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Neurotoxin Modeling Of Brain Disorders Life Long Outcomes In Behavioral Teratology

Author: Richard M. Kostrzewa
Publisher: Springer
ISBN: 3319341367
Size: 19.88 MB
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This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

Handbook Of Developmental Neurotoxicology

Author: William Slikker, Jr.
Publisher: Academic Press
ISBN: 0128093943
Size: 50.66 MB
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Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Addictive Substances And Neurological Disease

Author: Ronald Ross Watson
Publisher: Academic Press
ISBN: 0128092963
Size: 11.33 MB
Format: PDF, ePub
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Addictive Substances and Neurological Disease: Alcohol, Tobacco, Caffeine, and Drugs of Abuse in Everyday Lifestyles is a complete guide to the manifold effects of addictive substances on the brain, providing readers with the latest developing research on how these substances are implicated in neurological development and dysfunction. Cannabis, cocaine, and other illicit drugs can have substantial negative effects on the structure and functioning of the brain. However, other common habituating and addictive substances often used as part of an individual’s lifestyle, i.e., alcohol, tobacco, caffeine, painkillers can also compromise brain health and effect or accentuate neurological disease. This book provides broad coverage of the effects of addictive substances on the brain, beginning with an overview of how the substances lead to dysfunction before examining each substance in depth. It discusses the pathology of addiction, the structural damage resulting from abuse of various substances, and covers the neurobiological, neurodegenerative, behavioral, and cognitive implications of use across the lifespan, from prenatal exposure, to adolescence and old age. This book aids researchers seeking an understanding of the neurological changes that these substances induce, and is also extremely useful for those seeking potential treatments and therapies for individuals suffering from chronic abuse of these substances. Integrates current research on the actions of addictive substances in neurological disease Includes functional foods, such as caffeine beverages, that have habituating effects on the brain Provides a synopsis of key ideas associated with the consequences of addictive and habituating lifestyle substances

Handbook Of Neurotoxicity

Author: Richard Kostrzewa
Publisher: Springer
ISBN: 9781461458357
Size: 25.40 MB
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The Handbook of Neurotoxicity is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Modeling The Psychopathological Dimensions Of Schizophrenia

Author: Mikhail Pletnikov
Publisher: Academic Press
ISBN: 012801184X
Size: 56.14 MB
Format: PDF, Docs
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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Instrument Engineers Handbook Fourth Edition Volume Two

Author: Bela G. Liptak
Publisher: CRC Press
ISBN: 9781420064001
Size: 45.93 MB
Format: PDF, Kindle
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The latest update to Bela Liptak's acclaimed "bible" of instrument engineering is now available. Retaining the format that made the previous editions bestsellers in their own right, the fourth edition of Process Control and Optimization continues the tradition of providing quick and easy access to highly practical information. The authors are practicing engineers, not theoretical people from academia, and their from-the-trenches advice has been repeatedly tested in real-life applications. Expanded coverage includes descriptions of overseas manufacturer's products and concepts, model-based optimization in control theory, new major inventions and innovations in control valves, and a full chapter devoted to safety. With more than 2000 graphs, figures, and tables, this all-inclusive encyclopedic volume replaces an entire library with one authoritative reference. The fourth edition brings the content of the previous editions completely up to date, incorporates the developments of the last decade, and broadens the horizons of the work from an American to a global perspective. Béla G. Lipták speaks on Post-Oil Energy Technology on the AT&T Tech Channel.

Environmental Neurotoxicology

Author: Board on Environmental Studies and Toxicology
Publisher: National Academies Press
ISBN: 0309045312
Size: 27.32 MB
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Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity--the concept that long-term impairments can escape clinical detection--makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Neurological Disorders

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241563362
Size: 37.47 MB
Format: PDF, Mobi
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Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Mental Codes

Author: Michael J. Duckett
Publisher:
ISBN: 9781974463633
Size: 23.71 MB
Format: PDF, Kindle
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The Secret Mental Codes of the mind possess the power to miraculously transform any life into a source of unbelievable power and success.Dr. Michael J. and Leslie P. Duckett have decoded the Mental Code Formula and made it available to the general public for the first time.Because of the power of the Mental Code Discovery, there is no telling what it will do for the entire population on this planet. Human Beings have just been given the most powerful ability in the universe to create whatever life they so desire-The Mental Codes.And now...it can happen for you!

Noradrenergic Neurons

Author: Marianne Fillenz
Publisher: Cambridge University Press
ISBN: 9780521287807
Size: 63.32 MB
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A unique up-to-date synthesis of current knowledge on the biochemical, anatomical and physiological aspects of this important group of brain and peripheral nervous system cells.