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Neuropeptides In Neuroprotection And Neuroregeneration

Author: Fred Nyberg
Publisher: CRC Press
ISBN: 1439830630
Size: 73.35 MB
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Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration. The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers: General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology Neuropeptides known for their impact in neurodegenerative and neuroprotective processes Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Peptide Transport And Delivery Into The Central Nervous System

Author: Laszlo Prokai
Publisher: Birkhäuser
ISBN: 3034880499
Size: 50.29 MB
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Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.

Hormones In Neurodegeneration Neuroprotection And Neurogenesis

Author: Achille G. Gravanis
Publisher: John Wiley & Sons
ISBN: 3527633979
Size: 43.49 MB
Format: PDF
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As life expectancy increases and population ages, the already enormous impact of neurodegeneration on society will become even larger without better prevention and treatment. Developing strategies to prevent degeneration of neurons and to promote a healthy nervous system is, thus, critical. The development of pharmacological agents that would increase production of new neurons was recently facilitated by the identification of the hormonal regulators of various steps of adult neurogenesis. The proposed book is writen by a group of top world experts involved in the study of the mechanisms of hormonal control of brain damage and repair. The effects of thyroid and steroid hormones (estrogens, androgens, progestins, gluco-mineralo-corticoids, various neurosteroids) or polypeptide hormones (CRF, urocortins, somatostastin, GH/IGF, leptin, prolactin, PACAP, erythropoetin) on neuronal survival and neurogenesis in various neurodegenerative conditions and in brain aging will be discussed in detail. The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

Advances In Research On Neurodegeneration

Author: P. Riederer
Publisher: Springer Science & Business Media
ISBN: 3709168422
Size: 30.78 MB
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Volume 5 of the series "Advances in Research on Neurodegeneration" is concerned with themes which are currently the focus of intensive research, and in which advances in our understanding of the pathological mechanisms un derlying neurodegenerative diseases are expected in the near future. The first section contains five reviews devoted to the various neuroimaging technolo gies. The discussion is concerned with the question of whether neuroimaging techniques make it possible to follow the process of degeneration as it occurs, and which methods offer the required sensitivity and quantifiability for this purpose. However, the question needs to be examined of whether, given the physical and chemical limitations of these techniques, even under optimal conditions, anatomical resolution can be improved to the extent that neuro degenerative diseases can be diagnosed earlier than currently possible and a confident diagnosis made. The possibilities of using neuroimaging techniques to provide information regarding the effects of neuroprotective or neuroregen erative therapeutic strategies, and for correlating the results of neuropsycho logical research with imaging data are also discussed. The second section is concerned with the significance of endogenous or exogenous neurotoxins as triggers for neurodegenerative processes that may lead to Parkinsonism. Vulnerability factors, which include such factors as nerve ending sensitivity, the synergistic effects of drugs and the various mechanisms underlying different toxins are discussed.

Neurodegeneration And Neuroprotection In Parkinson S Disease

Publisher: Elsevier
ISBN: 9780080537412
Size: 54.42 MB
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Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most divers and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological, and therapeutic aspects of chosen research areas.

Advances In Research On Neurodegeneration

Author: Peter Riederer
Publisher: Springer Science & Business Media
ISBN: 9783211829332
Size: 12.69 MB
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The "International Winter Conferences on Neurodegeneration" have become an established forum to discuss various aspects of basic and clinical topics related to the underlying mechanisms of neurodegenerative disorders. This volume focuses on brain imaging, endogenous and exogenous neurotoxins, programmed cell death, apoptosis and necrosis, and immunoinflammatory mechanisms, infective diseases causing neurological disorders. These topics have been reviewed by invited experts and the articles give an up-to-date reflection of the state of the art in these research fields.

Parkinson S Disease

Author: Dr. Stewart A. Factor, DO
Publisher: Demos Medical Publishing
ISBN: 9781934559871
Size: 17.12 MB
Format: PDF, Kindle
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Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.


Author: Curt A. Sandman
Size: 18.98 MB
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This volume discusses the conservation of function across a range of species, illustrated in studies of insects, nematodes, tadpoles, mice, and rats, and in humans. The rate of embryonic and fietal development appears to be under the control of neuropeptides implicated in the stress response.