Download obesity and breast cancer the role of dysregulated estrogen metabolism springerbriefs in cancer research in pdf or read obesity and breast cancer the role of dysregulated estrogen metabolism springerbriefs in cancer research in pdf online books in PDF, EPUB and Mobi Format. Click Download or Read Online button to get obesity and breast cancer the role of dysregulated estrogen metabolism springerbriefs in cancer research in pdf book now. This site is like a library, Use search box in the widget to get ebook that you want.



Obesity And Breast Cancer

Author: Kristy A. Brown
Publisher: Springer Science & Business Media
ISBN: 1489980024
Size: 44.78 MB
Format: PDF, ePub, Docs
View: 1108
Download and Read
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research.​

Mirnas And Target Genes In Breast Cancer Metastasis

Author: Seema Sethi
Publisher: Springer
ISBN: 9783319081618
Size: 18.14 MB
Format: PDF, ePub
View: 162
Download and Read
This SpringerBrief gives the latest research on the role of miRNAs in breast cancer metastasis. MicroRNAs (miRNAs) are recently described small endogenous noncoding RNAs implicated in the posttranscriptional control of gene expression. These tiny molecules are involved in developmental, physiologic phenomenon as well as pathologic processes including cancers. In fact, miRNAs have emerged as critical regulators of cancer progression, invasion and metastasis. This is mainly because a single miRNA can affect several downstream genes and signaling pathways with oncogenic or tumor suppressor actions depending on the target genes affected. Due to this multimodal downstream signaling effects, these small endogenous molecules hold great promise in metastasis prevention and treatment. Modulating the activity of miRNAs can provide opportunities for novel cancer interventions. Targeting miRNAs could become a novel prognostic and therapeutic strategy to prevent the future development of metastasis. Thus, miRNAs could also serve as a potential targets for anti-metastatic therapy. The book explores how the expression of miRNAs in the primary tumor could be silenced using antagomirs (chemically modified anti-miRNA oligonucleotides), which could prevent the development of metastasis; whereas once metastasis develops then it could be treated with miRNA mimics for inducing its expression for the treatment. Therefore, development of miRNA-based prophylactic therapies could serve as precision and personalized medicine against future development of metastasis of breast and other cancers.

Neglected Tropical Diseases Middle East And North Africa

Author: Mary Ann McDowell
Publisher: Springer
ISBN: 3709116139
Size: 46.44 MB
Format: PDF, Docs
View: 4329
Download and Read
The Middle East and North Africa (MENA) is highly endemic for several neglected tropical diseases (NTDs), including viral, bacterial, protozoan and helminth infections. This new volume covers the most prevalent NTDs found in about 22 MENA countries emphasizing the disease burden, clinical manifestations and control approaches. Each individual chapter deals with one specific disease and is written by a group of experts on that topic.

Anticancer Plants Natural Products And Biotechnological Implements

Author: Mohd Sayeed Akhtar
Publisher: Springer
ISBN: 981108064X
Size: 35.80 MB
Format: PDF, Kindle
View: 220
Download and Read
This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Liquorice

Author: Münir Öztürk
Publisher: Springer
ISBN: 331974240X
Size: 60.71 MB
Format: PDF
View: 3049
Download and Read
Licorice (Glycyrrhiza) is one of the most widely used in foods, herbal medicine and one of the extensively researched medicinal plants of the world. In traditional medicine licorice roots have been used against treating many ailments including lung diseases, arthritis, kidney diseases, eczema, heart diseases, gastric ulcer, low blood pressure, allergies, liver toxicity, and certain microbial infections. Licorice extract contains sugars, starch, bitters, resins, essential oils, tannins, inorganic salts and low levels of nitrogenous constituents such as proteins, individual amino acids, and nucleic acids. A large number of biologically active compounds have been isolated from Glycyrrhiza species, where triterpene, saponins and flavonoids are the main constitutes which show broad biological activities. The present book will discuss the botany, the commercial interests as well as the recent studies on the phytochemistry and pharmacology of licorice. It will also describe the side effects and toxicity of licorice and its bioactive components, an underrepresented subjects of importance. It will be the first book to present global perspectives of licorice in detail. It will serve as a carefully researched introduction for students, healthcare practitioners, botanists and plant biochemists; full of historical background and bridges the gap between botany, ecology, pharmacology, as well as treatment of diseases.

Anti Diabetes And Anti Obesity Medicinal Plants And Phytochemicals

Author: Bashar Saad
Publisher: Springer
ISBN: 3319541021
Size: 79.30 MB
Format: PDF, ePub, Mobi
View: 5909
Download and Read
This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current and future trends in anti-diabetic medicinal plants. This unique and comprehensive text is the only current book on the market focusing exclusively on medicinal plants used to combat obesity and diabetes. An introductory chapter focuses on diabetes and obesity and introduces the major causes and main treatments of this increasing epidemic in modern society. Readers are then introduced to medicinal plants, including details on their therapeutic aspects, plus side effects and safety. Following chapters focus on anti-diabetic and anti-obesity medicinal plants, as well as phytogenic natural products in the treatment of each. The text closes by focusing on present and future trends and challenges in these medicinal plants. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals: Safety, Efficacy, and Action Mechanisms is a much-needed and truly original work, finally presenting in one place all the necessary information on medicinal plants used in conjunction with obesity and diabetes prevention.

A Practical Guide To Biomedical Research

Author: Peter Agger
Publisher: Springer
ISBN: 3319635824
Size: 16.34 MB
Format: PDF, ePub, Mobi
View: 4872
Download and Read
This book advises and supports novice researchers in taking their first steps into the world of scientific research. Through practical tips and tricks presented in a clear, concise and step-wise manner, the book describes the entire research process from idea to publication. It also gives the reader insight into the vast opportunities a research career can provide. The books target demographic is aspiring researchers within the biomedical professions, be it medical students, young doctors, nurses, engineers, physiotherapists etc. The book will help aspirational inexperienced researchers turn their intentions into actions, providing crucial guidance for successful entry into the field of biomedical research.

Data Driven Process Discovery And Analysis

Author: Karl Aberer
Publisher: Springer
ISBN: 364234044X
Size: 29.18 MB
Format: PDF, ePub
View: 6465
Download and Read
This book constitutes the thoroughly refereed proceedings of the First International Symposium on Data-Driven Process Discovery and Analysis held in Campione d'Italia, Italy, in June/July 2011. The 11 revised full papers were carefully selected from 31 submissions. In addition to the thorough review process, the lively discussions at the event itself also helped the authors to improve their papers and to foster interesting extensions. The selected papers cover a wide range of topics spanning from theoretical issues related to process representation to practical experience in process discovery and analysis.

Hamilton Jacobi Equations Approximations Numerical Analysis And Applications

Author: Yves Achdou
Publisher: Springer
ISBN: 3642364330
Size: 36.81 MB
Format: PDF, Docs
View: 7476
Download and Read
These Lecture Notes contain the material relative to the courses given at the CIME summer school held in Cetraro, Italy from August 29 to September 3, 2011. The topic was "Hamilton-Jacobi Equations: Approximations, Numerical Analysis and Applications". The courses dealt mostly with the following subjects: first order and second order Hamilton-Jacobi-Bellman equations, properties of viscosity solutions, asymptotic behaviors, mean field games, approximation and numerical methods, idempotent analysis. The content of the courses ranged from an introduction to viscosity solutions to quite advanced topics, at the cutting edge of research in the field. We believe that they opened perspectives on new and delicate issues. These lecture notes contain four contributions by Yves Achdou (Finite Difference Methods for Mean Field Games), Guy Barles (An Introduction to the Theory of Viscosity Solutions for First-order Hamilton-Jacobi Equations and Applications), Hitoshi Ishii (A Short Introduction to Viscosity Solutions and the Large Time Behavior of Solutions of Hamilton-Jacobi Equations) and Grigory Litvinov (Idempotent/Tropical Analysis, the Hamilton-Jacobi and Bellman Equations).

Plastics In Dentistry And Estrogenicity

Author: Theodore Eliades
Publisher: Springer Science & Business Media
ISBN: 3642296874
Size: 23.86 MB
Format: PDF, Mobi
View: 4550
Download and Read
This book provides a timely and comprehensive review of our current knowledge of BPA release from dental polymers and the potential endocrinological consequences. After a review of the history and evolution of the issue within the broader biomedical context, the estrogenicity of BPA is explained. The basic chemistry of the polymers used in dentistry is then presented in a simplified and clinically relevant manner. Key chapters in the book carefully evaluate the release of BPA from polycarbonate products and composite resins and the estrogenicity of these materials. Currently available evidence on the potential estrogenic action of dental composities, sealants, and adhesives is presented, and means are suggested by which adverse health effects can be minimized. The entire dental community will find this book to be an excellent source of information on the true risks posed by BPA, and an invaluable aid to safe practice.