Elsevier Health Sciences
ISBN: 143773636X
Size: 53.54 MB
Format: PDF, Docs
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Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.