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Nuclear Receptors

Author: Chris M. Bunce
Publisher: Springer Science & Business Media
ISBN: 9789048133031
Size: 51.64 MB
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In 1890 a case of myxedema was treated in Lisbon by the implantation of a sheep thyroid gland with the immediate improvement in the patient’s condition. A few years later, medications for the then ill-explained condition of the menopause included tablets made from cow ovaries. In the first quarter of the 20th century the identification of vitamin D, and its sunlight driven production in skin, paved the way to the elimination of rickets as a major medical problem. Twenty years or so later, Sir Vincent Wigglesworth established the endocrine basis of developmental moulting in insects, arguably the most commonly performed animal behaviour on Planet Earth. A paradigm that would unify these disparate observations arose between 1985 and 1987 beginning with the identification of the glucocorticoid receptor and the nuclear receptor super-family. What follows is a timely and positive manifestation of the capacity, productivity and value of international human scientific endeavour. Based on intrigue, lively competition and cooperation a global effort has rapidly fostered a school of biology with widespread ramifications for the understanding of metazoan animals, the human condition and the state of the planet. This book is the first this century to try and capture the spirit of this endeavour, to depict where the field is now and to identify some of the challenges and opportunities for the future.

Insect Endocrinology

Author: Lawrence I. Gilbert
Publisher: Academic Press
ISBN: 0123848512
Size: 66.46 MB
Format: PDF, ePub
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The publication of the extensive seven-volume work Comprehensive Molecular Insect Science provided a complete reference encompassing important developments and achievements in modern insect science. One of the most swiftly moving areas in entomological and comparative research is endocrinology, and this volume, Insect Endocrinology, is designed for those who desire a comprehensive yet concise work on important aspects of this topic. Because this area has moved quickly since the original publication, articles in this new volume are revised, highlighting developments in the related area since its original publication. Insect Endocrinology covers the mechanism of action of insect hormones during growth and metamorphosis as well as the role of insect hormones in reproduction, diapause and the regulation of metabolism. Contents include articles on the juvenile hormones, circadian organization of the endocrine system, ecdysteroid chemistry and biochemistry, as well as new chapters on insulin-like peptides and the peptide hormone Bursicon. This volume will be of great value to senior investigators, graduate students, post-doctoral fellows and advanced undergraduate research students. It can also be used as a reference for graduate courses and seminars on the topic. Chapters will also be valuable to the applied biologist or entomologist, providing the requisite understanding necessary for probing the more applied research areas. Articles selected by the known and respected editor-in-chief of the original major reference work, Comprehensive Molecular Insect Science Newly revised contributions bring together the latest research in the quickly moving field of insect endocrinology Review of the literature of the past five years is now included, as well as full use of data arising from the application of molecular technologies wherever appropriate

Osteosynthesis In The Hand

Author: Daniel B. Herren
Publisher: Karger Medical and Scientific Publishers
ISBN: 380558542X
Size: 26.51 MB
Format: PDF, Kindle
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Fracture fixation in osteoporotic bone, fixed angle implants, bone morphogenic proteins - these are just a few of the phrases recently heard in discussions on contemporary osteosynthesis. Featuring the proceedings of the 2008 congress of the Federation of European Societies for Surgery of the Hand (FESSH) held in Lausanne, this book provides a comprehensive overview of the state of the art and summarizes the various new developments in osteosynthesis. Basic scientific papers and contributions reporting important clinical applications by leaders in their fields highlight some recent issues such as fracture fixation under special conditions, new implant designs, bone substitutes and outcome measurement after fracture treatment. Hand surgeons, orthopedic and trauma surgeons as well as researchers with an interest in fracture treatment of the upper extremity will find this publication of great interest.

Cardio Renal Clinical Challenges

Author: David Goldsmith
Publisher: Springer
ISBN: 331909162X
Size: 60.21 MB
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​​​​​​​​In modern medicine, the aging population is prone to many simultaneous cardiovascular (CV) risk factors which often produce co-incident pathology. Nowhere is this more obvious than in the interaction between Chronic Kidney Disease (CKD), Diabetes and diverse CV diseases (CVD). This is a complex and challenging area, as the presence of CKD/diabetes promotes CVD while also complicating its treatment. The emergence of CKD as a public health priority is one of the most challenging problems of modern medicine. It is now solidly established that renal dysfunction portends a high risk for cardiovascular disease. Cardiovascular diseases remains the main cause of death in western societies and the amplification of the death risk conveyed by coexisting CKD, even though still poorly understood, appears considerable. The bidirectional link that associates renal and cardiovascular diseases, the high risk of the death signalled by their coexistence and the considerable epidemiological burden imposed by this link is at the basis of the emergence of a new discipline aiming at making the borders between nephrology and cardiovascular medicine even more permeable than before. The term Cardio-Renal Syndrome was coined around 5 years ago to try to formalize this link, and act as a stimulus to interaction between clinical teams, researchers and others to achieve better management and outcomes for all. This book takes clinical presentations and clinical problems as its base, and then discuss the evidence for best management of common clinical problems as well as the reasons for the complex interplay between the cardiac and renal systems. Moreover, it addresses the issue of organizing healthcare to maximize the opportunities for prevention and best healthcare economic returns, building on cutting edge initiatives at the Karolinska, Stockholm. The book will be of immediate value and interest to all cardiologists and renal physicians.

Molecular Endocrinology

Author: Bruce D. Weintraub
Publisher: Lippincott Williams & Wilkins
ISBN:
Size: 28.81 MB
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Discusses DNA sequence analysis/localizing mutations in human genes/cloning expression of polypeptide hormone genes

Cell Biology

Author:
Publisher:
ISBN: 9783882220407
Size: 66.66 MB
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Archive on the cytological processes in 92 short "chapters", ranging from microscopy of anthrax & tetanus bacilli to footage of gastrulation in the newt egg.