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Parabolic Equations In Biology

Author: Benoît Perthame
Publisher: Springer
ISBN: 331919500X
Size: 40.31 MB
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This book presents several fundamental questions in mathematical biology such as Turing instability, pattern formation, reaction-diffusion systems, invasion waves and Fokker-Planck equations. These are classical modeling tools for mathematical biology with applications to ecology and population dynamics, the neurosciences, enzymatic reactions, chemotaxis, invasion waves etc. The book presents these aspects from a mathematical perspective, with the aim of identifying those qualitative properties of the models that are relevant for biological applications. To do so, it uncovers the mechanisms at work behind Turing instability, pattern formation and invasion waves. This involves several mathematical tools, such as stability and instability analysis, blow-up in finite time, asymptotic methods and relative entropy properties. Given the content presented, the book is well suited as a textbook for master-level coursework.

Math And Bio 2010

Author: Lynn Arthur Steen
Publisher: MAA
ISBN: 9780883858189
Size: 12.70 MB
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Math & Bio 2010: Linking Undergraduate Disciplines envisages a new educational paradigm in which the disciplines of mathematics and biology, currently quite separate, will be productively linked in the undergraduate science programs of the 21st century. As a science, biology depends increasingly on data, algorithms, and models; in virtually every respect, it is becoming more quantitative, more computational, and more mathematical. While these trends are related, they are not the same; they represent, rather, three different perspectives on what many are calling the "new biology." All three methods---quantitative, computational, mathematical---are spreading across the entire landscape of biological science from molecular to cellular, organismic and ecological. The aim of this volume is to alert members of both communities---biological and mathematical---to the expanding and exciting challenges of interdisciplinary work in these fields.

Mathematical Methods For Cancer Evolution

Author: Takashi Suzuki
Publisher: Springer
ISBN: 9811036713
Size: 43.99 MB
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The purpose of this monograph is to describe recent developments in mathematical modeling and mathematical analysis of certain problems arising from cell biology. Cancer cells and their growth via several stages are of particular interest. To describe these events, multi-scale models are applied, involving continuously distributed environment variables and several components related to particles. Hybrid simulations are also carried out, using discretization of environment variables and the Monte Carlo method for the principal particle variables. Rigorous mathematical foundations are the bases of these tools.The monograph is composed of four chapters. The first three chapters are concerned with modeling, while the last one is devoted to mathematical analysis. The first chapter deals with molecular dynamics occurring at the early stage of cancer invasion. A pathway network model based on a biological scenario is constructed, and then its mathematical structures are determined. In the second chapter mathematical modeling is introduced, overviewing several biological insights, using partial differential equations. Transport and gradient are the main factors, and several models are introduced including the Keller‒Segel systems. The third chapter treats the method of averaging to model the movement of particles, based on mean field theories, employing deterministic and stochastic approaches. Then appropriate parameters for stochastic simulations are examined. The segment model is finally proposed as an application. In the fourth chapter, thermodynamic features of these models and how these structures are applied in mathematical analysis are examined, that is, negative chemotaxis, parabolic systems with non-local term accounting for chemical reactions, mass-conservative reaction-diffusion systems, and competitive systems of chemotaxis. The monograph concludes with the method of the weak scaling limit applied to the Smoluchowski‒Poisson equation.

The Mathematics Of Diffusion

Author: John Crank
Publisher: Oxford University Press
ISBN: 9780198534112
Size: 16.72 MB
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Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.

Mathematical Biology

Author: James D. Murray
Publisher: Springer Science & Business Media
ISBN: 3662085429
Size: 79.47 MB
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Mathematics has always benefited from its involvement with developing sciences. Each successive interaction revitalises and enhances the field. Biomedical science is clearly the premier science of the foreseeable future. For the continuing health of their subject mathematicians must become involved with biology. With the example of how mathematics has benefited from and influenced physics, it is clear that if mathematicians do not become involved in the biosciences they will simply not be a part of what are likely to be the most important and exciting scientific discoveries of all time. Mathematical biology is a fast growing, well recognised, albeit not clearly defined, subject and is, to my mind, the most exciting modern application of mathematics. The increasing use of mathematics in biology is inevitable as biol ogy becomes more quantitative. The complexity of the biological sciences makes interdisciplinary involvement essential. For the mathematician, biology opens up new and exciting branches while for the biologist mathematical modelling offers another research tool commmensurate with a new powerful laboratory technique but only if used appropriately and its limitations recognised. However, the use of esoteric mathematics arrogantly applied to biological problems by mathemati cians who know little about the real biology, together with unsubstantiated claims as to how important such theories are, does little to promote the interdisciplinary involvement which is so essential. Mathematical biology research, to be useful and interesting, must be relevant biologically.

Mathematical Modeling In Systems Biology

Author: Brian P. Ingalls
Publisher: MIT Press
ISBN: 0262315645
Size: 38.82 MB
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Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels.The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3--8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

The Porous Medium Equation

Author: Juan Luis Vazquez
Publisher: Oxford University Press
ISBN: 0198569033
Size: 77.45 MB
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Aimed at research students and academics in mathematics and engineering, as well as engineering specialists, this book provides a systematic and comprehensive presentation of the mathematical theory of the nonlinear heat equation usually called the Porous Medium Equation.

Mathematical Models In Biology

Author: Leah Edelstein-Keshet
Publisher: SIAM
ISBN: 9780898719147
Size: 21.44 MB
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Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in this book are still important and informative. Audience: the book does not assume too much background knowledge--essentially some calculus and high-school algebra. It was originally written with third- and fourth-year undergraduate mathematical-biology majors in mind; however, it was picked up by beginning graduate students as well as researchers in math (and some in biology) who wanted to learn about this field.

Mathematical Models And Their Analysis

Author: Frederick Y. M. Wan
Publisher: SIAM
ISBN: 1611975263
Size: 48.63 MB
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A great deal can be learned through modeling and mathematical analysis about real-life phenomena, even before numerical simulations are used to accurately portray the specific configuration of a situation. Scientific computing also becomes more effective and efficient if it is preceded by some preliminary analysis. These important advantages of mathematical modeling are demonstrated by models of historical importance in an easily understandable way. The organization of Mathematical Models and Their Analysis groups models by the issues that need to be addressed about the phenomena. The new approach shows how mathematics effective for one modeled phenomenon can be used to analyze another unrelated problem. For instance, the mathematics of differential equations useful in understanding the classical physics of planetary models, fluid motion, and heat conduction is also applicable to the seemingly unrelated phenomena of traffic flow and congestion, offshore sovereignty, and regulation of overfishing and deforestation. The formulation and in-depth analysis of these and other models on modern social issues, such as the management of exhaustible and renewable resources in response to consumption demands and economic growth, are of increasing concern to students and researchers of our time. The modeling of current social issues typically starts with a simple but meaningful model that may not capture all the important elements of the phenomenon. Predictions extracted from such a model may be informative but not compatible with all known observations; so the model may require improvements. The cycle of model formulation, analysis, interpretation, and assessment is made explicit for the modeler to repeat until a model is validated by consistency with all known facts.

Nonlocal Diffusion Problems

Author: Fuensanta Andreu-Vaillo
Publisher: American Mathematical Soc.
ISBN: 0821852302
Size: 37.67 MB
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Nonlocal diffusion problems arise in a wide variety of applications, including biology, image processing, particle systems, coagulation models, and mathematical finance. These types of problems are also of great interest for their purely mathematical content. This book presents recent results on nonlocal evolution equations with different boundary conditions, starting with the linear theory and moving to nonlinear cases, including two nonlocal models for the evolution of sandpiles. Both existence and uniqueness of solutions are considered, as well as their asymptotic behaviour. Moreover, the authors present results concerning limits of solutions of the nonlocal equations as a rescaling parameter tends to zero. With these limit procedures the most frequently used diffusion models are recovered: the heat equation, the $p$-Laplacian evolution equation, the porous media equation, the total variation flow, a convection-diffusion equation and the local models for the evolution of sandpiles due to Aronsson-Evans-Wu and Prigozhin. Readers are assumed to be familiar with the basic concepts and techniques of functional analysis and partial differential equations. The text is otherwise self-contained, with the exposition emphasizing an intuitive understanding and results given with full proofs. It is suitable for graduate students or researchers. The authors cover a subject that has received a great deal of attention in recent years. The book is intended as a reference tool for a general audience in analysis and PDEs, including mathematicians, engineers, physicists, biologists, and others interested in nonlocal diffusion problems.