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Permeability Of Biological Membranes

Author: Gaspar Banfalvi
Publisher: Springer
ISBN: 3319280988
Size: 63.78 MB
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This book deals with biological membranes, focuses on permeabilization and pays particular attention to reversible permeabilization to maintain the viability and physiological conditions of the cells. Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins. The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation. The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.

Membrane Permeability 100 Years Since Ernest Overton

Author:
Publisher: Academic Press
ISBN: 9780080585192
Size: 48.79 MB
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Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia. This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations. Provides an historical perspective of Overton's contributions to the theory of narcosis Presents an overview of each permeability mechanism, including active transport, endocytosis, exocytosis, and passive diffusion

Transport Across Single Biological Membranes

Author: D.C. Tosteson
Publisher: Springer Science & Business Media
ISBN: 3642463754
Size: 73.95 MB
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This second Volume in the series on Membrane Transport in Biology contains a group of essays on transport across single biological membranes separating the inside and outside of cells or organelles. We have not attempted to include material on all types of plasma and intracellular membranes, but rather have emphasized structures which have been studied relatively thoroughly. Four chapters describe transport of different types of molecules and ions across the plasma membranes of mammalian red cells. Two essays concern the excitable membranes of nerve and muscle cells while the remaining four chapters treat transport across several types of intracellular membranes. Water makes up more than two-thirds of the mass of most living cells. The transport of water between the inside and outside of cells and organelles is important for the function of these structures. As a result of investigations in many laboratories over the past four decades, our picture of the water permea bility of the red cell membranes is rather detailed when compared to the water permeability of other biological membranes. In Chapter 1, R. I. Macey describes this picture and also considers the permeability of red cell membranes to non electrolytes, including metabolic substrates such as sugars, amino acids, purines and nucleosides.

Biological Membranes

Author: Ove Sten-Knudsen
Publisher: Cambridge University Press
ISBN: 9780521810180
Size: 36.40 MB
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A comprehensive discussion of biological mass transfer and bioelectrical phenomena, written by a leading authority in the field.

The Structure Of Biological Membranes Third Edition

Author: Philip L. Yeagle
Publisher: CRC Press
ISBN: 1439809577
Size: 71.86 MB
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Biological membranes provide the fundamental structure of cells and viruses. Because much of what happens in a cell or in a virus occurs on, in, or across biological membranes, the study of membranes has rapidly permeated the fields of biology, pharmaceutical chemistry, and materials science. The Structure of Biological Membranes, Third Edition provides readers with an understanding of membrane structure and function that is rooted in the history of the field and brought to the forefront of current knowledge. The first part of the book focuses on the fundamentals of lipid bilayers and membrane proteins. Three introductory chapters supply those new to the field with the tools and conceptual framework with which to approach the state-of-the-art chapters that follow. The second part of the book presents in-depth analyses of focused subjects within the study of membranes, covering topics that include: Phase behavior of lipid bilayers Lipid bilayers as an isolated structure Cholesterol’s role in cell biology Lateral organization of membranes The role of membrane lipids in initial membrane protein folding Membrane protein synthesis and assembly of oligomeric membrane proteins Membrane protein stability with relationships to function and protein turnover Membrane protein function using a transport protein Interactions between membrane proteins and membrane lipids A final chapter pulls together many of the topics, examining in detail the complexity inherent in the synthesis and assembly of lipids and proteins in mitochondrial membranes. With contributions from leading researchers, this completely revised and updated third edition reflects recent advances in the field of biological membranes. It offers a valuable resource for students, as well as structural biologists, biophysicists, cell biologists, biochemists, and researchers in the pharmaceutical and biotechnology industries. What’s New in This Edition: Three accessible chapters introduce students to the field of biological membranes Completely revised and updated chapters present current topics in membrane research

Cellular Aspects Of Membrane Permeability

Author: E. Schoffeniels
Publisher: Elsevier
ISBN: 1483149102
Size: 46.45 MB
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Cellular Aspects of Membrane Permeability describes the state of knowledge on permeability problems and interprets experimental results within the framework of working hypotheses. The book discusses membrane permeability with some biochemical perspective presented to explain the origin and adaptations of animal life. The text explains the process and the driving forces affecting the permeability characteristics of the experimental object. It then discusses the distribution of ions and molecules between two phases separated by a living membrane. Then the text analyzes the chemical nature of the molecular architecture that causes such permeability characteristics. The book addresses the electrical potential profiles of epithelial tissues, and then discusses the conducting membranes. It also explains the relationships between inorganic ions, sugar, amino acids, fatty acids, and bioelectric potentials. The book also explains the physical nature of such chemical nature and structure of living membranes. The text then describes the structure of the cellular surface and the structural organization of the cell. The selection can prove useful for biologists, microbiologists, zoologists, and students and professors of biology and its related disciplines.

An Introduction To Biological Membranes

Author: William Stillwell
Publisher: Newnes
ISBN: 0080931286
Size: 13.39 MB
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An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. Brings together different facets of membrane research in a universally understandable manner Emphasis on the historical development of the field Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport.